Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models.

scientific article published on 15 March 2018

Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00424-018-2123-2
P932PMC publication ID6060757
P698PubMed publication ID29541860

P50authorDenis Vecellio ReaneQ64358426
Cristina MammucariQ64684658
P2093author name stringAnna Raffaello
Rosario Rizzuto
Gaia Gherardi
Agnese De Mario
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Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).Q42595152
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Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses.Q44066992
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Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transitionQ48061561
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Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformationQ48348421
Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family.Q49041959
Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.Q49326217
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+Q50127791
A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca2+ Uptake Machinery of Skeletal Muscle.Q50860658
Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria.Q52323118
A third contribution regarding the Influence of the Inorganic Constituents of the Blood on the Ventricular ContractionQ58718423
Mitochondrial Nitric-oxide Synthase Stimulation Causes CytochromecRelease from Isolated MitochondriaQ60532716
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Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cationsQ67749578
Calcium uptake and membrane potential in mitochondriaQ68827771
Ca2+ stimulation of rat liver mitochondrial glycerophosphate dehydrogenaseQ71578482
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptakeQ24294670
The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretionQ24300697
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survivalQ24301822
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolismQ24304898
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporterQ24306825
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterQ24306850
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptakeQ24336668
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activityQ24338031
EMRE is an essential component of the mitochondrial calcium uniporter complexQ24339589
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The regulation of neuronal mitochondrial metabolism by calciumQ26823765
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegenerationQ27310252
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporterQ27938400
Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and RelaxationQ28073189
SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell deathQ28118248
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
Cardiac excitation-contraction couplingQ28216347
Dimers of mitochondrial ATP synthase form the permeability transition poreQ28287824
Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport.Q28362214
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handlingQ28486060
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunitQ28591017
CaMKII determines mitochondrial stress responses in heartQ28591986
Neuronal calcium signalingQ29614727
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanismQ29616055
The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viabilityQ30274561
Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structuresQ30485709
Reconstitution of the mitochondrial calcium uniporter in yeastQ33790020
Susceptibility to Calcium Dysregulation during Brain AgingQ33868432
Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondriaQ34147741
Calcium movement in cardiac mitochondriaQ34205072
Chemiosmotic coupling in oxidative and photosynthetic phosphorylationQ34231345
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosisQ34275661
Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basisQ34283666
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopyQ34307392
Unresolved questions from the analysis of mice lacking MCU expressionQ34425694
Mitochondrial function in normal and diabetic beta-cellsQ34462332
Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients?Q34478944
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machineryQ34802768
Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cellsQ35080264
The mitochondrial calcium uniporter controls skeletal muscle trophism in vivoQ35152163
Identification of genes that promote or inhibit olfactory memory formation in DrosophilaQ35342502
The mitochondrial uniporter controls fight or flight heart rate increases.Q35438927
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the HeartQ35836414
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.Q35895526
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Type 2 diabetes: principles of pathogenesis and therapyQ36095054
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Q36146320
Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytesQ36167513
In vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contractionQ36322181
Structure and function of the N-terminal domain of the human mitochondrial calcium uniporterQ36327478
Calcium uptake by rat kidney mitochondriaQ36441249
Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.Q36550699
Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.Q36592212
Ca2+ microdomains and the control of insulin secretionQ36618699
Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cellsQ36780471
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.Q36895350
Architecture of the mitochondrial calcium uniporterQ36922063
Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signalingQ37011991
Activity of the mitochondrial calcium uniporter varies greatly between tissuesQ37281674
NFAT isoforms control activity-dependent muscle fiber type specificationQ37304070
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.Q37366133
Subcellular analysis of Ca2+ homeostasis in primary cultures of skeletal muscle myotubesQ37384417
A CaPful of mechanisms regulating the mitochondrial permeability transitionQ37419777
Regulation of mitochondrial dehydrogenases by calcium ionsQ37469373
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporterQ37707538
Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthaseQ37737116
Fiber types in mammalian skeletal musclesQ37947567
Mitochondria as sensors and regulators of calcium signallingQ38031124
Neuronal calcium signaling: function and dysfunctionQ38179996
How does calcium regulate mitochondrial energetics in the heart? - new insightsQ38198401
Cellular mechanisms and physiological consequences of redox-dependent signallingQ38214052
Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injuryQ38244750
Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.Q38252722
Activity-driven local ATP synthesis is required for synaptic function.Q38281904
Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult DrosophilaQ38436297
Standing of giants shoulders the story of the mitochondrial Na(+)Ca(2+) exchangerQ38496543
Regulation of neurogenesis by calcium signalingQ38791474
A mitochondrial switch promotes tumor metastasis.Q38971261
Crosstalk between calcium and reactive oxygen species signaling in cancer.Q39112253
Calcium signaling and molecular mechanisms underlying neurodegenerative diseasesQ39152527
Local and regional control of calcium dynamics in the pancreatic isletQ39280087
Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cellsQ39294913
Calcium and regulation of the mitochondrial permeability transition.Q39316399
Calcium and Excitation-Contraction Coupling in the HeartQ39419376
Analysis of the structure and function of EMRE in a yeast expression systemQ39899817
Regulation of insulin release by calciumQ40085413
Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorinQ41112236
Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthaseQ41562382
Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter releaseQ41737185
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability TransitionQ41822328
EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.Q41889367
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporterQ41976396
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P921main subjectcalciumQ706
cellQ7868
inorganic compoundQ190065
P304page(s)1165-1179
P577publication date2018-03-15
2018-08-01
P1433published inPfluegers ArchivQ1091689
P1476titleMitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models
P478volume470

Reverse relations

cites work (P2860)
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