Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection

scientific article published on 2 April 2018

Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1101895204
P356DOI10.1186/S12977-018-0410-9
P932PMC publication ID5879932
P698PubMed publication ID29609648

P2093author name stringHongyun Wang
Rui Zhang
Yasushi Kawaguchi
Zene Matsuda
Qingling Du
Jun-Ichiro Inoue
Mizuki Yamamoto
Dehua Liu
Jiping Song
P2860cites workHIV: cell binding and entryQ27008983
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Structural and functional analysis of interhelical interactions in the human immunodeficiency virus type 1 gp41 envelope glycoprotein by alanine-scanning mutagenesisQ27635422
Site-specific Mutations in HIV-1 gp41 Reveal a Correlation between HIV-1-mediated Bystander Apoptosis and Fusion/HemifusionQ57372687
Cell-Surface-Expressed HIV-1 Envelope Induces the Death of CD4 T Cells during GP41-Mediated Hemifusion-like EventsQ61656818
Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodiesQ72146275
Core structure of gp41 from the HIV envelope glycoproteinQ27736064
Atomic structure of the ectodomain from HIV-1 gp41Q27738021
Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusionQ28646673
HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion processQ28646687
Mechanisms of viral membrane fusion and its inhibitionQ29616090
Conformational changes of the HIV-1 envelope protein during membrane fusion are inhibited by the replacement of its membrane-spanning domain.Q30494327
Role of the specific amino acid sequence of the membrane-spanning domain of human immunodeficiency virus type 1 in membrane fusionQ33724164
Role of the membrane-proximal domain in the initial stages of human immunodeficiency virus type 1 envelope glycoprotein-mediated membrane fusion.Q33815984
Time-resolved imaging of HIV-1 Env-mediated lipid and content mixing between a single virion and cell membraneQ34148120
HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formationQ34812952
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Q35142291
Co-expression of foreign proteins tethered to HIV-1 envelope glycoprotein on the cell surface by introducing an intervening second membrane-spanning domainQ35164416
The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargementQ35887194
Significant differences in cell-cell fusion and viral entry between strains revealed by scanning mutagenesis of the C-heptad repeat of HIV gp41Q36390483
Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric InteractionsQ37065151
Dual split protein-based fusion assay reveals that mutations to herpes simplex virus (HSV) glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteinsQ37252695
Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides.Q37831811
Insights into the trimeric HIV-1 envelope glycoprotein structureQ38323609
Recent advance in the structural analysis of HIV-1 envelope proteinQ38447922
Dual Split Protein (DSP) Assay to Monitor Cell-Cell Membrane FusionQ38878408
Development of a rapid cell-fusion-based phenotypic HIV-1 tropism assayQ39094162
Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozymeQ39114490
Generation of a dual-functional split-reporter protein for monitoring membrane fusion using self-associating split GFP.Q39286453
Conserved arginine residue in the membrane-spanning domain of HIV-1 gp41 is required for efficient membrane fusionQ39525705
Alanine scanning mutagenesis of HIV-1 gp41 heptad repeat 1: insight into the gp120-gp41 interactionQ39702781
The six-helix bundle of human immunodeficiency virus Env controls pore formation and enlargement and is initiated at residues proximal to the hairpin turnQ39822146
Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimerQ39949085
Alanine scanning mutants of the HIV gp41 loopQ40419657
Role of the ectodomain of the gp41 transmembrane envelope protein of human immunodeficiency virus type 1 in late steps of the membrane fusion processQ40604377
The V4 and V5 Variable Loops of HIV-1 Envelope Glycoprotein Are Tolerant to Insertion of Green Fluorescent Protein and Are Useful Targets for LabelingQ41287677
Enveloped viruses: A common mode of membrane fusion?Q41585925
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)27
P577publication date2018-04-02
P1433published inRetrovirologyQ15793508
P1476titleSix-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection
P478volume15

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