| scholarly article | Q13442814 |
| P50 | author | Colleen M. Niswender | Q67215380 |
| Craig W. Lindsley | Q67215429 | ||
| P. Jeffrey Conn | Q67215432 | ||
| Hyekyung P Cho | Q114738627 | ||
| P2093 | author name string | Andrew S Felts | |
| Charles S Elmore | |||
| Daniel E O'Brien | |||
| Steven S Wesolowski | |||
| Jonas Bergare | |||
| Alan J Cross | |||
| Douglas M Shaw | |||
| P2860 | cites work | Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS | Q24629746 |
| The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys | Q27325802 | ||
| Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression | Q28253233 | ||
| CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding | Q28370513 | ||
| Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents | Q30406145 | ||
| Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity | Q30535764 | ||
| Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction | Q30619467 | ||
| [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. | Q34190616 | ||
| Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. | Q34263938 | ||
| A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain | Q34293120 | ||
| Development of allosteric modulators of GPCRs for treatment of CNS disorders | Q34373958 | ||
| Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders | Q34399823 | ||
| Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor | Q34437261 | ||
| A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity | Q34445862 | ||
| Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation | Q34468639 | ||
| Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice | Q34512857 | ||
| A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators | Q34518807 | ||
| A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors | Q34617039 | ||
| A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis | Q34631718 | ||
| Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles | Q34907032 | ||
| Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA. | Q34978304 | ||
| Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. | Q35688485 | ||
| Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model. | Q35988776 | ||
| Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships | Q36335613 | ||
| Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. | Q36755346 | ||
| Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology. | Q36880915 | ||
| Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders | Q37360436 | ||
| Metabotropic glutamate receptors: physiology, pharmacology, and disease | Q37670222 | ||
| Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target | Q38044784 | ||
| Analytical pharmacology and allosterism: the importance of quantifying drug parameters in drug discovery | Q38139544 | ||
| Advances in G protein-coupled receptor allostery: from function to structure | Q38233848 | ||
| Quantitative analysis of receptor allosterism and its implication for drug discovery | Q38451155 | ||
| The mass action equation in pharmacology | Q38617373 | ||
| Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators | Q38649976 | ||
| Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators | Q38755530 | ||
| Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284. | Q38759673 | ||
| Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2. | Q39062474 | ||
| Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs | Q39077987 | ||
| Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects | Q39700845 | ||
| Modulation of group III metabotropic glutamate receptors by hydrogen ions | Q39907703 | ||
| Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site | Q39989334 | ||
| A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors | Q40028879 | ||
| Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia | Q41864251 | ||
| Co-operative binding assay for the characterization of mGlu4 allosteric modulators. | Q41887461 | ||
| Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222. | Q42700069 | ||
| Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782. | Q42710710 | ||
| Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging | Q48370728 | ||
| What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2. | Q48598082 | ||
| What is pharmacological 'affinity'? Relevance to biased agonism and antagonism. | Q53149817 | ||
| Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors | Q60717148 | ||
| P433 | issue | 5 | |
| P304 | page(s) | 526-540 | |
| P577 | publication date | 2018-03-15 | |
| P1433 | published in | Molecular Pharmacology | Q1943386 |
| P1476 | title | Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators. | |
| P478 | volume | 93 |
| Q64903522 | Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. | cites work | P2860 |
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