Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila.

scientific article published in March 2007

Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0301-07.2007
P8608Fatcat IDrelease_db3zvi2firelrmm3vzenxdaaom
P932PMC publication ID6672108
P698PubMed publication ID17392474

P50authorGreg J BashawQ89598501
P2093author name stringDavid S Garbe
P2860cites workSlit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidanceQ22009125
Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cordQ24290198
Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptorsQ24336174
Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptorQ28140658
Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complexQ28203651
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axonsQ28509522
Conserved roles for Slit and Robo proteins in midline commissural axon guidanceQ28513027
Rho GTPases in growth cone guidanceQ28647606
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous systemQ29616040
The molecular biology of axon guidanceQ29617857
Slit proteins: key regulators of axon guidance, axonal branching, and cell migrationQ33840691
Slit is the midline repellent for the robo receptor in Drosophila.Q33856788
Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Q33932154
C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.Q34095410
Comm sorts robo to control axon guidance at the Drosophila midline.Q34146642
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.Q34332258
Dynamic regulation of axon guidance.Q34425373
Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midlineQ34455585
Slit-roundabout signaling neutralizes netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathwaysQ34573256
Axon guidance at the midline: from mutants to mechanismsQ36069368
eagle, a member of the steroid receptor gene superfamily, is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS.Q36798436
The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins Eagle and Huckebein.Q39448810
The embryonic central nervous system lineages of Drosophila melanogaster. II. Neuroblast lineages derived from the dorsal part of the neuroectoderm.Q39453065
Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsionQ41678046
Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation.Q46004298
Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs.Q46053403
commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane proteinQ46214092
The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in DrosophilaQ46404564
Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons.Q46466543
Function and specificity of LIM domains in Drosophila nervous system and wing developmentQ46523504
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC functionQ46765318
Commissure formation in the embryonic CNS of Drosophila.Q47069950
Netrins guide Drosophila commissural axons at short range.Q47070391
beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS.Q47070657
frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance.Q47071119
ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized NetrinQ47072362
Crossing the midline: roles and regulation of Robo receptorsQ47072859
Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologsQ48061605
Change in chemoattractant responsiveness of developing axons at an intermediate targetQ48558617
The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution.Q52165554
The embryonic central nervous system lineages of Drosophila melanogaster. I. Neuroblast lineages derived from the ventral half of the neuroectoderm.Q52199402
Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets.Q52573588
P4510describes a project that usesImageJQ1659584
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)3584-3592
P577publication date2007-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleIndependent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila
P478volume27

Reverse relations

cites work (P2860)
Q33336389A concerted action of Engrailed and Gooseberry-Neuro in neuroblast 6-4 is triggering the formation of embryonic posterior commissure bundles
Q33834786A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance
Q34092800Axon guidance at the midline: of mice and flies.
Q47448307Control of nerve cord formation by Engrailed and Gooseberry-Neuro: A multi-step, coordinated process.
Q36918092Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
Q33847359Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance
Q37266626Dscam guides embryonic axons by Netrin-dependent and -independent functions
Q28554278Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons
Q47071898Frazzled regulation of myosin II activity in the Drosophila embryonic CNS.
Q34065418Frazzled/DCC facilitates cardiac cell outgrowth and attachment during Drosophila dorsal vessel formation
Q35756043Hydroxyurea-mediated neuroblast ablation establishes birth dates of secondary lineages and addresses neuronal interactions in the developing Drosophila brain
Q33547449In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS.
Q37200696Midline governs axon pathfinding by coordinating expression of two major guidance systems
Q47685682Motor axons are guided to exit points in the spinal cord by Slit and Netrin signals
Q30389570Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction
Q47968291Motor neuron migration and positioning mechanisms: New roles for guidance cues
Q39672366Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.
Q50669819Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
Q37272801Netrin, Slit and Wnt receptors allow axons to choose the axis of migration.
Q39822415Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons.
Q30494803Netrin-guided accessory cell morphogenesis dictates the dendrite orientation and migration of a Drosophila sensory neuron
Q35968151Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain
Q24647738Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals
Q33986090Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion.
Q37085907Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylation.
Q41268274The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline.
Q36080479unfulfilled interacting genes display branch-specific roles in the development of mushroom body axons in Drosophila melanogaster

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