| scholarly article | Q13442814 |
| P2093 | author name string | John P Driver | |
| Clayton E Mathews | |||
| Yi-Guang Chen | |||
| P2860 | cites work | Compromised gut microbiota networks in children with anti-islet cell autoimmunity | Q46922105 |
| Autoreactive T cells in type 1 diabetes | Q48004838 | ||
| Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains | Q48070912 | ||
| Polygenic control of autoimmune diabetes in nonobese diabetic mice | Q48107213 | ||
| CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice | Q48340513 | ||
| Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice | Q50322131 | ||
| An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8. | Q51232583 | ||
| Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. | Q51369994 | ||
| Generation of gene-specific mutated rats using zinc-finger nucleases. | Q52597486 | ||
| Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex. | Q53859649 | ||
| Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. | Q53859655 | ||
| NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. | Q54034769 | ||
| The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. | Q54041415 | ||
| Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. | Q54139892 | ||
| Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. | Q54172602 | ||
| Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. | Q54468190 | ||
| Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. | Q55044269 | ||
| A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes | Q56897868 | ||
| Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes | Q56900944 | ||
| Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes | Q56902091 | ||
| Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1 | Q56902378 | ||
| Colocalization of Mouse Autoimmune Diabetes Loci Idd21.1 and Idd21.2 With IDDM6 (Human) and Iddm3 (Rat) | Q57155016 | ||
| Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction | Q57632624 | ||
| The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells | Q57632628 | ||
| Three Loci on Mouse Chromosome 6 Influence Onset and Final Incidence of Type I Diabetes in NOD.C3H Congenic Strains | Q57632635 | ||
| Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice | Q57782997 | ||
| Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain | Q59081148 | ||
| Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1 | Q60787779 | ||
| Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial | Q62587898 | ||
| Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene. | Q64891039 | ||
| A Molecular Basis for MHC Class II—Associated Autoimmunity | Q68355418 | ||
| Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4 | Q72492891 | ||
| Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice | Q73048923 | ||
| A mitochondrial genotype associated with the development of autoimmune-related type 1 diabetes | Q78432070 | ||
| Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development | Q79125427 | ||
| Association of the PTPN22/LYP gene with type 1 diabetes | Q79281980 | ||
| Enhanced early expansion and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese diabetic mice | Q79779585 | ||
| Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells | Q80731025 | ||
| Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onset | Q81040838 | ||
| HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes | Q82625833 | ||
| IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes | Q82676804 | ||
| The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells | Q83170079 | ||
| Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes | Q24632382 | ||
| Knockout rats via embryo microinjection of zinc-finger nucleases | Q24633888 | ||
| Gene targeting in the rat: advances and opportunities | Q24634563 | ||
| Innate immunity and intestinal microbiota in the development of Type 1 diabetes | Q24647312 | ||
| Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes | Q24652324 | ||
| The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings | Q27009048 | ||
| Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease | Q28201947 | ||
| Genome editing with engineered zinc finger nucleases | Q28290795 | ||
| Targeted integration in rat and mouse embryos with zinc-finger nucleases | Q28300670 | ||
| An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells | Q28610420 | ||
| A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference | Q29615920 | ||
| Type 1 diabetes mellitus | Q30235021 | ||
| Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers | Q30300404 | ||
| Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes | Q30416530 | ||
| Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs | Q30428049 | ||
| Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice | Q30453039 | ||
| Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping | Q31666533 | ||
| Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells | Q33556598 | ||
| Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. | Q33854444 | ||
| Early prediction of autoimmune (type 1) diabetes | Q33854613 | ||
| Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells. | Q33869811 | ||
| Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. | Q33918365 | ||
| Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice | Q33918370 | ||
| Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity | Q33918375 | ||
| Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. | Q34039427 | ||
| IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells | Q34096577 | ||
| Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes | Q37088185 | ||
| Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice | Q37089400 | ||
| Humanized mice for immune system investigation: progress, promise and challenges | Q37111994 | ||
| Gender bias in autoimmunity is influenced by microbiota. | Q37294725 | ||
| Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. | Q37300049 | ||
| Gene-gene interactions in the NOD mouse model of type 1 diabetes. | Q37359004 | ||
| Gene targeting in NOD mouse embryos using zinc-finger nucleases. | Q37403343 | ||
| Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus | Q37429069 | ||
| siRNA vs. shRNA: similarities and differences | Q37457195 | ||
| A humanized mouse model of autoimmune insulitis. | Q37715564 | ||
| Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease | Q37737987 | ||
| Zinc-finger nucleases: new strategies to target the rat genome | Q37771055 | ||
| Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation. | Q38576971 | ||
| Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes | Q38688772 | ||
| The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. | Q38874311 | ||
| A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. | Q38926045 | ||
| Haematopoietic stem and progenitor cells from human pluripotent stem cells. | Q40198119 | ||
| Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. | Q40257193 | ||
| Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes | Q40401659 | ||
| Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus | Q40581531 | ||
| Generation of stem cell-derived β-cells from patients with type 1 diabetes | Q41516470 | ||
| CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes | Q42019787 | ||
| The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells | Q42019839 | ||
| Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis | Q42211687 | ||
| Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1 | Q42620654 | ||
| Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci | Q43786589 | ||
| Effects of insulin in relatives of patients with type 1 diabetes mellitus | Q44010590 | ||
| Genetic analysis of autoimmune type 1 diabetes mellitus in mice | Q44110103 | ||
| Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. | Q44189001 | ||
| mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes | Q45251826 | ||
| Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes | Q45818945 | ||
| Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. | Q45929111 | ||
| Prevention of diabetes in NOD mice by a mutated I-Ab transgene. | Q46337520 | ||
| Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1. | Q46458859 | ||
| In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. | Q46583266 | ||
| PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes | Q46729790 | ||
| Evaluating preclinical efficacy | Q34208736 | ||
| A CRISPR view of development | Q34342877 | ||
| A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes | Q34421851 | ||
| Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes | Q34428346 | ||
| Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice | Q34479316 | ||
| The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique | Q34614636 | ||
| Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach | Q34718795 | ||
| A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. | Q34762243 | ||
| Testing agents for prevention or reversal of type 1 diabetes in rodents | Q34983677 | ||
| HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells | Q35043450 | ||
| The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function | Q35063250 | ||
| Long term effect of gut microbiota transfer on diabetes development | Q35157830 | ||
| Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes. | Q35242428 | ||
| The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes | Q35557877 | ||
| Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes | Q35603139 | ||
| Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes | Q35634096 | ||
| Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes | Q35661927 | ||
| Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs | Q35786213 | ||
| Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease | Q35821035 | ||
| Thinking bedside at the bench: the NOD mouse model of T1DM. | Q35911875 | ||
| Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes | Q35981325 | ||
| Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans | Q36004640 | ||
| Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice | Q36106586 | ||
| Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function | Q36182476 | ||
| Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes. | Q36186226 | ||
| Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes | Q36186271 | ||
| Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice | Q36255326 | ||
| Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes | Q36364041 | ||
| The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. | Q36421334 | ||
| Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement | Q36526326 | ||
| Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes. | Q36608775 | ||
| PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. | Q36635245 | ||
| Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes | Q36718178 | ||
| Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice | Q36975465 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | type-1 diabetes | Q124407 |
| P304 | page(s) | 51 | |
| P577 | publication date | 2018-02-23 | |
| P1433 | published in | Frontiers in Endocrinology | Q27723680 |
| P1476 | title | The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. | |
| P478 | volume | 9 |
| Q89724056 | A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes |
| Q92077777 | Bisphenol A alteration of type 1 diabetes in non-obese diabetic (NOD) female mice is dependent on window of exposure |
| Q61805076 | CD11c Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes |
| Q57172595 | Challenges to Reshape the Future of Type 1 Diabetes Research |
| Q64100285 | Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus |
| Q92685916 | Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes |
| Q98177245 | Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation |
| Q67994522 | Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset |
| Q60957167 | Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination |
| Q64072310 | Probiotics and Prebiotics for the Amelioration of Type 1 Diabetes: Present and Future Perspectives |
| Q91583997 | Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy |
| Q97643346 | UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice |
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