Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects.

scientific article published on 17 February 2016

Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C5MB00711A
P8608Fatcat IDrelease_gvmdvv63nrcyjamsaddo3kfdii
P698PubMed publication ID26883206

P50authorPär JonssonQ52001570
Thomas MoritzQ54656435
Anna WuolikainenQ59573033
P2093author name stringMiles Trupp
Henrik Antti
Peter M Andersen
Stefan L Marklund
Maria Ahnlund
Lars Forsgren
P2860cites workalpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic populationQ21136353
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase IIQ24312770
2-Aminoadipic acid is a biomarker for diabetes riskQ24617890
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisQ26863439
ADSSL1 mutation relevant to autosomal recessive adolescent onset distal myopathyQ28114784
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerationsQ28274011
Metabolite profiling of Alzheimer's disease cerebrospinal fluidQ28480903
The role of autophagy in neurodegenerative diseaseQ29614834
Exenatide and the treatment of patients with Parkinson's diseaseQ30540208
Mass spectrometry-based metabolomicsQ33254576
Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterolQ33769607
Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS.Q33869419
Polyol pathway and diabetic peripheral neuropathyQ34800429
Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson diseaseQ35040454
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathwayQ35754540
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handlingQ35886625
Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samplesQ36162272
Risk of dementia in diabetes mellitus: a systematic reviewQ36345254
Metabolomic analysis and signatures in motor neuron diseaseQ36908588
Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathwaysQ37188890
Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse modelQ37285915
Metabolomics: moving to the clinicQ37462435
Dysregulation of glucose metabolism is an early event in sporadic Parkinson's diseaseQ37671390
EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task forceQ37931374
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?Q37944428
Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS.Q37972903
Excitotoxicity: bridge to various triggers in neurodegenerative disordersQ38057521
Looking back into the future: 30 years of metabolomics at TNO.Q38102969
Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolomeQ38195470
Defective autophagy in Parkinson's disease: lessons from geneticsQ38225786
Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine MetabolismQ38832035
Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acidsQ38998941
Metabolism. Differential regulation of mTORC1 by leucine and glutamineQ39211265
Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron diseaseQ39241061
ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations.Q39661561
A clinical trial of creatine in ALS.Q40469445
Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinson's diseaseQ42548051
Decrease in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in cerebrospinal fluid during elderly aging and in patients with sporadic form of amyotrophic lateral sclerosisQ43091395
Impaired glucose tolerance in patients with amyotrophic lateral sclerosisQ43149662
Hypermetabolism in ALS: correlations with clinical and paraclinical parametersQ43688446
Family history of neurodegenerative and vascular diseases in ALS: a population-based studyQ43909051
Extraction and GC/MS analysis of the human blood plasma metabolomeQ46849028
Familial aggregation of Parkinson's disease in the Faroe Islands.Q48370351
Kynurenine pathway abnormalities in Parkinson's disease.Q48434372
3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis.Q50732857
Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics.Q51071299
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?Q56049682
Orthogonal projections to latent structures (O-PLS)Q56435041
Principal component analysisQ56763826
OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classificationQ58045925
Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALSQ58125385
High metabolic level in patients with familial amyotrophic lateral sclerosisQ58125394
Alteration of amino acids in cerebrospinal fluid from patients with Parkinson's disease and spinocerebellar degenerationQ69503377
Metabolite and peptide levels in plasma and CSF differentiating healthy controls from patients with newly diagnosed Parkinson's diseaseQ88076090
P433issue4
P921main subjectParkinson's diseaseQ11085
amyotrophic lateral sclerosisQ206901
P304page(s)1287-1298
P577publication date2016-02-17
P1433published inMolecular BioSystemsQ3319467
P1476titleMulti-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects
P478volume12

Reverse relations

cites work (P2860)
Q114783473A Set of Reliable Samples for the Study of Biomarkers for the Early Diagnosis of Parkinson's Disease
Q64269328A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS
Q92259889A comprehensive protocol for multiplatform metabolomics analysis in patient-derived skin fibroblasts
Q89922975A comprehensive serum lipidome profiling of amyotrophic lateral sclerosis
Q50045364A glimmer of light at the end of the tunnel?
Q98194013Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients
Q93164263An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
Q90691805Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson's Disease
Q41666702Biomarker Research in Parkinson's Disease Using Metabolite Profiling
Q51299341Biomarker discovery using dry-lab technologies and high-throughput screening.
Q64079969Biomarkers in Motor Neuron Disease: A State of the Art Review
Q96585609Blood Biomarkers and Prognosis of Amyotrophic Lateral Sclerosis
Q100532384Brain Branched-Chain Amino Acids in Maple Syrup Urine Disease: Implications for Neurological Disorders
Q101063032Brain energy metabolism and multiple sclerosis: progress and prospects
Q102335828Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
Q98297801Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson's Disease: review and meta-analysis
Q64788297Cerebrospinal fluid biomarker for Parkinson's disease: An overview
Q38719357Changes in kynurenine pathway metabolism in Parkinson patients with L-DOPA-induced dyskinesia.
Q61796431Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers
Q100409450Circulating Metabolites as Potential Biomarkers for Neurological Disorders-Metabolites in Neurological Disorders
Q50027150Current state of bioanalytical chromatography in clinical analysis.
Q38639708Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.
Q91811242Existing and Emerging Metabolomic Tools for ALS Research
Q39033841Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis
Q96683446Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
Q33799643Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
Q101117355LC-MS/MS Determination of Modified Nucleosides in The Urine of Parkinson's Disease and Parkinsonian Syndromes Patients
Q97523046Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
Q55237897Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43.
Q50066234Metabolic Dysregulation in Amyotrophic Lateral Sclerosis: Challenges and Opportunities.
Q94955915Metabolite Profiling Reveals Predictive Biomarkers and the Absence of β-Methyl Amino-L-Alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis
Q51288392Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype.
Q47211940Metabolite profiling of obese individuals before and after a one year weight loss program
Q60304733Metabolomic investigations in cerebrospinal fluid of Parkinson's disease
Q60949835Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS
Q92754789Metabolomics analysis of Camellia sinensis with respect to harvesting time
Q38616672Metabolomics for Plant Improvement: Status and Prospects
Q54969000Metabolomics of Hydrazine-Induced Hepatotoxicity in Rats for Discovering Potential Biomarkers.
Q87872586Metabolomics of Major Depressive Disorder and Bipolar Disorder: Overview and Future Perspective
Q50090010Metabolomics toward personalized medicine.
Q41515229Multivariate strategy for the sample selection and integration of multi-batch data in metabolomics
Q90329666Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
Q61807813Polymorphisms of -, , and - Are Not Associated with Parkinson's Disease in Taiwan
Q93079386Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis
Q51761574Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease.
Q101561656Qualitative and Quantitative Analysis of Regional Cerebral Free Fatty Acids in Rats Using the Stable Isotope Labeling Liquid Chromatography-Mass Spectrometry Method
Q48043375Serum amino acid profile in patients with Parkinson's disease
Q96618576Serum creatinine levels in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis
Q98730855Shared perturbations in the metallome and metabolome of Alzheimer's, Parkinson's, Huntington's, and dementia with Lewy bodies: a systematic review
Q91265039Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS
Q60957114The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology
Q112107322The Metabolomic Approach Reveals the Alteration in Human Serum and Cerebrospinal Fluid Composition in Parkinson's Disease Patients
Q88500156Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels
Q99417290Untargeted metabolomics yields insight into ALS disease mechanisms
Q100387918Why TDP-43? Why Not? Mechanisms of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis
Q48851536Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling.

Search more.