Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4.

scientific article published on 21 June 2007

Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2007.134387
P932PMC publication ID2277011
P698PubMed publication ID17584847
P5875ResearchGate publication ID6252227

P2093author name stringJames E Melvin
Carlos A Flores
Francisco V Sepúlveda
Carlos D Figueroa
P2860cites workA constitutively open potassium channel formed by KCNQ1 and KCNE3Q22011154
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Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colonQ28582188
Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in miceQ28585784
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-)Q28941777
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Electrolyte transport in the mammalian colon: mechanisms and implications for diseaseQ34482550
Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) miceQ34978226
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Cyclic AMP-dependent regulation of K+ transport in the rat distal colonQ35873805
Chloride conductance and genetic background modulate the cystic fibrosis phenotype of Delta F508 homozygous twins and siblingsQ36042699
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Distribution, properties, and functional characteristics of three classes of histamine receptorQ37885674
The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic cryptsQ38361060
Homocellular regulatory mechanisms in sodium-transporting epithelia: avoidance of extinction by "flush-through".Q40323328
Expression of intermediate conductance potassium channel immunoreactivity in neurons and epithelial cells of the rat gastrointestinal tract.Q40630949
Molecular and functional characterization of the small Ca(2+)-regulated K+ channel (rSK4) of colonic cryptsQ40923357
Immune regulation of human colonic electrolyte transport in vitro.Q42094659
A new class of inhibitors of cAMP-mediated Cl- secretion in rabbit colon, acting by the reduction of cAMP-activated K+ conductanceQ42480731
Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- currentQ42652553
Formal analysis of electrogenic sodium, potassium, chloride and bicarbonate transport in mouse colon epitheliumQ43188376
In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colonQ43792091
Activation of apical K+ conductances by muscarinic receptor stimulation in rat distal colon: fast and slow componentsQ44729180
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Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif.Q46697185
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Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.Q46984617
Characterization of apical potassium channels induced in rat distal colon during potassium adaptationQ47620982
Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E2 releaseQ48564083
Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.Q50787662
Evidence against direct activation of chloride secretion by carbachol in the rat distal colon.Q51610719
Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel.Q52572480
Localization of cAMP- and aldosterone-induced K+ secretion in rat distal colon by conductance scanning.Q52996219
Regional differences in rat large intestinal crypt function in relation to dehydrating capacity in vivo.Q54115082
Crypts are the site of intestinal fluid and electrolyte secretionQ56972270
Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitisQ58418813
Effects of histamine and histamine receptor antagonists on ion transport in rabbit descending colonQ72591943
Intestinal ion transport in NKCC1-deficient miceQ73003972
Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colonQ73257372
Cholinergic ion secretion in human colon requires coactivation by cAMPQ77649508
Role of cholinergic-activated KCa1.1 (BK), KCa3.1 (SK4) and KV7.1 (KCNQ1) channels in mouse colonic Cl- secretionQ79787474
Histamine-induced ion secretion across rat distal colon: involvement of histamine H1 and H2 receptorsQ80139724
Distal colonic K(+) secretion occurs via BK channelsQ83005232
Distinct K+ conductive pathways are required for Cl- and K+ secretion across distal colonic epitheliumQ83206026
P433issuePt 2
P407language of work or nameEnglishQ1860
P304page(s)705-717
P577publication date2007-06-21
P1433published inJournal of PhysiologyQ7743612
P1476titleAbolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4.
P478volume583

Reverse relations

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