Abstract is: Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory models in preclinical applications. Calu-3 cells were first derived in 1975 by Germain Trempe and Jorgen Fogh of the Memorial Sloan Kettering Cancer Center. The cells were isolated from the pleural effusion of a 25-year-old Caucasian male with a lung adenocarcinoma. The Calu-3 cell line grows as an adherent monolayer and overexpresses the ERBB2 gene, leading to active ErbB2/Her2. The cells also express CK7, occludin, and E-cadherin. Calu-3 cells also have large amounts of cystic fibrosis transmembrane conductance regulator. Calu-3 cells are commonly used as both in vitro and in vivo models for drug development against lung cancer. The cells have been used in studies of pulmonary drug delivery, demonstrating a capacity to intake low molecular weight substances. Calu-3 cells have served as respiratory models for air intake and lung injury due to their responsiveness to foreign substances. The Calu-3 cell line has shown to be useful in the study of chloride ion secretion by lung epithelial cells. The cells may be used in high-throughput screening applications focused on barrier integrity and surface protein expression of lung cells.
| cell line | Q21014462 |
| cancer cell line | Q23058136 |
| P2158 | Cell Line Ontology ID | CLO_0002192 |
| P3289 | Cellosaurus ID | CVCL_0609 |
| P2888 | exact match | http://purl.obolibrary.org/obo/BTO_0002750 |
| http://purl.obolibrary.org/obo/CLO_0002192 | ||
| http://purl.obolibrary.org/obo/EFO_0002819 | ||
| P2671 | Google Knowledge Graph ID | /g/11f60xx489 |
| P9072 | derived from organism type | Homo sapiens | Q15978631 |
| P1343 | described by source | One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23 | Q28294341 |
| A mass spectrometric-derived cell surface protein atlas | Q28546580 | ||
| Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer | Q29547564 | ||
| The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity | Q29547693 | ||
| A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers | Q30434796 | ||
| Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection | Q33525586 | ||
| Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays | Q33882864 | ||
| A gene-alteration profile of human lung cancer cell lines. | Q33978771 | ||
| Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay | Q34661407 | ||
| Established cell lines used in cystic fibrosis research | Q35908460 | ||
| TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression | Q36301828 | ||
| Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice | Q36497106 | ||
| A landscape of pharmacogenomic interactions in cancer. | Q37140236 | ||
| Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring | Q37307952 | ||
| A comprehensive transcriptional portrait of human cancer cell lines | Q37854720 | ||
| A resource for cell line authentication, annotation and quality control | Q38886793 | ||
| The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function | Q38923770 | ||
| Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. | Q39282659 | ||
| Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma | Q39691637 | ||
| Signatures of mutation and selection in the cancer genome | Q39737975 | ||
| The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer | Q39893596 | ||
| Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification | Q40136484 | ||
| Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery | Q40844143 | ||
| Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion | Q41472185 | ||
| Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins. | Q42802468 | ||
| Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. | Q52313314 | ||
| Human tumor lines for cancer research | Q52826141 | ||
| Polymorphic enzyme analysis of cultured human tumor cell lines | Q52826513 | ||
| Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium | Q52826622 | ||
| Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells | Q52828045 | ||
| Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas | Q70385271 | ||
| Next-generation characterization of the Cancer Cell Line Encyclopedia | Q91865441 | ||
| An Interactive Resource to Probe Genetic Diversity and Estimated Ancestry in Cancer Cell Lines | Q92510255 | ||
| P5166 | established from medical condition | adenocarcinoma of the lung | Q843799 |
| Q37854720 | A comprehensive transcriptional portrait of human cancer cell lines |
| Q33978771 | A gene-alteration profile of human lung cancer cell lines. |
| Q30434796 | A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers |
| Q37140236 | A landscape of pharmacogenomic interactions in cancer. |
| Q28546580 | A mass spectrometric-derived cell surface protein atlas |
| Q40136484 | Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification |
| Q41472185 | Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion |
| Q33882864 | Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays |
| Q40844143 | Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery |
| Q35908460 | Established cell lines used in cystic fibrosis research |
| Q52826622 | Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium |
| Q52826141 | Human tumor lines for cancer research |
| Q37307952 | Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring |
| Q52828045 | Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells |
| Q28294341 | One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23 |
| Q52826513 | Polymorphic enzyme analysis of cultured human tumor cell lines |
| Q42802468 | Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins. |
| Q39282659 | Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. |
| Q29547693 | The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity |
| Q38923770 | The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function |
| Q82069695 | SARS-CoV-2 | host | P2975 |
| Q109117032 | The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner | main subject | P921 |
| Calu-3 | wikipedia | |
| Calu-3 | wikipedia | |
| Calu-3細胞 | wikipedia |
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