A Phase I Clinical Trial of AZD1775 in Combination With Neoadjuvant Weekly Docetaxel and Cisplatin Before Definitive Therapy in Head and Neck Squamous Cell Carcinoma.

scientific article published on 13 March 2018

A Phase I Clinical Trial of AZD1775 in Combination With Neoadjuvant Weekly Docetaxel and Cisplatin Before Definitive Therapy in Head and Neck Squamous Cell Carcinoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-17-3796
P932PMC publication ID6004241
P698PubMed publication ID29535125

P50authorEric Q. KonnickQ51740671
Ahmed DiabQ61161465
R Alex HarbisonQ81891332
P2093author name stringLaura Q M Chow
Eduardo Méndez
Neal D Futran
Renato Martins
Rafael Santana-Davila
Sharat Raju
Cristina P Rodriguez
Ganesh M Mugundu
Michael C Kao
P2860cites workMK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cellsQ39442905
Applying Ancestry and Sex Computation as a Quality Control Tool in Targeted Next-Generation SequencingQ39813483
Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimensQ41906700
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracilQ43182482
Randomized phase III trial of neoadjuvant chemotherapy in head and neck cancer: 10-year follow-up.Q45152760
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Evaluation of dried blood spot (DBS) technology versus plasma analysis for the determination of MK-1775 by HILIC-MS/MS in support of clinical studiesQ46441349
Strategies for Targeted Therapy in Head and Neck Squamous Cell Carcinoma Using WEE1 Inhibitor AZD1775.Q50207725
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Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trialQ34328071
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancerQ34430205
Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescenceQ36020559
Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid TumorsQ36162494
Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic ProteinsQ36244669
Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1Q36956909
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonucleaseQ38256335
Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid TumorsQ38378490
Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapyQ39148462
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.Q39294122
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.Q39342402
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectdocetaxelQ420436
phase I clinical trialQ5452194
cisplatinQ412415
P304page(s)2740-2748
P577publication date2018-03-13
P1433published inClinical Cancer ResearchQ332253
P1476titleA Phase I Clinical Trial of AZD1775 in Combination With Neoadjuvant Weekly Docetaxel and Cisplatin Before Definitive Therapy in Head and Neck Squamous Cell Carcinoma.
P478volume24

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Q90710914Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy