Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.

scientific article published on 17 April 2018

Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JCMM.13632
P932PMC publication ID6010703
P698PubMed publication ID29665227

P50authorKrzysztof WarzochaQ11749787
Ewa Lech-MarańdaQ88435517
Michał GałęzowskiQ114330797
Tomasz SewastianikQ114419563
Wojciech CzardybonQ114419564
Hanna Makuch-ŁasicaQ125311120
Patryk GórniakQ59566760
Emilia BiałopiotrowiczQ59691213
Anna PolakQ59705325
Ewa JabłońskaQ59705333
Przemysław JuszczyńskiQ59705355
Katarzyna BorgQ59707377
Bozena Katarzyna BudziszewskaQ85253808
Maciej SzydlowskiQ86744691
Bartosz PulaQ57028177
P2093author name stringKrzysztof Brzózka
Renata Windak
Aleksandra Bluszcz
Monika Noyszewska-Kania
Grażyna Nowak
Karolina Piechna
Maja Wasylecka-Juszczyńska
P2860cites workPim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levelsQ24309167
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismQ24603034
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell deathQ28204906
PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cellsQ28237807
Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphomaQ28275416
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migrationQ33494281
Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cellsQ33749658
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cellsQ33830733
Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cellsQ73407146
Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagementQ73900277
Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiationQ81082199
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemiaQ34542102
Regulation of Mcl-1 expression in context to bone marrow stromal microenvironment in chronic lymphocytic leukemiaQ35022490
Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivoQ35781372
Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule InhibitorsQ36383040
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survivalQ36384731
JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemiaQ36544062
Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survivalQ36561705
BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemiaQ36799197
4E-BP1, a multifactor regulated multifunctional proteinQ36838384
The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.Q37035832
STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.Q37362593
Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cellsQ37414714
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemiaQ37564783
From pathogenesis to treatment of chronic lymphocytic leukaemiaQ37643423
The Pim kinases: new targets for drug developmentQ37903357
Chronic lymphocytic leukaemia--the role of the microenvironment pathogenesis and therapyQ38101683
"Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia''.Q38140625
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylationQ38266874
PIM kinase (and Akt) biology and signaling in tumors.Q38370023
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatmentQ38550810
Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.Q38683489
Prognostic Factors for Chronic Lymphocytic LeukemiaQ38691341
Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.Q38813901
Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks.Q38960311
PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1).Q39012615
Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphomaQ39283981
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cellsQ39562043
Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.Q39844632
FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas.Q41111760
Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenibQ41763842
Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Q42319925
Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogeneQ46879250
Increased expression of E3 ubiquitin ligases targeting p53 in CLL patients with wild-type TP53 exhibits associations with clinical features of the disease.Q53329470
P433issue7
P921main subjectlymphocyteQ715347
leukemiaQ29496
chronic lymphocytic leukemiaQ1088156
P304page(s)3548-3559
P577publication date2018-04-17
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleMicroenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration
P478volume22

Reverse relations

cites work (P2860)
Q58738700CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton's tyrosine kinase
Q91684508Characteristics of live parameters of the HS-5 human bone marrow stromal cell line cocultured with the leukemia cells in hypoxia, for the studies of leukemia-stroma cross-talk
Q61798674Molecular Players in Hematologic Tumor Cell Trafficking
Q90705620Platelet-derived growth factor-BB promotes proliferation and migration of retinal microvascular pericytes by up-regulating the expression of C-X-C chemokine receptor types 4

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