Bufalin induces DNA damage response under hypoxic condition in myeloma cells.

scientific article published on 21 February 2018

Bufalin induces DNA damage response under hypoxic condition in myeloma cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2018.8091
P932PMC publication ID5876453
P698PubMed publication ID29616114

P50authorYawara KawanoQ84529928
P2093author name stringEri Fujii
Hiroyuki Hata
Yutaka Okuno
Naoko Wada
Shiho Fujiwara
Shinya Endo
Yuki Inada
Nao Nishimura
Misaki Kakoki
Toshiya Sugimoto
P2860cites workExtracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myelomaQ28077635
Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based researchQ28484427
Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like PropertiesQ34117287
Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: cardiotoxicity due to more than Na, K-ATPase blockingQ34162874
Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathwaysQ34421829
A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in MiceQ36086031
Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistanceQ37005088
Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathwayQ37190269
Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastomaQ37565283
Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatmentQ37702160
Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer TherapyQ37723274
Hypoxia and hypoxia inducible factors in cancer stem cell maintenanceQ37768064
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell NicheQ37777514
Targeting the bone marrow microenvironment in multiple myeloma.Q38289041
Therapeutic targeting of hypoxia and hypoxia-inducible factor 1 alpha in multiple myeloma.Q38305518
Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1α.Q38754838
Hypoxia-Driven Mechanism of Vemurafenib Resistance in MelanomaQ38755819
Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivoQ38756541
Implications of Oxygen Homeostasis for Tumor Biology and Treatment.Q38876568
Microenvironment drug resistance in multiple myeloma: emerging new playersQ38913083
Modulating tumor hypoxia by nanomedicine for effective cancer therapyQ38961080
Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cellsQ39078376
Cardiac glycosides block cancer growth through HIF-1α- and NF-κB-mediated Plk1Q39161209
Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro.Q39192639
Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalanQ39813872
Effect of multidrug resistance 1/P-glycoprotein on the hypoxia-induced multidrug resistance of human laryngeal cancer cellsQ42413385
Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32).Q42813868
Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cellsQ42838383
Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells.Q44671716
Hypoxia-inducible microRNA-488 regulates apoptosis by targeting Bim in osteosarcomaQ53067116
Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockersQ53083871
Purification and characterization of IgE produced by human myeloma cell line, U266Q69497644
Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancerQ83371465
P433issue5
P921main subjecthypoxiaQ105688
P304page(s)6443-6449
P577publication date2018-02-21
P1433published inOncology LettersQ20640514
P1476titleBufalin induces DNA damage response under hypoxic condition in myeloma cells
P478volume15

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cites work (P2860)
Q89715743Bufalin reverses multidrug resistance by regulating stemness through the CD133/nuclear factor-κB/MDR1 pathway in colorectal cancer
Q92587248Regulation and functions of integrin α2 in cell adhesion and disease

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