The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

scientific article published in May 1994

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233). is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0360-3016(94)90291-7
P698PubMed publication ID8195035

P50authorAdrian HarrisQ37374768
Adam PattersonQ38324051
Ian StratfordQ56529169
P2093author name stringN Robertson
J Carmichael
G E Adams
M A Stephens
S Houlbrook
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)369-372
P577publication date1994-05-01
P1433published inInternational Journal of Radiation Oncology Biology PhysicsQ2296252
P1476titleThe role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233)
P478volume29

Reverse relations

cites work (P2860)
Q41099312Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity
Q41078518Enzymology of bioreductive drug activation
Q42261948Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).
Q28383023Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents
Q36292457Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents
Q35718471Induction of NQO1 in cancer cells
Q39769351Maximizing bactericidal activity with combinations of bioreduced drugs
Q43797318Metabolism of tirapazamine by multiple reductases in the nucleus
Q40899249NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line
Q36431422Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
Q26752388Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions
Q28547408Systematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coli
Q26774750Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
Q34090988Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia

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