[Obesity studies in candidate genes].

scientific article published in April 2004

[Obesity studies in candidate genes]. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0025-7753(04)74300-6
P698PubMed publication ID15117649

P50authorAmelia MartiQ47223163
P2093author name stringJ Alfredo Martínez
María del Carmen Ochoa
P2860cites workHuman beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor functionQ24561366
Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetesQ24564520
The G-308A variant of the Tumor Necrosis Factor-alpha (TNF-alpha) gene is not associated with obesity, insulin resistance and body fat distributionQ24804687
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humansQ28191413
Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE studyQ28201029
A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish populationQ28203578
Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesityQ28264342
Obesity associated with a mutation in a genetic regulator of adipocyte differentiationQ28283800
Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family StudyQ28362781
Uncoupling protein 3 and peroxisome proliferator-activated receptor gamma2 contribute to obesity and diabetes in palauansQ32125846
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetesQ33899154
A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitusQ33943770
The sympathetic nervous system and obesity: role in aetiology and treatmentQ34741897
The human obesity gene map: the 2002 updateQ35084465
The human obesity gene map: the 2003 updateQ35715184
Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian childrenQ35830761
An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes.Q39511136
Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese menQ73034893
Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidationQ73170888
Frequency of and interaction between polymorphisms in the beta3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in GermansQ73228428
Association of sets of alleles of genes encoding beta3-adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesityQ73510775
The beta 3-adrenergic receptor gene and obesity in a population sample of African AmericansQ73599728
A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activityQ73640736
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiencyQ73799823
Tumor necrosis factor-alpha--308 G/A polymorphism in obese CaucasiansQ73799897
Variation in the gene for human peroxisome proliferator activated receptor gamma (PPARgamma) does not play a major role in the development of morbid obesityQ73884891
Uncoupling protein 2 region on chromosome 11q13 is not linked to markers of obesity in familial type 2 diabetesQ73929169
Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican AmericansQ74200439
[Genetic studies of obesity in humans]Q74243280
Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesityQ74313824
Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitusQ74459280
Molecular screening of uncoupling protein 2 gene in patients with noninsulin-dependent diabetes mellitus or obesityQ77114119
The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in femalesQ77331640
Screening for variants of the uncoupling protein 2 gene in Japanese patients with non-insulin-dependent diabetes mellitusQ77779460
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjectsQ77924533
Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjectsQ78003957
The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.Q51549887
Circulating ghrelin levels are decreased in human obesity.Q51549919
Evidence for gene-nutrient interaction at the PPARgamma locus.Q51550350
Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women.Q51551577
Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men.Q51551763
Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men.Q51553957
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia.Q51566671
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.Q51568495
Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.Q51571842
Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.Q51672678
Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men.Q54095328
Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians.Q54102579
Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.Q54164957
Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism.Q54762887
Effect of Trp64Arg mutation of the β3‐adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor γ gene on obesity in Japanese childrenQ54777045
Pilot study examining the frequency of several gene polymorphisms in a morbidly obese population.Q54791585
Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjectsQ55162997
Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populationsQ57242012
Interactions among the α2-, β2-, and β3-adrenergic receptor genes and obesity-related phenotypes in the Quebec Family StudyQ57316425
DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohortsQ57316435
Linkage Between Markers in the Vicinity of the Uncoupling Protein 2 Gene and Resting Metabolic Rate in HumansQ57316444
Genetic factors as predictors of weight gain in young adult Dutch men and womenQ57418378
Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian populationQ57840328
Genetic Variation and Obesity in Australian Women: A Prospective StudyQ58647789
UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutationsQ58679006
TRP64ARG polymorphism of the beta3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyleQ59284112
Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese womenQ60472326
Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjectsQ61713509
Fat tissue accumulation during peritoneal dialysis is associated with a polymorphism in uncoupling protein 2Q61928062
The hormone-sensitive lipase i6 gene polymorphism and body fat accumulationQ63502701
Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor- Gene Are Associated with Severe Overweight among Obese WomenQ64355583
The Trp64Arg Polymorphism of the 3-Adrenergic Receptor Gene: Lack of association with NIDDM and features of insulin resistance syndromeQ64355585
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjectsQ72956092
Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.Q39556349
Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohortQ40625761
No relationship between identified variants in the uncoupling protein 2 gene and energy expenditureQ42460607
A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima IndiansQ42800233
Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohortQ42811435
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesityQ43542493
G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretionQ43601844
Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohortQ43667388
Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjectsQ43709078
The Arg16Gly polymorphism of human beta2-adrenoreceptor is associated with type 2 diabetes in Taiwanese peopleQ43742365
A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic functionQ43748969
Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding.Q43771731
Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance.Q43803927
The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activityQ43819862
The TNF alpha/G-308A polymorphism influences insulin sensitivity in offspring of patients with coronary heart disease: the European Atherosclerosis Research Study II.Q43912967
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patientsQ43943750
Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesityQ43990202
Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjectsQ44037426
Beta(2)-adrenergic receptor mutation and abdominal obesity risk: effect modification by gender and HDL-cholesterolQ44058782
The risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor: effect modification by age.Q44095985
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitusQ44129704
Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma2 gene in healthy individuals.Q44158440
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish populationQ44172019
Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic SyndromeQ44183775
The influence of the Pro12Ala mutation of the PPAR-gamma receptor gene on metabolic and clinical characteristics in treatment-naïve patients with type 2 diabetesQ44198031
A maximal effort trial in obese women carrying the beta2-adrenoceptor Gln27Glu polymorphism.Q44218784
The polymorphism of the beta3-adrenergic receptor gene is associated with reduced low-density lipoprotein particle sizeQ44368980
Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjectsQ44392900
A 45‐bp Insertion/Deletion Polymorphism of Uncoupling Protein 2 in Relation to Obesity in TongansQ44400038
CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARgamma geneQ44439174
Analysis of the Relationship between PPAR-γ 2 Gene Variants and Severe Insulin Resistance in Obese Patients with Impaired Glucose ToleranceQ44440946
The TNF-alpha gene NcoI polymorphism at position -308 of the promoter influences insulin resistance, and increases serum triglycerides after postprandial lipaemia in familiar obesity.Q44441370
The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesityQ44509851
Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men.Q44997850
Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family StudyQ46347272
Racial differences in the relation between uncoupling protein genes and resting energy expenditureQ46485912
No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal womenQ47184694
An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men.Q47248348
Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish womenQ47274507
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.Q47700926
Human hormone-sensitive lipase: genetic mapping, identification of a new dinucleotide repeat, and association with obesity and NIDDM.Q48039334
Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 younQ50567719
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns.Q50896734
Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study.Q51536333
Role of ghrelin polymorphisms in obesity based on three different studies.Q51541254
Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator-activated receptor-gamma2 genes and obesity.Q51549578
P433issue14
P407language of work or nameSpanishQ1321
P921main subjectobesityQ12174
P304page(s)542-551
P577publication date2004-04-01
P1433published inMedicina clínicaQ26854009
P1476title[Obesity studies in candidate genes].
P478volume122

Reverse relations

cites work (P2860)
Q57599356ADRB3andPPARγ2gene polymorphisms and their association with cardiovascular disease risk in postmenopausal women
Q46222038G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects
Q58075052Gene–gene interaction between PPARγ2 and ADRβ3 increases obesity risk in children and adolescents
Q28581080High-fat feeding period affects gene expression in rat white adipose tissue
Q55032731Individual Responsiveness to Exercise-Induced Fat Loss and Improvement of Metabolic Profile in Young Women is Associated with Polymorphisms of Adrenergic Receptor Genes.
Q59283484Interaction between genes and lifestyle factors on obesity
Q54302905Leptin receptor gene K656N polymorphism is associated with low body fat levels and elevated high-density cholesterol levels in Mexican children and adolescents.