Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer.

scientific article published on 23 April 2018

Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10863-018-9755-Y
P698PubMed publication ID29687367

P2093author name stringYin He
Zhuo Lv
Chun Su
Liying Lu
Xintong Yan
P2860cites workSignaling Pathways in Thyroid Cancer and Their Therapeutic ImplicationsQ26764899
Mitochondrial Energy Metabolism and Thyroid CancersQ26801685
Targeting mitochondria metabolism for cancer therapyQ27027219
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug actionQ27690642
Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanismsQ33702514
Doxorubicin, DNA torsion, and chromatin dynamicsQ34039414
FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin ToxicityQ35832107
Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.Q36328030
Pathogenetic mechanisms in thyroid follicular-cell neoplasiaQ36430189
Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respirationQ36545282
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.Q37129502
Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cellsQ37376205
Function of mitochondrial Stat3 in cellular respirationQ37378567
Thyroid cancer epidemiology and prognostic variablesQ37772326
Molecular genetics and diagnosis of thyroid cancerQ37924088
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cellsQ38353138
The novel role of pyrvinium in cancer therapy.Q38684406
Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2/STAT5.Q38808854
Anaplastic Thyroid Carcinoma: Treatment in the Age of Molecular Targeted Therapy.Q38862005
Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complexQ38908333
Erk1/2 activation and modulation of STAT3 signaling in oral cancerQ38961376
Thyroid cancer cell lines: an overview.Q39242802
Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3.Q39419264
Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.Q39820685
Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasiteQ41929069
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agentQ42094834
Establishment of human cell lines lacking mitochondrial DNA.Q45975304
The role of mitochondrial dysfunction in cardiovascular disease: a brief review.Q46241976
Atovaquone suspension in HIV-infected volunteers: pharmacokinetics, pharmacodynamics, and TMP-SMX interaction study.Q51559180
Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)Q67487758
P577publication date2018-04-23
P1433published inJournal of Bioenergetics and BiomembranesQ5044470
P1476titleAtovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer.

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cites work (P2860)
Q91592473Atovaquone: An Antiprotozoal Drug Suppresses Primary and Resistant Breast Tumor Growth by Inhibiting HER2/β-Catenin Signaling
Q58723357Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer
Q90119326Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

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