Fostamatinib for the Treatment of Adult Persistent and Chronic Immune Thrombocytopenia: Results of Two Phase 3, Randomized, Placebo-Controlled Trials.

scientific article published on 26 April 2018

Fostamatinib for the Treatment of Adult Persistent and Chronic Immune Thrombocytopenia: Results of Two Phase 3, Randomized, Placebo-Controlled Trials. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/AJH.25125
P932PMC publication ID6055608
P698PubMed publication ID29696684

P50authorJames Bruce BusselQ1680075
Andrzej HellmannQ9152201
Francesco ZajaQ57307002
Jerzy WindygaQ87941922
Jacek TrelinskiQ96097159
Alhossain A KhalafallahQ47275556
P2093author name stringNichola Cooper
Donald M Arnold
Hany Zayed
Jiří Mayer
Anne-Marie Duliege
Liliya Sivcheva
Vadim Markovtsov
Wojciech Homenda
Elliot Grossbard
P2860cites workImmune thrombocytopeniaQ26830918
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Fostamatinib for persistent/chronic adult immune thrombocytopenia.Q54144290
Effects of fostamatinib, an oral spleen tyrosine kinase inhibitor, in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group studQ54322103
Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis.Q54488975
OSKIRA-4: a phase IIb randomised, placebo-controlled study of the efficacy and safety of fostamatinib monotherapyQ57752299
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid ArthritisQ28294375
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopeniaQ28305486
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophagesQ28634082
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The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet countsQ33332742
The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpuraQ33360255
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Rituximab in the management of chronic immune thrombocytopenic purpura: an effective and safe therapeutic alternative in refractory patients.Q33370619
The immune thrombocytopenic purpura (ITP) bleeding score: assessment of bleeding in patients with ITP.Q33375450
Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP).Q33376235
Self-reported health-related quality of life in adults with chronic immune thrombocytopenic purpuraQ33376373
Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpuraQ33377602
Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trialQ33378523
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working groupQ33381983
Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk.Q33382517
Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trialQ33383374
Corticosteroid side-effects and risk for bleeding in immune thrombocytopenic purpura: patient and hematologist perspectivesQ33384139
Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndromeQ33385999
Patient-reported treatment burden of chronic immune thrombocytopenia therapiesQ33400348
A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopeniaQ33415133
The SYK tyrosine kinase: a crucial player in diverse biological functionsQ36662082
The contribution of VEGF signalling to fostamatinib-induced blood pressure elevationQ38925714
Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trialsQ40699579
In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinibQ41773428
Prevention of fostamatinib-induced blood pressure elevation by antihypertensive agentsQ43203308
TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosisQ44968896
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trialQ46271720
A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonistQ46568872
Splenectomy for Immune Thrombocytopenia: Down but not out.Q47754303
GPIIb/IIIa autoantibody predicts better rituximab response in ITP.Q48100314
Physician Decision Making in Selection of Second-Line Treatments in Immune Thrombocytopenia in Children.Q52320502
P433issue7
P921main subjectthrombocytopeniaQ585285
chronic immune thrombocytopeniaQ1088037
phase III clinical trialQ42824827
P304page(s)921-930
P577publication date2018-05-15
P1433published inAmerican Journal of HematologyQ4744246
P1476titleFostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials
P478volume93

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