Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63).

scientific article published in February 1998

Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2958.1998.00689.X
P698PubMed publication ID9489664
P5875ResearchGate publication ID13741347

P2093author name stringModi G
Sacks DL
McMaster WR
Joshi PB
P2860cites workPlasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiaeQ28265770
Molecular cloning of the major surface antigen of leishmaniaQ34175378
Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidaseQ34481004
Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycanQ35766941
The nucleotide sequence of leuA from Salmonella typhimurium.Q35832726
Deletion of an immunodominant Trypanosoma cruzi surface glycoprotein disrupts flagellum-cell adhesionQ36232637
Identification of Leishmania genes encoding proteins containing tandemly repeating peptidesQ36354280
Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycanQ36354656
Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan.Q36364463
Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expressionQ36721065
Double targeted gene replacement for creating null mutantsQ37578939
Nucleotide sequence of a plasmid born streptothricin-acetyl-transferase gene (sat-1).Q40453528
Mutational and functional analysis of the Leishmania surface metalloproteinase GP63: similarities to matrix metalloproteinasesQ40701933
Modification of GP63 genes from diverse species of Leishmania for expression of recombinant protein at high levels in Escherichia coliQ41161332
Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicanaQ41491846
The major surface glycoprotein (GP63) is present in both life stages of LeishmaniaQ41752302
Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinaseQ42069351
The promastigote surface protease (gp63) of Leishmania is expressed but differentially processed and localized in the amastigote stageQ43985877
Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotesQ44082213
Identification of a surface metalloproteinase on 13 species of Leishmania isolated from humans, Crithidia fasciculata, and Herpetomonas samuelpessoaiQ44918539
Crithidia fasciculata contains a transcribed leishmanial surface proteinase (gp63) gene homologueQ48139130
Structurally distinct genes for the surface protease of Leishmania mexicana are developmentally regulatedQ48139144
Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut.Q52231087
Developmental modification of the lipophosphoglycan from Leishmania major promastigotes during metacyclogenesis.Q52240329
Released glycoconjugate of indigenous Leishmania major enhances survival of a foreign L. major in Phlebotomus papatasi.Q52450385
Leishmania major and L. donovani: effects on proteolytic enzymes of Phlebotomus papatasi (Diptera, Psychodidae).Q52465092
Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63.Q52546385
The gene encoding streptothricin acetyltransferase (sat) as a selectable marker for Leishmania expression vectors.Q54175146
Leishmania major HEXBP deletion mutants generated by double targeted gene replacement.Q54216121
Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure.Q54656629
Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribedQ56762906
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectLeishmania majorQ1950715
P304page(s)519-530
P577publication date1998-02-01
P1433published inMolecular MicrobiologyQ6895967
P1476titleTargeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63).
P478volume27

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cites work (P2860)
Q39996005A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression.
Q35433080A perspective on the emergence of sialic acids as potent determinants affecting leishmania biology
Q35188674Animal models for the analysis of immune responses to leishmaniasis
Q33279371Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro
Q35745876Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania
Q33397068Characterization of DNA sequences that confer complement resistance in Leishmania chagasi
Q39098197Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection
Q45374298Design of protease-resistant pexiganan enhances antileishmanial activity
Q45209464Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials
Q47815725Differential expression of GP63 genes in Trypanosoma cruzi
Q36778915Differential surface deposition of complement proteins on logarithmic and stationary phase Leishmania chagasi promastigotes.
Q34347500Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?
Q34543547Dressed for success: the surface coats of insect-borne protozoan parasites
Q34002959Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro
Q90317136Establishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening
Q48249997Expression and Function of the Trypanosoma brucei Major Surface Protease (GP63) Genes
Q43845834Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence
Q44552477Extracellular release of the surface metalloprotease, gp63, from Leishmania and insect trypanosomatids.
Q34282182Function and assembly of the Leishmania surface coat
Q43789213Functional glycosylphosphatidylinositol anchor signal sequences in the Pneumocystis carinii PRT1 protease family
Q52603674Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions.
Q43073222Gene regulation of pteridine reductase 1 in leishmania promastigotes and amastigotes using a full-length antisense construct
Q33231863Genetic complementation to identify DNA elements that influence complement resistance in Leishmania chagasi
Q39851491Genome-wide analysis reveals increased levels of transcripts related with infectivity in peanut lectin non-agglutinated promastigotes of Leishmania infantum.
Q33611111How do protozoan parasites survive inside macrophages?
Q34520491How to succeed in parasitic life without sex? Asking Leishmania
Q36915063Immune response regulation by leishmania secreted and nonsecreted antigens
Q27013029Impact of Leishmania metalloprotease GP63 on macrophage signaling
Q56449802In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors
Q36024566In vitro infectivity and differential gene expression of Leishmania infantum metacyclic promastigotes: negative selection with peanut agglutinin in culture versus isolation from the stomodeal valve of Phlebotomus perniciosus
Q53611497In vitro metacyclogenesis of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis clinical field isolates, as evaluated by morphology, complement resistance, and infectivity to human macrophages.
Q40529912Involvement of Leishmania donovani major surface glycoprotein gp63 in promastigote multiplication
Q34232557Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species
Q34181208Leishmania Subtilisin Is a Maturase for the Trypanothione Reductase System and Contributes to Disease Pathology
Q36499194Leishmania development in sand flies: parasite-vector interactions overview
Q36371532Leishmania major LACK antigen is required for efficient vertebrate parasitization
Q33750020Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern
Q34701006Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.
Q55002022Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus.
Q58779353Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation
Q42177826Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection
Q41825252Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein
Q33542293Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.
Q36511643Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review].
Q77361043Roles of free GPIs in amastigotes of Leishmania
Q33969495Secretory pathway of trypanosomatid parasites
Q48352877Stage-specific expression in Leishmania conferred by 3' untranslated regions of L. major leishmanolysin genes (GP63).
Q40049255Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis
Q33755221Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view.
Q37119803The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation
Q35623857The genetic toolbox for Leishmania parasites
Q35561779The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function.
Q34452594The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion
Q51049940The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies.
Q37081691Transgenic Leishmania and the immune response to infection
Q42002483gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani.

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