Poor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012-13.

scientific article published on 20 February 2018

Poor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012-13. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/CID/CIY097
P932PMC publication ID6051447
P698PubMed publication ID29471464

P50authorSarah CobeyQ56072288
Suman Ranjan DasQ86582854
Rebecca A HalpinQ87840921
Timothy B StockwellQ89222480
David E. WentworthQ37374449
P2093author name stringScott E Hensley
Xudong Lin
Yonatan H Grad
Benjamin A Pinsky
Kenneth E Schmader
Kaela Parkhouse
Hildegund C Ertl
Sigrid Gouma
Emily Landon
Ilan Youngster
Benjamin S Chambers
Vera Tesic
P2860cites workThe impact of influenza epidemics on mortality: introducing a severity index.Q54731473
MUSCLE: a multiple sequence alignment method with reduced time and space complexityQ21284290
Hemagglutinin receptor binding avidity drives influenza A virus antigenic driftQ24649073
Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza VirusesQ27312311
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed modelsQ27860746
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccinationQ28743596
Mortality associated with influenza and respiratory syncytial virus in the United StatesQ29615578
Immune history shapes specificity of pandemic H1N1 influenza antibody responses.Q30352126
Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humansQ30354893
Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses.Q30378960
Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans.Q30383252
Influenza immunization elicits antibodies specific for an egg-adapted vaccine strainQ30395005
Model estimates of the burden of outpatient visits attributable to influenza in the United StatesQ30395022
Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus StrainsQ30396097
Selectivity in mammalian extinction risk and threat types: a new measure of phylogenetic signal strength in binary traitsQ33534424
Recent H3N2 influenza virus clinical isolates rapidly acquire hemagglutinin or neuraminidase mutations when propagated for antigenic analysesQ34262280
Impact of repeated vaccination on vaccine effectiveness against influenza A(H3N2) and B during 8 seasonsQ34393525
Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studiesQ34451202
Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza seasonQ34480810
Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating virusesQ35130915
Influenza vaccine effectiveness in the United States during 2012-2013: variable protection by age and virus typeQ35531934
Disquisitions on Original Antigenic Sin. II. Proof in lower creaturesQ36268260
A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the agedQ36460789
The confounded effects of age and exposure history in response to influenza vaccinationQ36495901
B cell responses to the 2011/12-influenza vaccine in the agedQ36774876
Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccinationQ37635478
Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studiesQ38803189
Immune history and influenza virus susceptibilityQ39088963
Enhanced Genetic Characterization of Influenza A(H3N2) Viruses and Vaccine Effectiveness by Genetic Group, 2014-2015.Q40670577
Predetermination by infection and by vaccination of antibody response to influenza virus vaccinesQ41570161
A serologic recapitulation of past experiences with influenza A; antibody response to monovalent vaccineQ41831623
Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virusQ41874514
Substitutions near the receptor binding site determine major antigenic change during influenza virus evolutionQ42253862
Phandango: an interactive viewer for bacterial population genomics.Q42696231
Characterization of influenza antibodies by serum absorptionQ42822348
Influenza A virus molecular virology techniquesQ45358110
Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004-2005 season to the 2006-2007 seasonQ46159620
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.Q47150783
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectinfluenza vaccineQ383260
P577publication date2018-02-20
P1433published inClinical Infectious DiseasesQ5133764
P1476titlePoor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012-13.

Reverse relations

cites work (P2860)
Q100515758A chimeric influenza hemagglutinin delivered by parainfluenza virus 5 vector induces broadly protective immunity against genetically divergent influenza a H1 viruses in swine
Q90342429Association between the respiratory microbiome and susceptibility to influenza virus infection
Q98889330Comparison of immunogenicity between candidate influenza A(H3N2) virus vaccine strains in Japan: A randomized controlled trial using a monovalent vaccine of A/Saitama/103/2014 (CEXP-002) and A/Hong Kong/4801/2014 (X-263)
Q58722425Estimating Vaccine-Driven Selection in Seasonal Influenza
Q59349308Immune History and Influenza Vaccine Effectiveness
Q91842085Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals
Q98898240Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution
Q91941703Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets
Q57462323Response to Skowronski and De Serres
Q61796980Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype
Q57462327Role of Egg-adaptation Mutations in Low Influenza A(H3N2) Vaccine Effectiveness During the 2012-2013 Season
Q57094348The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine

Search more.