Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study.

scientific article published in March 1999

Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0306-4522(98)00524-7
P698PubMed publication ID10218792

P50authorMiles HerkenhamQ47816901
P2093author name stringHohmann AG
P2860cites workThe analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic painQ28236298
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neuronsQ28245016
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyQ29615905
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.Q34554719
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin AQ34594580
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemQ34745063
Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nervesQ35874165
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cellsQ37599138
Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistryQ38331458
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.Q38340750
Neuropeptides in morphologically and functionally identified primary afferent neurons in dorsal root ganglia: substance P, CGRP and somatostatin.Q40940886
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.Q41292913
Effects of NMDA receptor blockade and nitric oxide synthase inhibition on the acute and chronic actions of delta 9-tetrahydrocannabinol in miceQ41664976
Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neuronsQ42450378
Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammationQ42474375
Localization of cannabinoid receptor mRNA in rat brainQ42510202
Alterations in myelinated fibres in the sciatic nerve of rats after constriction: possible relationships between the presence of abnormal small myelinated fibres and pain-related behaviourQ43479571
Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neuronsQ43741458
Optimization of cRNA probe in situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: a detailed protocol.Q44020270
Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root gangliaQ44333074
Expression of mu- and kappa-, but not delta-, opioid receptor mRNAs is enhanced in the spinal dorsal horn of the arthritic ratsQ44342268
Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatmentQ44350109
Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing studyQ45078410
Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species.Q46210588
Distribution of neurons expressing calcitonin gene-related peptide mRNAs in the brain stem, spinal cord and dorsal root ganglia of rat and guinea-pigQ46314115
The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic studyQ46333849
Antihyperalgesic effects of spinal cannabinoidsQ47625816
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptorsQ47626156
Glutamate-like immunoreactive structures in primary sensory neurons in the rat detected by a specific antiserum against glutamateQ48258041
Somatostatin mRNA: regional variation in hybridization densities in individual neuronsQ48285041
Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptideQ48375356
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slicesQ48726145
Semi-quantitative analysis of somatostatin mRNA distribution in the rat central nervous system using in situ hybridizationQ48789368
Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist: correlation between electrophysiological and antinociceptive effectsQ48890570
Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal culturesQ48963650
Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system.Q52070173
Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy.Q52481047
Distribution of somatostatin mRNA containing neurons in the primary pain relaying nuclei of the ratQ57855851
Fluoride-resistant acid phosphatase-containing neurones in dorsal root ganglia are separate from those containing substance P or somatostatinQ58493713
Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2Q60149864
Distribution of somatostatin mRNA in the rat nervous system as visualized by a novel non-radioactive in situ hybridization histochemistry procedureQ60684695
Co-expression of alpha-CGRP and beta-CGRP mRNAs in the rat dorsal root ganglion cellsQ68711048
Cell type and conduction velocity of rat primary sensory neurons with calcitonin gene-related peptide-like immunoreactivityQ68813314
Cell type and conduction velocity of rat primary sensory neurons with substance P-like immunoreactivityQ69062076
Abnormal discharge originates at the site of nerve injury in experimental constriction neuropathy (CCI) in the ratQ71474700
Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic painQ71658368
The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the ratQ71856943
A method for simultaneous detection of multiple mRNAs using digoxigenin and radioisotopic cRNA probesQ72620461
Suppression of noxious stimulus-evoked expression of Fos protein-like immunoreactivity in rat spinal cord by a selective cannabinoid agonistQ73337499
Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the ratQ74184497
Peptide plasticity in primary sensory neurons and spinal cord during adjuvant-induced arthritis in the rat: an immunocytochemical and in situ hybridization studyQ74184554
Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2Q77740584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcannabinoid receptorQ421237
cannabinoidsQ422936
CNR2Q17907844
P304page(s)923-931
P577publication date1999-03-01
P1433published inNeuroscienceQ15708571
P1476titleLocalization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study.
P478volume90

Reverse relations

cites work (P2860)
Q38370304A Review of Spasticity Treatments: Pharmacological and Interventional Approaches.
Q37067266A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain
Q44345700A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
Q44205907A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.
Q35843085A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons
Q34094132A role for the endogenous cannabinoid system in the peripheral control of pain initiation
Q37740479A systematic review of pharmacologic treatments of pain after spinal cord injury
Q34049519Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
Q43511723Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception
Q24683100Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS
Q45022904Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation
Q42625887Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis
Q44658192Activation of peripheral cannabinoid CB1 receptors inhibits mechanically evoked responses of spinal neurons in noninflamed rats and rats with hindpaw inflammation
Q42490287Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats
Q40818985Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons.
Q26824588Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases
Q31839936Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation.
Q38185073Anandamide in primary sensory neurons: too much of a good thing?
Q43901271Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin
Q35678770Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Q60690621Anandamide – the other side of the coin
Q33953174Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.
Q41038624Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists.
Q91959308Biological bases for a possible effect of cannabidiol in Parkinson's disease
Q57058269Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase synergize with the opioid analgesic morphine to suppress chemotherapy-induced neuropathic nociception without enhancing effects of morphine on gastrointestinal transit
Q28344830CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord
Q34098185CB2: a cannabinoid receptor with an identity crisis
Q42129148Cannabinoid 1 receptor knockout mice display cold allodynia, but enhanced recovery from spared-nerve injury-induced mechanical hypersensitivity.
Q39598750Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones.
Q39549838Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons.
Q33803774Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization
Q44551678Cannabinoid CB1 receptor inhibition of mechanically evoked responses of spinal neurones in control rats, but not in rats with hindpaw inflammation
Q35763485Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues by electroacupuncture.
Q43596412Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.
Q36978586Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation
Q34214210Cannabinoid modulation of peripheral autonomic and sensory neurotransmission
Q34921927Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function.
Q77740584Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2
Q28143655Cannabinoid receptors and pain
Q51982869Cannabinoid receptors undergo axonal flow in sensory nerves.
Q43543029Cannabinoidergic and opioidergic inhibition of spinal reflexes in the decerebrated, spinalized rabbit
Q39415164Cannabinoids and pain relief
Q34019573Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside
Q44209120Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats
Q34429295Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons
Q36447081Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Q36892931Cannabis and endocannabinoid modulators: Therapeutic promises and challenges
Q34786849Cardiovascular effects of cannabinoids
Q47804552Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly
Q90682483Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia
Q36990269Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons
Q34631608Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
Q37077524Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice
Q38707482Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Q44102435Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus.
Q36752224Dietary conditions and highly palatable food access alter rat cannabinoid receptor expression and binding density
Q41941144Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin
Q44344553Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons.
Q37284886Differential effects of the cannabinoid receptor agonist, WIN 55,212-2, on lamina I and lamina V spinal trigeminal nucleus caudalis neurons
Q44710513Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves
Q38593117Distribution of the Endocannabinoid System in the Central Nervous System
Q38211191Dronabinol and chronic pain: importance of mechanistic considerations
Q37495207Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy.
Q48186911Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors
Q34274062Endocannabinoid involvement in endometriosis.
Q38154691Endocannabinoid system and pain: an introduction
Q48639515Endocannabinoid-dependent plasticity at spinal nociceptor synapses
Q37363621Endocannabinoid-mediated control of synaptic transmission
Q34351200Endocannabinoids and exercise
Q34099017Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders
Q43540715Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis
Q37650292Examining the roles of cannabinoids in pain and other therapeutic indications: a review
Q43782827Functional changes in the inhibitory effect of spinal cannabinoid (CB) receptor activation in nerve injured rats
Q30385233G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.
Q89554788Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain
Q60731287Increased Cannabinoid Receptor 1-Immunoreactive Nerve Fibers in Overactive and Painful Bladder Disorders and Their Correlation With Symptoms
Q83973717Inhibition of 5-HT(3) receptors-activated currents by cannabinoids in rat trigeminal ganglion neurons
Q35035855Inhibition of pain responses by activation of CB(2) cannabinoid receptors
Q42034148Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms
Q44692991Intracerebroventricular but not intravenous interleukin-1beta induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation
Q35752224Involvement of cannabinoid receptors in gut motility and visceral perception
Q38185076Involvement of the endocannabinoid system in osteoarthritis pain
Q64212082Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry
Q28755529Localization of CB1 cannabinoid receptor mRNA in the brain of the chick (Gallus domesticus)
Q46074720Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.
Q34440671Mechanisms of exercise-induced hypoalgesia
Q28238995Mode of action of cannabinoids on nociceptive nerve endings
Q34247711Modulation of pain transmission by G-protein-coupled receptors
Q39650639Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites
Q37216017Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia.
Q35047032Multiple actions of anandamide on neonatal rat cultured sensory neurones
Q74571194Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord
Q34046213New perspectives on enigmatic vanilloid receptors.
Q47837489New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents
Q38287127Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain
Q33608432Peripheral gating of pain signals by endogenous lipid mediators
Q90451168Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats
Q41906880Physiological evidence of a postsynaptic inhibition of the tail flick reflex by a cannabinoid receptor agonist
Q98896096PnAn13, an antinociceptive synthetic peptide inspired in the Phoneutria nigriventer toxin PnTx4(6-1) (δ-Ctenitoxin-Pn1a)
Q34430635Possible mechanisms of cannabinoid-induced antinociception in the spinal cord
Q55002764Potential of Endocannabinoids to Control Bladder Pain.
Q44351566Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord
Q43948450Pre- and postsynaptic localizations of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cord.
Q42726526Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network.
Q39135834Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.
Q33527067Recent data on cannabinoids and their pharmacological implications in neuropathic pain
Q24794310Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
Q36726650Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes
Q44650597Selective Activation of Cannabinoid CB2 Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin
Q34206319Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
Q43814527Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo
Q53692390Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis.
Q37337607Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
Q36618089Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability
Q35600288Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain.
Q60916595Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55
Q37274198Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.
Q33897801Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system
Q35035850Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives
Q37529127Stress-induced sensitization of cortical adrenergic receptors following a history of cannabinoid exposure
Q33992517Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).
Q28271125TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat
Q37371095Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
Q89861376Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain
Q37382150Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation
Q37960078Targeting the endocannabinoid system for gastrointestinal diseases: future therapeutic strategies.
Q38600704The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.
Q38822341The Role of the Endocannabinoid System in the Brain-Gut Axis
Q30733453The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model
Q35029262The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat.
Q24676808The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
Q37182268The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms
Q35226232The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
Q84616297The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice
Q44031615The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats.
Q39697570The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats
Q34612917The endocannabinoid system and pain
Q33934278The endocannabinoid system as a target for therapeutic drugs.
Q28354238The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways
Q24522320The neurobiology and evolution of cannabinoid signalling
Q33720138The neurobiology of cannabinoid analgesia
Q35854891The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat.
Q37120771The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain
Q35921090The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
Q28362063The role of sensory nerve endings in nerve growth factor-induced airway hyperresponsiveness to histamine in guinea-pigs
Q36187065Therapeutic potential of cannabinoid receptor agonists as analgesic agents
Q45269970Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.
Q35915645Update on the role of cannabinoid receptors after ischemic stroke
Q74501955[The pharmacology of cannabinoid derivatives: are there applications to treatment of pain?]

Search more.