Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.

scientific article published on 3 May 2018

Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1103748959
P356DOI10.1038/S41388-018-0277-1
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/s41388-018-0277-1
P932PMC publication ID6072706
P698PubMed publication ID29720725

P50authorSebastian BrandnerQ58333540
Matthew EllisQ61203162
Ying ZhangQ85408485
P2093author name stringJoanne Lau
Paul Frankel
Ningning Li
Kastytis Sidlauskas
Angela Richard-Loendt
Ian Evans
Jessica Broni
Loredana Guglielmi
Tedani El-Hassan
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miR-449b inhibits the proliferation of SW1116 colon cancer stem cells through downregulation of CCND1 and E2F3 expressionQ39151989
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Q46410671
microRNA-449 is a putative regulator of choroid plexus development and function.Q47035992
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Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitroQ47931157
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.Q48117008
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiationQ33733341
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAsQ33742561
Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesisQ33925986
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Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brainQ34697339
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosisQ35015916
Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent mannerQ35105147
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MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targetsQ35809301
IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.Q35845197
A potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer.Q35857169
MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex developmentQ36154268
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MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cellsQ36959452
SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursorsQ37088685
MiR-449a promotes breast cancer progression by targeting CRIP2.Q37109894
Pten haploinsufficiency accelerates formation of high-grade astrocytomasQ37384874
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.Q37393628
Increased miR-449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigenQ37437986
Molecular neuro-oncology in clinical practice: a new horizonQ38125031
Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneityQ38179962
G protein-coupled receptor mutations and human genetic diseaseQ38242603
microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest.Q38300511
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse GliomaQ38453759
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)4313-4333
P577publication date2018-05-03
P1433published inOncogeneQ1568657
P1476titleInhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.
P478volume37

Reverse relations

cites work (P2860)
Q91732486GATAD1 gene amplification promotes glioma malignancy by directly regulating CCND1 transcription
Q90165841Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas
Q64108747MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer
Q57796325RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss
Q100430026miRNA signature in glioblastoma: Potential biomarkers and therapeutic targets

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