Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis.

scientific article published on 20 March 2018

Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.5483/BMBREP.2018.51.5.046
P932PMC publication ID5988581
P698PubMed publication ID29555015

P50authorHyunki KimQ59679946
Sung Hoon NohQ59694457
Ho-Geun YoonQ60677777
Soo-Yeon ParkQ61142958
Jae-Ho CheongQ63644867
Hyun Jung KeeQ87238771
P2093author name stringJae Eun Lee
Seung-Hyun Lee
Yoon Young Choi
Kyung-Chul Choi
Jaesung Seo
Mi-Hyeon Jeong
Hye Ji Choi
Garam Guk
SooYeon Lee
P2860cites workWntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cellsQ24329073
Secretion of Wnt ligands requires Evi, a conserved transmembrane proteinQ24329123
Wnt/β-catenin signaling and diseaseQ26823272
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trialQ27853380
WLS retrograde transport to the endoplasmic reticulum during Wnt secretionQ28115924
WNT signalling pathways as therapeutic targets in cancerQ29615666
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trialQ29620917
Gpr177 regulates pulmonary vasculature developmentQ30410961
Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesisQ31112063
Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatmentQ33695152
Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesisQ33949717
Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cellsQ34126349
Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain developmentQ34664018
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndromeQ35149624
Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapyQ35154288
Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouseQ35157491
Can we safely target the WNT pathway?Q35591995
Metabolic stress induces a Wnt-dependent cancer stem cell-like state transitionQ36293834
Precise regulation of porcupine activity is required for physiological Wnt signaling.Q36298362
Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer.Q36633405
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cellsQ37305230
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Q37395251
Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5Q37554563
Wnt/β-catenin signalling: from plasma membrane to nucleusQ38076192
Genetics and Molecular Pathogenesis of Gastric AdenocarcinomaQ38527516
How Can Gastric Cancer Molecular Profiling Guide Future Therapies?Q38853530
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesisQ39432100
MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinomaQ48503700
Wls promotes the proliferation of breast cancer cells via Wnt signaling.Q53568356
P433issue5
P304page(s)255-260
P577publication date2018-05-01
P1433published inBMB ReportsQ15764027
P1476titleInhibition of Wntless/GPR177 suppresses gastric tumorigenesis
P478volume51

Reverse relations

cites work (P2860)
Q92994187G protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastric cancer
Q93379565Prognostic values of E2F mRNA expression in human gastric cancer

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