Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.

scientific article published on 2 March 2018

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.201706151
P932PMC publication ID5940299
P698PubMed publication ID29500191

P50authorPierre-Emmanuel RautouQ37830020
Holger GerhardtQ38800803
Anne-Clémence VionQ58391518
Adel HammouteneQ59676461
Anna SzymborskaQ82431760
Alexandra Klaus-BergmannQ87942645
Tuyu ZhengQ87942647
Tijana PerovicQ87942650
Marta Bastos OliveiraQ87942653
Miguel O BernabeuQ87942656
P2093author name stringEireen Bartels-Klein
Irene Hollfinger
Silvanus Alt
P2860cites workRandomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor proteinQ22008584
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signalQ24301688
Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and ciliaQ24633410
The cilia-regulated proteasome and its role in the development of ciliopathies and cancerQ26746930
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Endocytic Control of Cellular Signaling at the Primary CiliumQ38882527
Endothelial Mechanosignaling: Does One Sensor Fit All?Q38888511
TGFβ1 - induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner.Q41474810
Decreased blood flow rate disrupts endothelial repair in vivoQ42039182
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition.Q42044394
IFT88 plays a cilia- and PCP-independent role in controlling oriented cell divisions during vertebrate embryonic developmentQ44809853
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signallingQ44839040
Endothelial cilia mediate low flow sensing during zebrafish vascular developmentQ46040457
Efficient, inducible Cre-recombinase activation in vascular endothelium.Q46767104
Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia.Q47073501
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.Q47138895
SRF selectively controls tip cell invasive behavior in angiogenesis.Q50744342
TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia.Q51812403
Intraflagellar transport is essential for endochondral bone formation.Q51999372
Filopodia are dispensable for endothelial tip cell guidance.Q53089715
The fish epidermal keratocyte as a model system for the study of cell locomotionQ72381144
Angiogenic network formation in the developing vertebrate trunkQ73898704
Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective forceQ74582573
Kinesin motors and primary ciliaQ27003194
Dynamic endothelial cell rearrangements drive developmental vessel regressionQ27312264
A Cilia Independent Role of Ift88/Polaris during Cell MigrationQ27313531
Haemodynamics-driven developmental pruning of brain vasculature in zebrafishQ27318761
Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cellsQ27323051
Endothelial cilia are essential for developmental vascular integrity in zebrafishQ27342995
Fiji: an open-source platform for biological-image analysisQ27860912
Stages of embryonic development of the zebrafishQ27860947
Ciliary proteins link basal body polarization to planar cell polarity regulationQ28585995
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1Q28593836
The primary cilium: a signalling centre during vertebrate developmentQ29547197
Basic and therapeutic aspects of angiogenesisQ29615219
A global double-fluorescent Cre reporter mouseQ29616157
Endothelial cell sensing of flow directionQ30410940
The cilia protein IFT88 is required for spindle orientation in mitosisQ30499405
Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac.Q30544920
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.Q33719706
The effects of hemodynamic force on embryonic developmentQ34082971
Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesisQ34521141
Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formationQ34786522
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentialsQ34972793
Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set pointQ35111511
Mechanism and regulation of nucleocytoplasmic trafficking of smadQ35799545
Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flowQ35974231
Primary cilia of human endothelial cells disassemble under laminar shear stressQ36322273
Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodellingQ36703648
High wall shear stress and spatial gradients in vascular pathology: a reviewQ36800232
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescenceQ37080802
Alk1 controls arterial endothelial cell migration in lumenized vesselsQ37120511
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasiaQ37285438
Signaling cross-talk between TGF-beta/BMP and other pathwaysQ37323342
Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow.Q37533531
Endothelial primary cilia inhibit atherosclerosis.Q37623301
The primary cilium at a glanceQ37690035
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P1104number of pages15
P304page(s)1651-1665
P577publication date2018-03-02
P1433published inJournal of Cell BiologyQ1524550
P1476titlePrimary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression
P478volume217

Reverse relations

cites work (P2860)
Q90632367BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development
Q92305240CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation
Q91410919Cellular signalling by primary cilia in development, organ function and disease
Q90666673Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio)
Q92177465Collateral Vessels Have Unique Endothelial and Smooth Muscle Cell Phenotypes
Q98464985Endothelial Cell Dynamics in Vascular Development: Insights From Live-Imaging in Zebrafish
Q83227945Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1
Q92321956Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes
Q104583543Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function
Q64084340Primary Cilium in Cancer Hallmarks
Q98181031Primary cilia are present on endothelial cells of the hyaloid vasculature but are not required for the development of the blood-retinal barrier
Q55430488The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.
Q93069380The role of endothelial cilia in postembryonic vascular development

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