scholarly article | Q13442814 |
P50 | author | Eric Q. Konnick | Q51740671 |
Ahmed Diab | Q61161465 | ||
R Alex Harbison | Q81891332 | ||
P2093 | author name string | Laura Q M Chow | |
Eduardo Méndez | |||
Neal D Futran | |||
Renato Martins | |||
Rafael Santana-Davila | |||
Sharat Raju | |||
Cristina P Rodriguez | |||
Ganesh M Mugundu | |||
Michael C Kao | |||
P2860 | cites work | MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells | Q39442905 |
Applying Ancestry and Sex Computation as a Quality Control Tool in Targeted Next-Generation Sequencing | Q39813483 | ||
Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens | Q41906700 | ||
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil | Q43182482 | ||
Randomized phase III trial of neoadjuvant chemotherapy in head and neck cancer: 10-year follow-up. | Q45152760 | ||
Microsatellite instability detection by next generation sequencing | Q45790131 | ||
Evaluation of dried blood spot (DBS) technology versus plasma analysis for the determination of MK-1775 by HILIC-MS/MS in support of clinical studies | Q46441349 | ||
Strategies for Targeted Therapy in Head and Neck Squamous Cell Carcinoma Using WEE1 Inhibitor AZD1775. | Q50207725 | ||
Cyclins A and E trigger DNA damage | Q60635068 | ||
Is there a new role for induction chemotherapy in the treatment of head and neck cancer? | Q81015149 | ||
ATM and ATR signaling at a glance | Q26777159 | ||
Comprehensive genomic characterization of head and neck squamous cell carcinomas | Q28256121 | ||
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 | Q29614651 | ||
The mutational landscape of head and neck squamous cell carcinoma | Q29614654 | ||
TP53 mutations and survival in squamous-cell carcinoma of the head and neck. | Q30366618 | ||
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. | Q30591228 | ||
Functional kinomics identifies candidate therapeutic targets in head and neck cancer | Q34055936 | ||
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial | Q34328071 | ||
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer | Q34430205 | ||
Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence | Q36020559 | ||
Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors | Q36162494 | ||
Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins | Q36244669 | ||
Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1 | Q36956909 | ||
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease | Q38256335 | ||
Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors | Q38378490 | ||
Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy | Q39148462 | ||
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. | Q39294122 | ||
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1. | Q39342402 | ||
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | docetaxel | Q420436 |
phase I clinical trial | Q5452194 | ||
cisplatin | Q412415 | ||
P304 | page(s) | 2740-2748 | |
P577 | publication date | 2018-03-13 | |
P1433 | published in | Clinical Cancer Research | Q332253 |
P1476 | title | A Phase I Clinical Trial of AZD1775 in Combination With Neoadjuvant Weekly Docetaxel and Cisplatin Before Definitive Therapy in Head and Neck Squamous Cell Carcinoma. | |
P478 | volume | 24 |
Q90975497 | Anti-Tumor Effects of Wee1 Kinase Inhibitor with Radiotherapy in Human Cervical Cancer |
Q89664714 | Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition |
Q91162952 | Personalized Cancer Models for Target Discovery and Precision Medicine |
Q90407471 | Phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: the WISTERIA trial protocol |
Q60046967 | Postoperative Combined Modality Treatment in High Risk Resected Locally Advanced Squamous Cell Carcinomas of the Head and Neck (HNSCC) |
Q92987297 | SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints |
Q89604649 | Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study |
Q89510155 | Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer |
Q57138889 | WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy |
Q90710914 | Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy |