Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.

scientific article published in December 2000

Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1432-1327.2000.01815.X
P698PubMed publication ID11106424
P5875ResearchGate publication ID12222484

P2093author name stringR Jover
F Hoffmann
R L Lindberg
V Scheffler-Koch
P2860cites workCleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinaseQ28299534
Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyriaQ33849564
Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor.Q33865155
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellumQ34320881
Antipyrine metabolism in acute hepatic porphyria in relapse and remissionQ34416774
Phenobarbital induction of cytochrome P-450 gene expressionQ35887158
Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNAQ38325530
A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liverQ38346927
2,3,7,8-Tetrachlorodibenzo-p-dioxin: a potent inducer of -aminolevulinic acid synthetaseQ38588495
Haem as a multifunctional regulatorQ38767983
Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1.Q39575132
Metals as Regulators of Heme MetabolismQ39711590
Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.Q40384078
Chemistry and biology of heme. Effect of metal salts, organometals, and metalloporphyrins on heme synthesis and catabolism, with special reference to clinical implications and interactions with cytochrome P-450.Q40884181
Nitric oxide synthase: role as a transmitter/mediator in the brain and endocrine systemQ41036351
Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancerQ41344783
The heme oxygenase system: a regulator of second messenger gasesQ41455806
Acute porphyrias: pathogenesis of neurological manifestationsQ41727540
Conversion of 5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick embryoQ42137138
Regulation of the stability of chicken embryo liver delta-aminolevulinate synthase mRNA by heminQ42198539
Heme may not be a positive regulator of cytochrome-P450 gene expressionQ42202933
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.Q42226100
Chemically induced porphyria: increased microsomal heme turnover after treatment with allylisopropylacetamideQ42238955
Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liverQ42275844
Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell culturesQ42548667
Regulation of CYP 2 A 5 induction by porphyrinogenic agents in mouse primary hepatocytesQ42551430
Involvement of heme in the transcriptional activation of CYPIIB1/B2 gene by phenobarbitone in rat liver--studies with succinylacetoneQ43877518
A simple and sensitive assay of 7-ethoxycoumarin deethylationQ46527161
Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and in healthy men.Q51630177
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver.Q54421111
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyriaQ57083724
Intermittent Acute Porphyria — Demonstration of a Genetic Defect in Porphobilinogen MetabolismQ67224654
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcriptionQ67981471
Microassay of heme oxygenase by high-performance liquid chromatography: Application to assay of needle biopsies of human liverQ68445464
Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrixQ68604315
Coordinate elevations of liver delta-aminolevulinate synthase and cytochrome P-450 RNA by phenobarbital in chicken embryos: the effects of hemeQ69393722
Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte cultureQ71037353
Liver injury and expression of cytochromes P450: evidence that regulation of CYP2A5 is different from that of other major xenobiotic metabolizing CYP enzymesQ71134979
Hemin inhibits transfer of pre-delta-aminolevulinate synthase into chick embryo liver mitochondriaQ71163685
Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrinsQ71513487
Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesisQ71530372
Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric statesQ72677054
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)7128-7137
P577publication date2000-12-01
P1433published inFEBS JournalQ1388041
P1476titleLimited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.
P478volume267

Reverse relations

cites work (P2860)
Q37702262A role for CYP in the drug-hormone crosstalk of the brain
Q40491304Adenoviral-mediated expression of porphobilinogen deaminase in liver restores the metabolic defect in a mouse model of acute intermittent porphyria
Q34520894Biochemical characterization of porphobilinogen deaminase-deficient mice during phenobarbital induction of heme synthesis and the effect of enzyme replacement
Q91687105Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP
Q34555359Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal
Q46819729Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency
Q30711956Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).
Q42552831Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease
Q35199452Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver
Q40395453Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH.
Q44643518Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice
Q35083817Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool
Q33754847Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone
Q51071328Hepatocyte transplantation ameliorates the metabolic abnormality in a mouse model of acute intermittent porphyria.
Q28191295Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase
Q44237138Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity
Q80768153Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation
Q91028537Sex differences in vascular reactivity in mesenteric arteries from a mouse model of acute intermittent porphyria
Q36099555Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in response to different nutrients
Q82332286[Reversible cerebrovascular event during an acute porphyric crisis. A case report]