Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic.

scientific article published on 5 December 2014

Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANIE.201409678
P698PubMed publication ID25483297

P50authorMaria Luisa GelmiQ57237393
Peta J HarveyQ57306980
Richard J. LewisQ40373224
Alessandro GoriQ41718756
P2093author name stringRenato Longhi
Andreas Brust
K Johan Rosengren
Paul F Alewood
Macdonald J Christie
Rebecca F Bhola
Ching-I A Wang
P2860cites workSolving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.Q43159292
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for painQ43254107
Engineering and functionalization of the disulfide-constrained miniprotein min-23 as a scaffold for diagnostic applicationQ45107054
Disulfide bonds, their stereospecific environment and conservation in protein structuresQ45171411
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channelsQ45805820
Maintaining biological activity by using triazoles as disulfide bond mimeticsQ46116432
Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogueQ46173962
Structure-activity relationship studies of gomesin: importance of the disulfide bridges for conformation, bioactivities, and serum stability.Q46762144
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonistsQ46962955
Cyclization of peptides by using selenolanthionine bridges.Q54210515
Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal painQ58284514
Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-DimethylsulfinylbenzhydrylQ58284530
Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine TransporterQ58284578
Conus venom peptide pharmacologyQ27003318
The Cyclic Cystine Ladder in  -Defensins Is Important for Structure and Stability, but Not Antibacterial ActivityQ27676502
Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stabilityQ27756877
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporterQ30991214
Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine proteaseQ33202737
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked painQ33287466
Cu-catalyzed azide-alkyne cycloadditionQ34807878
Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptidesQ36981618
Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulationQ37327551
Peptides and proteins as a continuing exciting source of inspiration for peptidomimeticsQ37900558
Venoms as a platform for human drugs: translating toxins into therapeuticsQ37937049
Cysteine-rich mini-proteins in human biology.Q38029087
Multifaceted roles of disulfide bonds. Peptides as therapeutics.Q38180456
Discovery, synthesis, and structure-activity relationships of conotoxins.Q38203598
Metabolism of neurohypophysial hormonesQ40846749
Oxidative folding of cystine-rich peptides vs regioselective cysteine pairing strategiesQ41094522
Disulfide-Depleted Selenoconopeptides: a Minimalist Strategy to Oxidative Folding of Cysteine-Rich PeptidesQ41853571
Serum Stabilities of Short Tryptophan- and Arginine-Rich Antimicrobial Peptide AnalogsQ41979383
Modulating oxytocin activity and plasma stability by disulfide bond engineeringQ42789969
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1361-1364
P577publication date2014-12-05
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleStabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic.
P478volume54