Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.

scientific article published in March 2018

Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2018.01.039
P932PMC publication ID5912153
P698PubMed publication ID29499137

P2093author name stringXin Yang
Xin Liu
Lianying Jiao
Siming Chen
Murtada Shubbar
P2860cites workMolecular architecture of human polycomb repressive complex 2Q21128799
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Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiationQ24304060
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An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targetingQ24307370
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumorsQ24626904
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Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by the Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) ComplexQ27644320
Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46Q27650923
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Histone methylation by PRC2 is inhibited by active chromatin marksQ27667743
Structure of HDAC3 bound to co-repressor and inositol tetraphosphateQ27676653
Insight into the Architecture of the NuRD Complex: STRUCTURE OF THE RbAp48-MTA1 SUBCOMPLEXQ27684304
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2Q27702306
Overview of the CCP4 suite and current developmentsQ27860782
Phasercrystallographic softwareQ27860930
Features and development of CootQ27861079
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complexQ28269256
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cellsQ28511395
EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin LandscapeQ28594870
EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem CellsQ28595041
Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutQ29301233
Jarid2 and PRC2, partners in regulating gene expressionQ33631152
Expression and purification of recombinant histones and nucleosome reconstitutionQ33914576
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogrammingQ34027556
NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repressionQ34029662
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatinQ34039391
Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complexQ34114615
H3K36 methylation antagonizes PRC2-mediated H3K27 methylationQ34624209
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.Q34964097
Dali server updateQ36004180
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.Q36609876
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.Q36859278
The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cellsQ36882704
Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.Q37217368
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.Q37465128
Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo functionQ37469454
Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purificationQ37599764
The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesisQ37706132
Role of PRC2-associated factors in stem cells and diseaseQ38255769
Nuclear phosphoinositide regulation of chromatin.Q39159757
A model for transmission of the H3K27me3 epigenetic markQ39927750
Nucleosome binding and histone methyltransferase activity of Drosophila PRC2.Q40110095
The structure of the core NuRD repression complex provides insights into its interaction with chromatin.Q40522477
Histone deacetylation: IP4 is an epigenetic coregulator.Q41857598
Jing: a downstream target of slbo required for developmental control of border cell migrationQ47072518
DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation.Q47421523
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.Q47617136
Polycomb-like proteins link the PRC2 complex to CpG islands.Q47859713
Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression.Q52771957
New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioningQ74352513
P433issue5
P304page(s)840-852.e5
P577publication date2018-03-01
P1433published inMolecular CellQ3319468
P1476titleUnique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
P478volume69

Reverse relations

cites work (P2860)
Q90681186A novel form of JARID2 is required for differentiation in lineage-committed cells
Q88582682Architecture of PRC2 Holo Complexes
Q93131954Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
Q92667844C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
Q61031838Capturing the Onset of PRC2-Mediated Repressive Domain Formation
Q92339999EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer
Q92882322EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
Q91216637Engaging chromatin: PRC2 structure meets function
Q90243494G-tract RNA removes Polycomb repressive complex 2 from genes
Q56525266Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits
Q92877922Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation
Q57799531Molecular basis for chromatin assembly and modification by multi-protein complexes
Q90108473Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity
Q92429871PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
Q92254249PRC2 is high maintenance
Q92129386RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2
Q93207151Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding
Q99638530Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19
Q92351847Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex
Q91641243hPCL3S promotes proliferation and migration of androgen-independent prostate cancer cells

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