Effect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial.

scientific article published on 12 July 2015

Effect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S2213-8587(15)00121-7
P698PubMed publication ID26179504

P2093author name stringA Rogier T Donders
Luc Noyez
Peter Pickkers
Gerard A Rongen
Niels P Riksen
Coert J Zuurbier
Rianne Nederlof
Hendrik-Jan Dieker
Marieke J Coenen
Saloua El Messaoudi
Henry A van Swieten
Annemieke Vos
P2860cites workInteraction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioningQ26995004
Use and abuse of HOMA modelingQ28263292
Coronary artery bypass grafting vs percutaneous coronary intervention and long-term mortality and morbidity in multivessel disease: meta-analysis of randomized clinical trials of the arterial grafting and stenting eraQ28303142
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) GroupQ29547282
Effect of remote ischemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trialsQ34349214
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore openingQ34725613
Metformin prevents myocardial reperfusion injury by activating the adenosine receptor.Q34964594
Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint studyQ35155185
The diabetic heart: too sweet for its own good?Q35810679
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery diseaseQ36782688
Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heartQ37686277
Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgeryQ37838146
The cardioprotective effects of metforminQ37928363
Cardioprotection: chances and challenges of its translation to the clinicQ38055280
Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trialQ38433159
Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon.Q42516922
Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion injury in humans.Q44261013
Recent metformin ingestion does not increase in-hospital morbidity or mortality after cardiac surgeryQ44599811
Ischemic postconditioning in pigs: no causal role for RISK activation.Q46225223
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signalingQ46847423
Chronic metformin treatment is associated with reduced myocardial infarct size in diabetic patients with ST-segment elevation myocardial infarctionQ47196867
Troponin T and B-type natriuretic peptide after on-pump cardiac surgery: prognostic impact on 12-month mortality and major cardiac events after adjustment for postoperative complications.Q47833302
Perioperative management of diabetic patients: new controversiesQ47835459
Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trialQ48572279
Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial.Q51325737
Protective effect of metformin on myocardial injury in metabolic syndrome patients following percutaneous coronary intervention.Q54390666
Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 geneQ57317083
Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependent K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro modelQ71730243
A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery diseaseQ73069750
Diabetes, metformin and lactic acidosisQ82255641
P433issue8
P921main subjectmetforminQ19484
coronary artery bypass surgeryQ186020
P304page(s)615-623
P577publication date2015-07-12
P1433published inThe Lancet: Diabetes & EndocrinologyQ27725107
P1476titleEffect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial.
P478volume3

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cites work (P2860)
Q36327207A randomized trial of remote ischemic preconditioning and control treatment for cardioprotection in sevoflurane-anesthetized CABG patients.
Q41498937A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction
Q48957301Biomimicking Platelet-Monocyte Interactions as a Novel Targeting Strategy for Heart Healing.
Q59813541Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients
Q37586444Harnessing the early post-injury inflammatory responses for cardiac regeneration
Q57180762Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology
Q43236315High Dose Meclizine Prevents Renal Ischemia-Reperfusion Injury in Healthy Male Mice
Q48273941In response to: Metformin for the management of peri-operative hyperglycaemia
Q58804510Liver enzyme trends in patients taking uninterrupted metformin before and after coronary surgery
Q37209499Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study
Q38338199Metformin improves the angiogenic potential of human CD34⁺ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction
Q85605784Metformin in cardiac surgery: high expectations
Q33743721Metformin is not associated with lactic acidosis in patients with diabetes undergoing coronary artery bypass graft surgery: a case control study
Q64092615New advances in perioperative cardioprotection
Q48302395Peri-operative continuation of metformin does not improve glycaemic control in patients with type 2 diabetes: A randomized controlled trial.
Q90703178Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study
Q38373147Two-year follow-up of 4 months metformin treatment vs. placebo in ST-elevation myocardial infarction: data from the GIPS-III RCT.

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