Directed evolution of a synthetic phylogeny of programmable Trp repressors.

scientific article published on 26 February 2018

Directed evolution of a synthetic phylogeny of programmable Trp repressors. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41589-018-0006-7
P698PubMed publication ID29483643

P50authorJared W EllefsonQ87889124
P2093author name stringAndrew D Ellington
Michael P Ledbetter
P2860cites workProtein-DNA recognitionQ22065421
The tryptophan repressor sequence is highly conserved among the EnterobacteriaceaeQ24609754
The complete nucleotide sequence of the tryptophan operon of Escherichia coliQ24633839
Molecular archaeology of the Escherichia coli genomeQ24681270
The ensemble nature of allosteryQ26862004
Mapping the environmental fitness landscape of a synthetic gene circuitQ27331437
Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymesQ27728185
Crystal structure of trp repressor/operator complex at atomic resolutionQ27728594
The solution structures of the trp repressor-operator DNA complexQ27731312
Tandem binding in crystals of a trp repressor/operator half-site complexQ27731454
Attenuation in the control of expression of bacterial operonsQ28276746
Molecular biology of the LysR family of transcriptional regulatorsQ29615198
High-throughput metabolic engineering: advances in small-molecule screening and selectionQ33549481
Gel retardation at low pH resolves trp repressor-DNA complexes for quantitative studyQ33551865
The crystal structure of trp aporepressor at 1.8 A shows how binding tryptophan enhances DNA affinityQ34185180
Genomic mining of prokaryotic repressors for orthogonal logic gatesQ34194331
The three-dimensional structure of trp repressor.Q34194439
Principles of genetic circuit designQ34502550
Production and biological activity of rebeccamycin, a novel antitumor agent.Q34685566
Evolution-guided optimization of biosynthetic pathwaysQ34752504
The role of mobile genetic elements in bacterial adaptation to xenobiotic organic compoundsQ35172600
Ancient origin of the tryptophan operon and the dynamics of evolutionary changeQ35215943
SYNTHETIC BIOLOGY. Emergent genetic oscillations in a synthetic microbial consortiumQ36136105
Nucleotide sequence and expression of Escherichia coli trpR, the structural gene for the trp aporepressorQ36418236
Tryptophan operon regulation in interspecific hybrids of enteric bacteriaQ36582462
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptationQ37203938
Structure and function of the LysR-type transcriptional regulator (LTTR) family proteinsQ37338823
A synthetic genetic edge detection program.Q37417032
Genetic programs constructed from layered logic gates in single cellsQ37522771
Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA.Q37675083
Engineering signal transduction pathwaysQ37677850
The stereochemistry and biochemistry of the trp repressor-operator complexQ37912739
Mutant Trp repressors with new DNA-binding specificitiesQ38346283
Bacteriophage T7 early promoters: nucleotide sequences of two RNA polymerase binding sitesQ38359991
Evolution of transcription factors and the gene regulatory network in Escherichia coliQ39735217
Sequence analysis of operator constitutive mutants of the tryptophan operon of Escherichia coliQ40901723
Synthetic biosensors for precise gene control and real-time monitoring of metabolitesQ41874589
Directed evolution of genetic parts and circuits by compartmentalized partnered replicationQ42258092
Interaction of the trp repressor and RNA polymerase with the trp operonQ43675458
A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venomQ46083732
A synthetic multicellular system for programmed pattern formationQ46461387
DNA specificity determinants of Escherichia coli tryptophan repressor bindingQ46531052
Dynamic metabolic engineering for increasing bioprocess productivityQ47590195
Evolving Orthogonal Suppressor tRNAs To Incorporate Modified Amino Acids.Q51170988
Construction and characterization of monomeric tryptophan repressor: a model for an early intermediate in the folding of a dimeric protein.Q54560087
Hemoglobin S antigelation agents based on 5-bromotryptophan with potential for sickle cell anemiaQ68632487
In vivo and in vitro studies of TrpR-DNA interactionsQ71039716
P433issue4
P921main subjectphylogeneticsQ171184
directed evolutionQ440681
P1104number of pages7
P304page(s)361-367
P577publication date2018-02-26
P1433published inNature Chemical BiologyQ904026
P1476titleDirected evolution of a synthetic phylogeny of programmable Trp repressors
P478volume14

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cites work (P2860)
Q89542051An autoinducible trp-T7 expression system for production of proteins and biochemicals in Escherichia coli
Q97424536Cell-free biosensors for rapid detection of water contaminants
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Q91671407Directed evolution of the PcaV allosteric transcription factor to generate a biosensor for aromatic aldehydes
Q99207479Engineered systems of inducible anti-repressors for the next generation of biological programming
Q93382220Escherichia coli "Marionette" strains with 12 highly optimized small-molecule sensors
Q91070610Stimulus response-based fine-tuning of polyhydroxyalkanoate pathway in Halomonas
Q64059464Synthetic biology for evolutionary engineering: from perturbation of genotype to acquisition of desired phenotype
Q92826707Synthetic evolution
Q52684311Trp-ing upon new repressors.

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