Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.

scientific article published on 3 August 2016

Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2016.08.003
P698PubMed publication ID27497529

P50authorAdrian TürkcanQ59682438
Bernhard ScharingerQ63844578
Hermann StuppnerQ88168368
Daniela SchusterQ37376677
Andreas RitschQ43055662
Herbert OberacherQ45409259
Barbara MessnerQ57662955
P2093author name stringAnna Vuorinen
Michael Grimm
Philipp Eller
David Bernhard
Günther Laufer
Florian Pitterl
Kathrin Arnhard
Katharina Heinz
P2860cites workThe Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart diseaseQ70309305
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New Lignan, Benzofuran, and Sesquiterpene Derivatives from the Roots of Leontopodium alpinum and L. leontopodioidesQ104955864
The Protein Data BankQ24515306
Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanismQ24603957
The LDL receptorQ24658039
Structural mechanism for statin inhibition of HMG-CoA reductaseQ27631717
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Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosisQ28209813
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive proteinQ29547752
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statinsQ29547856
Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural DatabaseQ30494222
Conformer generation with OMEGA: learning from the data set and the analysis of failuresQ30574063
LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filtersQ31143138
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitorsQ34207135
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Efficient overlay of small organic molecules using 3D pharmacophoresQ34575180
Clinical significance, pathogenesis, and management of postprandial hyperglycemiaQ35149496
Mouse models for atherosclerosis and pharmaceutical modifiers.Q36836487
Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.Q37193530
PPARγ signaling and metabolism: the good, the bad and the futureQ37407887
The diabetogenic action of statins - mechanisms and clinical implicationsQ38669513
Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer proteinQ39016597
Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levelsQ39624057
Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol loweringQ43516483
Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterolsQ43642121
Coronary atheroma volume and cardiovascular events during maximally intensive statin therapyQ47933695
P304page(s)35-46
P577publication date2016-08-03
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleLeoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice
P478volume99

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cites work (P2860)
Q93345028Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death
Q91784322Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease

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