Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier.

scientific article published on 11 September 2015

Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3233/JAD-150469
P698PubMed publication ID26402114

P50authorLaurence FenartQ52148936
Fabien GosseletQ38801251
P2093author name stringMarie-Christine Boucau
Mélanie Kuntz
Emmanuel Sevin
Pietra Candela
Julien Saint-Pol
Yordenca Lamartinière
P2860cites workApolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer diseaseQ22248076
ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cellsQ24305511
Molecular interactions between apoE and ABCA1: impact on apoE lipidationQ24306797
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse modelsQ24628845
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer diseaseQ28261647
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's diseaseQ28294536
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based studyQ28366850
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".Q50963355
Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: implications for Alzheimer's disease.Q53317230
The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed DyslipidemiaQ57244233
A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cellsQ28539764
Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cellsQ28743314
Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"Q29013008
Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"Q29543792
Alzheimer's disease: the amyloid cascade hypothesisQ29547160
The blood-brain barrier in health and chronic neurodegenerative disordersQ29616411
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and functionQ30486577
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 miceQ30497102
Bexarotene reduces blood-brain barrier permeability in cerebral ischemia-reperfusion injured ratsQ30924126
Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades laterQ33621287
Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathwayQ33676328
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sitesQ33832954
Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's diseaseQ33862071
In vitro model for evaluating drug transport across the blood-brain barrierQ33904239
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse modelQ33915820
Modelling of the blood-brain barrier in drug discovery and development.Q34005458
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in miceQ34212267
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosisQ35601755
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's diseaseQ36229619
Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach.Q36789913
Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's diseaseQ36818632
Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement miceQ36822983
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 miceQ36958249
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegenerationQ37017266
Amyloid-β peptides, Alzheimer's disease and the blood-brain barrier.Q38155194
Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease.Q38166085
The emerging role of bexarotene in the treatment of Alzheimer's disease: current evidenceQ38364682
ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line.Q38918413
Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrierQ39297983
P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-betaQ39860990
Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrierQ40071369
Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generationQ40205410
24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expressionQ40209163
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysisQ40276692
Purification and ATPase activity of human ABCA1.Q40311731
Cholesterol modulates P-glycoprotein activity in human peripheral blood mononuclear cellsQ40576509
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse modelQ41844698
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's diseaseQ43286507
Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells.Q43465871
Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia.Q44208827
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brainQ44479225
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".Q45080391
DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 miceQ46171098
Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model.Q46256906
Accumulation of murine amyloid-β mimics early Alzheimer's disease.Q46726629
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.Q46738144
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer diseaseQ46738145
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 miceQ46738149
Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cellsQ46985780
Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.Q47767946
Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's diseaseQ47898570
Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterolQ48161830
Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.Q48823131
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cellsQ49036874
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectblood–brain barrierQ221694
P304page(s)849-862
P577publication date2015-09-11
P1433published inJournal of Alzheimer's DiseaseQ6294755
P1476titleBexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier.
P478volume48

Reverse relations

cites work (P2860)
Q91646694Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer's Disease and the Clinical Significance
Q94517987Axl receptor tyrosine kinase is a regulator of apolipoprotein E
Q88324973Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation
Q99238065Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders
Q92061776Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations
Q28071254Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases
Q39005365Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.
Q89550618Ketone Bodies Promote Amyloid-β1-40 Clearance in a Human in Vitro Blood-Brain Barrier Model
Q91803007PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux
Q47322495PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
Q37210123ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.
Q35950790Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines
Q38760636The pleiotropic vasoprotective functions of high density lipoproteins (HDL).
Q41862906β-Cyclodextrins Decrease Cholesterol Release and ABC-Associated Transporter Expression in Smooth Muscle Cells and Aortic Endothelial Cells

Search more.