Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.

scientific article published on 22 February 2018

Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.RA117.000741
P932PMC publication ID5900774
P698PubMed publication ID29472293

P2093author name stringKanae Yumimoto
Keiichi I Nakayama
Atsuki Kawamura
Shogo Nakayama
P2860cites workMYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genesQ21090170
CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesisQ21134800
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Purification of oligodendrocyte lineage cells from mouse cortices by immunopanningQ44731877
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligaseQ45057145
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell sizeQ45118851
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligaseQ46603785
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).Q46626421
CHD8 haploinsufficiency results in autistic-like phenotypes in miceQ47394890
p53-Altered FBXW7 expression determines poor prognosis in gastric cancer casesQ48008325
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.Q51898177
Comprehensive identification of substrates for F-box proteins by differential proteomics analysisQ83959951
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-cateninQ24534109
Systematic analysis and nomenclature of mammalian F-box proteinsQ24561715
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal developmentQ24616861
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexQ24655274
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelinationQ24657511
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesisQ24658335
The ubiquitin systemQ27860803
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapseQ28115583
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell linesQ28188140
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell lineQ28188152
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptorQ28203706
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homologQ28207494
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligaseQ28215069
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signalingQ28240232
Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNSQ28274507
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteinsQ28512956
Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegansQ28623285
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and functionQ29547320
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiationQ29616127
Ubiquitin: structures, functions, mechanismsQ29616462
Ubiquitin ligases: cell-cycle control and cancerQ29617992
Toddler: an embryonic signal that promotes cell movement via Apelin receptorsQ30584600
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifsQ33897957
The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradationQ33977574
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phaseQ34365993
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradationQ34835596
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in miceQ35562476
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.Q35917801
jPOSTrepo: an international standard data repository for proteomesQ36207294
Fbxw7 Limits Myelination by Inhibiting mTOR Signaling.Q36254079
F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.Q39108673
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferationQ39702451
TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesisQ40666297
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cellsQ41867595
Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junctionQ42198974
P4510describes a project that usesImageJQ1659584
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)5705-5714
P577publication date2018-02-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleDegradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
P478volume293

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cites work (P2860)
Q64108794GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
Q92575313Novel truncation mutations in MYRF cause autosomal dominant high hyperopia mapped to 11p12-q13.3.

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