Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus.

scientific article published on 5 April 2018

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FMICB.2018.00649
P932PMC publication ID5895659
P698PubMed publication ID29675007

P50authorLaurent KremerQ56861257
Eric GhigoQ67359363
Mickael BlaiseQ46953466
P2093author name stringMatthias Richard
Ana Victoria Gutiérrez
Albertus J Viljoen
P2860cites workPHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
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EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targetsQ28486213
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Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functionsQ35675954
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Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistenceQ36096266
Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.Q36251994
Structural basis for interaction between Mycobacterium smegmatis Ms6564, a TetR family master regulator, and its target DNA.Q37099672
A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonaeQ37144788
Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosisQ37334924
A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants.Q52690344
Elucidation of Mycobacterium abscessus aminoglycoside and capreomycin resistance by targeted deletion of three putative resistance genes.Q53740832
Multidrug-resistant Mycobacterium abscessus threatens patients with cystic fibrosis.Q53757952
Thermodynamic analysis of tetracycline-mediated induction of Tet repressor by a quantitative methylation protection assayQ71366134
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacteriumQ37481693
Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation.Q37640941
Mycobacterium abscessus: a new antibiotic nightmareQ37980031
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Mycobacterium abscessus Complex - a Particular Challenge in the Setting of Lung Transplantation.Q38687467
Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosisQ38849126
β-Lactamase inhibition by avibactam in Mycobacterium abscessusQ38927000
MmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteriaQ38935075
Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish EmbryosQ38962641
Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatmentQ38969052
Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591.Q39080590
The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.Q39199131
Mycobacterium abscessus WhiB7 regulates a species -specific repertoire of genes to confer extreme antibiotic resistanceQ40065956
Inhibition of the β-Lactamase BlaMab by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessusQ40368667
Mechanisms underlying expression of Tn10 encoded tetracycline resistanceQ40572946
MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus.Q40579776
Bactericidal and intracellular activity of β-lactams against Mycobacterium abscessus.Q40772367
LfrR is a repressor that regulates expression of the efflux pump LfrA in Mycobacterium smegmatisQ40903335
Site-directed mutagenesis using overlap extension PCR.Q41146173
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein.Q44468465
Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosisQ45114950
A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonaeQ45224934
Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux systemQ46319031
Molecular Mechanisms of Intrinsic Streptomycin Resistance in Mycobacterium abscessus.Q50072876
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectMycobacterium abscessusQ6946978
P304page(s)649
P577publication date2018-04-05
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleMechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus.
P478volume9

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cites work (P2860)
Q64103237Draft Genome Sequences of 12 Strains Resistant to Imidazo[1,2-][1,2,4,5]Tetrazines
Q92001476Genetic Evolution of Mycobacterium abscessus Conferring Clarithromycin Resistance during Long-Term Antibiotic Therapy
Q89976320MmpS5-MmpL5 Transporters Provide Mycobacterium smegmatis Resistance to imidazo[1,2-b][1,2,4,5]tetrazines
Q57461259Mutations in the MAB_2299c TetR regulator confer cross-resistance to clofazimine and bedaquiline in
Q57832878Mutations in the MAB_2299c TetR regulator confer cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus
Q89838336Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus
Q92091413The TetR Family Transcription Factor MAB_2299c Regulates the Expression of Two Distinct MmpS-MmpL Efflux Pumps Involved in Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus

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