Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment.

scientific article published in July 2017

Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment. is …
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scholarly articleQ13442814

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P356DOI10.1089/ADT.2017.797
P932PMC publication ID5549836
P698PubMed publication ID28723268

P50authorRanor BasaQ59700332
P2093author name stringJeffrey H Price
Patrick M McDonough
Natalie L Prigozhina
P2860cites workEstrogen Receptor β-Selective Agonists Stimulate Calcium Oscillations in Human and Mouse Embryonic Stem Cell-Derived NeuronsQ21562188
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cellsQ24314404
Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapsesQ24619549
Postmenopausal hormone therapy and cognitionQ27008086
Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell linesQ28384177
Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spinesQ28476085
G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neuronsQ28509959
Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release.Q31965193
GPR30 mediates estrogen rapid signaling and neuroprotectionQ33606426
Estrogen: a master regulator of bioenergetic systems in the brain and bodyQ33623924
Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alphaQ33715453
Hippocampal synaptic plasticity and cognitionQ33727832
Low-doses of cisplatin injure hippocampal synapses: a mechanism for 'chemo' brain?Q33763140
Changes in brain size during the menstrual cycleQ33822091
Prevalence, mechanisms, and management of cancer-related cognitive impairmentQ33854977
Quantification of lipid droplets and associated proteins in cellular models of obesity via high-content/high-throughput microscopy and automated image analysis.Q33860061
Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trialQ34065038
Dietary supplementation of soy germ phytoestrogens or estradiol improves spatial memory performance and increases gene expression of BDNF, TrkB receptor and synaptic factors in ovariectomized ratsQ34174689
Neurogenesis in the embryonic and adult brain: same regulators, different rolesQ34579598
Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysisQ34584283
Cognitive function in postmenopausal breast cancer patients one year after completing adjuvant endocrine therapy with letrozole and/or tamoxifen in the BIG 1-98 trialQ34604179
Quantification of hormone sensitive lipase phosphorylation and colocalization with lipid droplets in murine 3T3L1 and human subcutaneous adipocytes via automated digital microscopy and high-content analysis.Q35007906
Estradiol and cognitive function: past, present and futureQ35054370
Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons.Q35407526
Long-term consequences of estrogens administered in midlife on female cognitive agingQ35616166
High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive CompoundsQ35769756
Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activityQ35880083
Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18).Q35964527
CaMKII regulation in information processing and storageQ36287751
Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampusQ48340893
Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injuryQ48409977
Relationships between calcium and pH in the regulation of the slow afterhyperpolarization in cultured rat hippocampal neuronsQ48456224
Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neuronsQ48458332
Acute effect of beta amyloid on synchronized spontaneous Ca2+ oscillations in cultured hippocampal networksQ48487936
Axonal conduction slowing induced by spontaneous bursting activity in cortical neurons cultured in a microtunnel device.Q51008671
The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study.Q51975068
Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons.Q52538875
A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-d-aspartate receptors in cultured rat hippocampal neurons.Q52612453
Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormonesQ71388080
Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neuronsQ77789555
Ca2+ and synaptic plasticityQ81195228
Alteration of rat hippocampal neurogenesis and neuronal nitric oxide synthase expression upon prenatal exposure to tamoxifenQ84561215
Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutaseQ36372549
Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancerQ36420198
Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiolQ36618401
High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometryQ36886861
17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and FemalesQ36932944
Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia modelQ37113718
Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytesQ37227348
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.Q37245947
Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptorQ37255669
Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling.Q37436396
Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifenQ37595310
Neuro-cognitive impairment in breast cancer patients: pharmacological considerationsQ37947927
Position paper: The membrane estrogen receptor GPER--Clues and questionsQ38004279
Is basic research providing answers if adjuvant anti-estrogen treatment of breast cancer can induce cognitive impairment?Q38077049
PDE2 inhibition: potential for the treatment of cognitive disordersQ38159848
Hippocampal estradiol synthesis and its significance for hippocampal synaptic stability in male and female animalsQ38213325
Mitochondria: the gateway for tamoxifen-induced liver injury.Q38216454
Phosphodiesterase inhibition in cognitive declineQ38240108
Molecular signature of rapid estrogen regulation of synaptic connectivity and cognitionQ38243574
Expression of estrogen and progesterone receptors across human malignancies: new therapeutic opportunitiesQ38301592
Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms.Q38779220
Delineating the molecular mechanisms of tamoxifen's oncolytic actions in estrogen receptor-negative cancersQ38809446
Estrogen receptor beta interacts and colocalizes with HADHB in mitochondriaQ39273970
Cognitive effects of hormonal therapy in early stage breast cancer patients: a prospective studyQ40018051
NMDA receptor-dependent multidendrite Ca(2+) spikes required for hippocampal burst firing in vivoQ42454641
cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.Q42635596
The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experimentsQ43037201
Effects of tamoxifen on morphological and ultrastructural aspects of developing hippocampus of rat.Q43233988
Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein.Q43972766
Optical monitoring of excitatory synaptic activity between cultured hippocampal neurons by a multi-site Ca2+ fluorometryQ44249589
Cognitive effects of Tamoxifen in pre-menopausal women with breast cancer compared to healthy controlsQ44859258
Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatmentQ45481799
Signal propagation along unidimensional neuronal networksQ46622542
Activation of G-protein-coupled receptor 30 is sufficient to enhance spatial recognition memory in ovariectomized ratsQ47808389
Effects of tamoxifen, fluphenazine and estradiol on ATP levels in preoptic area and hypothalamic slices from ovariectomized ratsQ47836382
Cognitive functioning during long-term tamoxifen treatment in postmenopausal women with breast cancerQ47854376
Specific prediction of clinical QT prolongation by kinetic image cytometry in human stem cell derived cardiomyocytesQ47875731
Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipramQ48083856
Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spinesQ48278762
P433issue5
P921main subjectcognitive dysfunctionQ57859955
P304page(s)220-236
P577publication date2017-07-01
P1433published inAssay and Drug Development TechnologiesQ15767279
P1476titleAssay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment
P478volume15

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Q92247793High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neuronscites workP2860

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