Conditional β1-integrin-deficient mice display impaired pancreatic β cell function.

scientific article published on 7 March 2011

Conditional β1-integrin-deficient mice display impaired pancreatic β cell function. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PATH.2849
P698PubMed publication ID21381031
P5875ResearchGate publication ID50291578

P2093author name stringJ Li
R Wang
S Liu
M Krishnamurthy
A Leask
M Riopel
P2860cites workIntegrins: bidirectional, allosteric signaling machinesQ27860700
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreasQ28587560
Functional consequences of integrin gene mutations in miceQ33182297
Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in miceQ34694998
Integrin regulation of cell signalling and motility.Q35780436
Mechanisms of integration of cells and extracellular matrices by integrins.Q35922901
Integrins: versatile integrators of extracellular signalsQ35963099
Clinging to life: cell to matrix adhesion and cell survivalQ36301231
Expression and function of alphabeta1 integrins in pancretic beta (INS-1) cellsQ39913741
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferationQ40308782
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetesQ40444628
Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathwayQ40530851
Alphav-integrin utilization in human beta-cell adhesion, spreading, and motilityQ40591735
Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrinQ40871552
Pancreas-specific ablation of beta1 integrin induces tissue degeneration by disrupting acinar cell polarityQ40980527
Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1.Q42469169
Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocystsQ42771254
Th1 and Th2 cytokines exert regulatory effects upon islet microvascular areas in the NOD mouseQ44124893
Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathwaysQ44995536
Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasisQ45161628
Expression of {beta}1 integrin receptors during rat pancreas development--sites and dynamicsQ45200776
beta1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival.Q45959395
Role for beta1 integrin and its associated alpha3, alpha5, and alpha6 subunits in development of the human fetal pancreasQ46570546
Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.Q47826102
c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice.Q51466529
The use of areas under curves in diabetes research.Q52352123
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.Q53591473
Differentiation of Embryonal Stem Cells into Keratinocytes: Comparison of Wild-Type and β1Integrin-Deficient CellsQ57385104
P433issue1
P304page(s)45-55
P577publication date2011-03-07
P1433published inJournal of PathologyQ400296
P1476titleConditional β1-integrin-deficient mice display impaired pancreatic β cell function.
P478volume224

Reverse relations

cites work (P2860)
Q37439142A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth
Q88662684Adhesion characteristics of porcine pancreatic islets and exocrine tissue to coating materials
Q36311562Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes
Q84119514Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model
Q41884593Critical role of β1 integrin in postnatal beta-cell function and expansion
Q36019448Diabetes imaging-quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy
Q50147080Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets.
Q48183469Fibrin supports human fetal islet-epithelial cell differentiation via p70(s6k) and promotes vascular formation during transplantation.
Q39757880Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling
Q26821954Human β-cell proliferation and intracellular signaling: part 3
Q36047564In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking
Q85561781Integrin β1 is required for dermal homeostasis
Q39308780Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
Q35987273Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions
Q33631551Myt3 Mediates Laminin-V/Integrin-β1-Induced Islet-Cell Migration via Tgfbi
Q35709830Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion
Q39165118Role and impact of the extracellular matrix on integrin-mediated pancreatic β-cell functions
Q47961247Signals in the pancreatic islet microenvironment influence β-cell proliferation.
Q30833091The biomechanical properties of an epithelial tissue determine the location of its vasculature
Q38569296The skeleton in the closet: actin cytoskeletal remodeling in β-cell function
Q37080791β1 integrin is a crucial regulator of pancreatic β-cell expansion
Q43792510β1 integrin-extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function
Q41207747β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

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