The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

scientific article published on 29 March 2018

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.2002417
P932PMC publication ID5892915
P698PubMed publication ID29596476

P50authorAlessio TovaglieriQ86532838
Kevin M HaigisQ87900780
Douglas A. LauffenburgerQ59755238
P2093author name stringKatherine R Baldwin
Vijay Yajnik
Jesse Lyons
Jessica J Gierut
David T Breault
Alina Starchenko
Emily J Poulin
Casie Genetti
Phaedra C Ghazi
P2860cites workAltered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)Q72034273
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A novel mTOR inhibitor is efficacious in a murine model of colitisQ39928484
Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease ModelsQ41706706
Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.Q42722489
Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in miceQ43156844
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
Use of sirolimus (rapamycin) to treat refractory Crohn's diseaseQ46417377
A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's diseaseQ46451550
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.Q51771968
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.Q51803667
Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis.Q51825944
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's EpitheliumQ63406947
Guidelines for the management of inflammatory bowel disease in adultsQ22242049
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseQ22251082
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
QIIME allows analysis of high-throughput community sequencing dataQ24616873
The mTOR pathway and integrating immune regulationQ26830354
Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epitheliumQ27318698
Rapalogs and mTOR inhibitors as anti-aging therapeuticsQ28286510
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cellsQ29614268
Genetics and pathogenesis of inflammatory bowel diseaseQ29616350
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Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.Q34118027
Intestinal epithelial cells in inflammatory bowel diseasesQ34136264
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markersQ34280882
Role of Janus kinase 3 in mucosal differentiation and predisposition to colitisQ34371948
mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg ProfileQ36003240
TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.Q36347242
mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in miceQ36570898
T cell transfer model of chronic colitis: concepts, considerations, and tricks of the tradeQ37100252
Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese MiceQ37137264
In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKsQ37657176
Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.Q37666240
In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture.Q37672580
Pharmacological control of autophagy: therapeutic perspectives in inflammatory bowel disease and colorectal cancer.Q38013293
Intestinal epithelial cells: regulators of barrier function and immune homeostasisQ38190874
The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children.Q38252815
Diverse adult stem cells share specific higher-order patterns of gene expression.Q38513522
Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel diseaseQ38542147
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e2002417
P577publication date2018-03-29
P1433published inPLOS BiologyQ1771695
P1476titleThe colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile
P478volume16

Reverse relations

cites work (P2860)
Q93219752Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD
Q90740755Substrate-based kinase activity inference identifies MK2 as driver of colitis
Q92703579mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease

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