Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal.

scientific article published on 17 April 2018

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1103418590
P356DOI10.1186/S12885-018-4344-3
P8608Fatcat IDrelease_ncw7iblhvrafhbyzbhia3eyd3m
P932PMC publication ID5902941
P698PubMed publication ID29665787

P2093author name stringLiang Li
Yueran Zhao
Xiaopeng Lan
Yougen Chen
Qinghua Xia
Miaoqing Zhao
Zhongxian Huang
Muyun Wei
Guoliang Lu
Shaowei Mao
P2860cites workMedication use and survival in diabetic patients with kidney cancer: A population-based cohort study.Q51764018
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Valproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4.Q53410584
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Metformin Use and Outcome of Sunitinib Treatment in Patients With Diabetes and Metastatic Renal Cell CarcinomaQ89257815
Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18Q24319697
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Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell GrowthQ28545791
Valproic Acid Promotes Human Glioma U87 Cells Apoptosis and Inhibits Glycogen Synthase Kinase-3β Through ERK/Akt SignalingQ32186831
Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patientsQ33672932
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Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancerQ35196533
AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage.Q35786083
AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximabQ35793842
No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study.Q35810943
Metformin therapy and prostate cancer risk: a meta-analysis of observational studiesQ36182935
AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal TransitionQ36316820
Metformin inhibits gastric cancer cells metastatic traits through suppression of epithelial-mesenchymal transition in a glucose-independent mannerQ36320084
Association between metformin and the risk of gastric cancer in patients with type 2 diabetes mellitus: a meta-analysis of cohort studiesQ36370966
Influence of metformin intake on the risk of bladder cancer in type 2 diabetes patientsQ36410079
The impact of metformin use on recurrence and cancer-specific survival in clinically localized high-risk renal cell carcinomaQ37342956
Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer CellsQ37579970
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Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived XenograftsQ38376497
Metformin and the risk of renal cell carcinoma: a case-control analysis.Q38409320
Microparticulate and nanoparticulate drug delivery systems for metformin hydrochlorideQ38590960
UCA1 involved in the metformin-regulated bladder cancer cell proliferation and glycolysisQ38699316
Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancerQ38774498
Effect of metformin on the proliferation and apoptosis of the renal cancer cell line 786-O and the underlying mechanismsQ38822039
Combination of metformin and valproic acid synergistically induces cell cycle arrest and apoptosis in clear cell renal cell carcinomaQ38867200
Metformin Use and Kidney Cancer Outcomes in Patients With Diabetes: A Propensity Score Analysis.Q38899340
The relationship between platinum drug resistance and epithelial-mesenchymal transitionQ39061847
Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cellsQ39085692
Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cellsQ39159869
Acquired resistance to sunitinib in human renal cell carcinoma cells is mediated by constitutive activation of signal transduction pathways associated with tumour cell proliferationQ39213121
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Metformin inhibits renal cell carcinoma in vitro and in vivo xenograftQ39523939
Effect of Metformin Use on Survival Outcomes in Patients With Metastatic Renal Cell CarcinomaQ39557946
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.Q39630008
Use of metformin and risk of kidney cancer in patients with type 2 diabetesQ40249088
No reduced risk of overall, colorectal, lung, breast, and prostate cancer with metformin therapy in diabetic patients: database analyses from Germany and the UK.Q40778391
Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein ResponseQ40885419
The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling.Q40900704
The effect of diabetes and metformin on clinical outcomes is negligible in risk-adjusted endometrial cancer cohortsQ41096699
Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta-analysisQ41303279
Cross-communication between histone H3 and H4 acetylation and Akt-mTOR signalling in prostate cancer cellsQ41874831
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.Q42163084
Valproic acid resensitizes cisplatin-resistant ovarian cancer cellsQ42170797
Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathwaysQ43935098
Markers of epithelial-mesenchymal transition in renal cell carcinomaQ44840603
Increased activated Akt expression in renal cell carcinomas and prognosisQ46386017
Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer.Q47129780
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
renal cell carcinomaQ1164529
P304page(s)434
P577publication date2018-04-17
P1433published inBMC CancerQ326300
P1476titleValproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal.
P478volume18

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cites work (P2860)
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Q92612020Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes
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Q64254388Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling
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Q59138314Pleiotropic Effects of Metformin on Cancer
Q90584530Resveratrol inhibits ACHN cells via regulation of histone acetylation
Q92623870Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome
Q90704453Synergistic induction of apoptosis in a cell model of human leukemia K562 by nitroglycerine and valproic acid
Q92714278Targeting ROR1 inhibits epithelial to mesenchymal transition in human lung adenocarcinoma via mTOR signaling pathway
Q64255334The underlying molecular mechanism and potential drugs for treatment in papillary renal cell carcinoma: A study based on TCGA and Cmap datasets

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