Over-expression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx/Wzy-dependent pathway enhances production of defined modal length O polysaccharide polymers for use as haptens in glycoconjugate vaccines.

scientific article published on 30 March 2018

Over-expression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx/Wzy-dependent pathway enhances production of defined modal length O polysaccharide polymers for use as haptens in glycoconjugate vaccines. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JAM.13772
P932PMC publication ID6726474
P698PubMed publication ID29603538

P2093author name stringG Ramachandran
J E Galen
M M Levine
R Simon
N Hegerle
J Bose
S M Tennant
P2860cites workKlebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factorsQ24550738
O-antigen modal chain length in Shigella flexneri 2a is growth-regulated through RfaH-mediated transcriptional control of the wzy geneQ94604168
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Pseudomonas aeruginosa O-antigen chain length is determined before ligation to lipid A coreQ28492709
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Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidisQ35272921
Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strainsQ35273267
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Artificial Salmonella Vaccines: Salmonella typhimurium O-Antigen-Specific Oligosaccharide-Protein Conjugates Elicit Protective Antibodies in Rabbits and MiceQ36446367
lfnA from Pseudomonas aeruginosa O12 and wbuX from Escherichia coli O145 encode membrane-associated proteins and are required for expression of 2,6-dideoxy-2-acetamidino-L-galactose in lipopolysaccharide O antigen.Q36483217
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Evaluation of commercially available antisera for serotyping of Pseudomonas aeruginosaQ41236319
The cellular level of O-antigen polymerase Wzy determines chain length regulation by WzzB and WzzpHS-2 in Shigella flexneri 2a.Q42277297
A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infectionQ43461979
Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella.Q50060625
Regulation of Salmonella typhimurium lipopolysaccharide O antigen chain length is required for virulence; identification of FepE as a second Wzz.Q50105059
Impact of conjugation chemistry on the immunogenicity of S. Typhimurium conjugate vaccinesQ50425114
Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults.Q54572055
Immunogenicity of a 24-valent Klebsiella capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide conjugate vaccine administered to victims of acute traumaQ71554787
Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseasesQ80986374
Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free mediaQ81445405
P433issue2
P921main subjectpolysaccharideQ134219
P304page(s)575-585
P577publication date2018-05-15
P1433published inJournal of Applied MicrobiologyQ15756992
P1476titleOverexpression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx-/Wzy-dependent pathway enhances production of defined modal length O-polysaccharide polymers for use as haptens in glycoconjugate vaccines
P478volume125

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cites work (P2860)
Q92487093Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human
Q64095474Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to
Q90290863Maternal Antibodies Elicited by Immunization With an O- Polysaccharide Glycoconjugate Vaccine Protect Infant Mice Against Lethal Salmonella Typhimurium Infection
Q92170137Unique Regions of the Polysaccharide Copolymerase Wzz2 from Pseudomonas aeruginosa Are Essential for O-Specific Antigen Chain Length Control

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