Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone.

scientific article published in February 1968

Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1210/ENDO-82-2-342
P698PubMed publication ID4951281

P2093author name stringLevine L
Tashjian AH Jr
Yasumura Y
Parker ML
Sato GH
P4510describes a project that usesGH1Q54835767
GH3Q54835769
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell lineQ21014462
P304page(s)342-352
P577publication date1968-02-01
P1433published inEndocrinologyQ3054009
P1476titleEstablishment of clonal strains of rat pituitary tumor cells that secrete growth hormone.
P478volume82

Reverse relations

described by source (P1343)
Q54835767GH1
Q93560951GH1-2C1
Q54835769GH3

cites work (P2860)
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Q35313397Direct visualization of receptors for thyrotropin-releasing hormone with a fluorescein-labeled analog
Q47964268Dispersed cell culture of bovine pars intermedia
Q45309454Disruption of the golgi apparatus with brefeldin a does not destabilize the associated detyrosinated microtubule network
Q37575237Do you know the sex of your cells?
Q37692458Dual modulation of K channels by thyrotropin-releasing hormone in clonal pituitary cells
Q72853021Effect of 17β-Estradiol on thyroliberin responsiveness in GH3/B6 rat prolactin cells
Q40335904Effect of gsp oncogene on somatostatin receptor subtype 1 and 2 mRNA levels in GHRH-responsive GH3 cells
Q71723989Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells
Q72498244Effect of thyroliberin on the biosynthesis of poly(A)-mRNA species in GH3 cells. Direct evidences for alterations in their distribution profiles and increased synthesis of the preprolactin mRNA
Q40063197Effect of thyroliberin on the concentration of adenosine 3′:5′-phosphate and on the activity of adenosine 3′:5′-phosphate-dependent protein kinase in prolactin-producing cells in culture
Q71645447Effects of TRH on cell proliferation of rat pituitary cells (GH3)
Q41355211Effects of cortisol, 17?-estradiol and thyroliberin on prolactin and growth hormone production, cell grwoth and cell cycle distribution in cultured rat pituitary tumour cells
Q43484029Effects of vitamin D3 metabolites on production of prolactin and growth hormone in rat pituitary cells
Q41033108Endogenous pacemaker activity of rat tumour somatotrophs
Q36203493Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhbition of cell proliferation
Q41120041Epidermal growth factor protects GH3 cells from adenosine induced growth arrest
Q34501861Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph
Q35011315Establishment and characterization of a strain of human adrenal tumor cells that secrete estrogen
Q36190200Establishment of a clonal strain of hepatoma cells which secrete albumin
Q38690409Establishment of a protocol to extend the lifespan of human hormone-secreting pituitary adenoma cells.
Q33901630Estrogen action in the regulation of cell proliferation, cell survival, and tumorigenesis in the rat anterior pituitary gland
Q37596085Estrogen control of prolactin synthesis in vitro
Q40847961Estrogen mitogenic action. III. is phenol red a "red herring"?
Q73096702Estrogen mitogenic action. ii. negative regulation of the steroid hormone-responsive growth of cell lines derived from human and rodent target tissue tumors and conceptual implications
Q37106608Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs
Q73789382Estrogen-modulated estrogen receptor x Pit-1 protein complex formation and prolactin gene activation require novel protein synthesis
Q71267681Evaluation of growth hormone production from GH1 cells in vitro: effect of culture media and time in culture
Q41660043Evidence for TRH-induced influx of extracellular Ca2+ in pituitary GH4C1 cells
Q69828670Evidence for specific binding of 15 hydroxyeicosatetraenoic acid to pituitary rat cells
Q36272220Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer
Q41369369Evidence that the thyrotropin-releasing hormone receptor and its ligand are recycled dissociated from each other
Q74453801Expression and Regulation of Transforming Growth Factor B1 in Cultured Normal and Neoplastic Rat Pituitary Cells
Q36888549Expression of the Epstein-Barr virus gp350/220 gene in rodent and primate cells
Q35655741Fast-activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: a dynamic clamp study
Q39658856Formation of very large conductance channels by Bacillus cereus Nhe in Vero and GH(4) cells identifies NheA + B as the inherent pore-forming structure.
Q36551161Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain
Q33886598GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene
Q42524081GH3 cell secretion of growth hormone and prolactin increases spontaneously during perifusion
Q37392980GH3 pituitary adenoma cells can reverse thymic aging in rats
Q33932619GH3 tumor pituitary cell cytoskeleton and plasma membrane arrangement are determined by extracellular matrix proteins: implications on motility, proliferation and hormone secretion
Q99594427GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Q41051697Ganglioside composition of GH3 cells: enhancement of fucoganglioside expression by estradiol, epidermal growth factor and insulin
Q36326076Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression
Q41735645Gonadotropes in a novel rat pituitary tumor cell line, RC-4B/C. Establishment and partial characterization of the cell line
Q35959520Gossypol acetate induced apoptosis of pituitary tumor cells by targeting the BCL-2 via the upregulated microRNA miR-15a.
Q39619834Growth hormone. Control of release and characteristics in plasma
Q70275025Hepatocyte insulin binding and action in rats with sommatomammotrophic tumours
Q41110413Hexarelin, a novel GHRP-6 analog, stimulates growth hormone (GH) release in a GH-secreting rat cell line (GH1) insensitive to GH-releasing hormone
Q34481584High-speed fluorescence imaging and intensity profiling of femtosecond-induced calcium transients.
Q89481514Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells
Q37578504Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
Q72432178Hormonal control of tyrosine aminotransferase, prolactin, and growth hormone induction in somatic cell hybrids
Q37930261Hormonal regulation of cytosolic free calcium and its functional consequences: the GH-cell model
Q37000513Hormonal regulation of prolactin storage in a clonal strain of rat pituitary tumor cells
Q39109551Hydrocortisone binding receptor in the rat pituitary GH3 cell line
Q40110353Hydrocortisone increases the number of receptors for thyrotropin-releasing hormone on pituitary cells in culture
Q66947173Hypercalcemia and tumor-prostaglandins: The VX2 carcinoma model in the rabbit
Q36924882Identification of an estrogen-responsive element from the 5'-flanking region of the rat prolactin gene
Q48131578Identification of latent tissue kallikrein, prolactin and growth hormone secretion in GH3 pituitary cells using modified radioimmunoassays
Q43507998Identification of overlapping AP-2/NF-kappa B-responsive elements on the rat cholecystokinin gene promoter
Q36801353Immortalization of Neuroendocrine Cells by Targeted Oncogenesis
Q37693193Immunolocalization of estrogen receptor protein in the mouse blastocyst during normal and delayed implantation
Q42517691In vivo insulin antagonism but evanescent in vitro tissue effect in rats with growth hormone-secreting tumors
Q33637567Increase in T-type calcium current in atrial myocytes from adult rats with growth hormone-secreting tumors
Q41741311Induction of distinct phenotypes in clonal and variant GH4 pituitary cells
Q41291804Induction of prolactin synthesis in rat pituitary tumor cells by 5-bromodeoxyuridine
Q36294619Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor
Q41430179Induction of secretogranin II mRNA by protein synthesis inhibitors in GH4C1 cells
Q42828701Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid
Q41335208Inhibition of Prolactin Secretion and Synthesis by Dopamine, Noradrenaline and Pilocarpine in Cultured Rat Pituitary Tumour Cells
Q37678626Inhibition of growth of a prolactin and growth hormone-secreting pituitary tumor in rats by D-tryptophan-6 analog of luteinizing hormone-releasing hormone
Q44789354Inhibitor of protein synthesis co-isolating with polyribosomal RNA
Q41561741Inhibitors of the arachidonic acid metabolism attenuate the thyroliberin (TRH) stimulated prolactin production without modifying the production of inositolphosphates in GH4C1 pituitary cells
Q34610080Insulin suppresses growth hormone secretion by rat pituitary cells
Q36837368Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.
Q72903600Interaction of calcium and cyclic nucleotides in thyroliberin-stimulated prolactin release
Q48425110Interaction of dihydropyridine Ca2+ agonist Bay K 8644 with normal and transformed pituitary cells
Q39923169Intrinsic tryptophan fluorescence of membranes of GH3 pituitary cells: Quenching by thyrotropin-releasing hormone
Q48258989Is bursting more effective than spiking in evoking pituitary hormone secretion? A spatiotemporal simulation study of calcium and granule dynamics
Q34321908Isolation and characterization of s-myc, a member of the rat myc gene family
Q34663825Isolation of cells that retain differentiated functions in vitro: properties of clonally isolated type II alveolar pneymonocytes
Q48181440Large and small conductance calcium-activated potassium channels in the GH3 anterior pituitary cell line
Q48410392Lethal effects of the combination of hyperthermia and bromocriptine or a somatostatin analogue on normal pituitary cells and pituitary tumour cells
Q70462634Long-term monolayer culture of human anterior pituitary cells: functional validation of a method
Q41980821Mechanism of spontaneous intracellular calcium fluctuations in single GH4C1 rat pituitary cells
Q42484840Medium flow rate modulates autocrine-paracrine feedback of GH and PRL release by perifused GH3 cells
Q33774986Membrane oestrogen receptors on rat pituitary tumour cells: immuno-identification and responses to oestradiol and xenoestrogens
Q54466633Membrane patches and whole-cell membranes: a comparison of electrical properties in rat clonal pituitary (GH3) cells
Q66974506Metabolism of [3H]-testosterone and [1,2-3H]-dihydrotestosterone by prolactin secreting rat pituitary tumour cells in culture
Q35458348Methylation of either cytosine in the recognition sequence CGCG inhibits ThaI cleavage of DNA.
Q40733151Mitogen-activated protein kinase mediates epidermal growth factor-induced morphogenesis in pituitary GH3 cells
Q36379188Models of electrical activity: calibration and prediction testing on the same cell
Q35585769Modulation by 1,25-dihydroxycholecalciferol of the acute change in cytosolic free calcium induced by thyrotropin-releasing hormone in GH4C1 pituitary cells
Q44523890Modulation of somatostatin receptors by thyrotropin-releasing hormone in a clonal pituitary cell strain
Q37835689Molecular Mechanisms of Steroid Hormone Action
Q41744875Monoclonal antibodies to ROS 17/2.8 cells recognize antigens, some of which are restricted to osteoblasts and chondrocytes
Q41683100Multiple calcium currents in a thyroid C-cell line: biophysical properties and pharmacology
Q54735680Multiple differentiated functions in an unusual clonal strain of hepatoma cells.
Q42449892Muscarinic acetylcholine receptor activation causes inhibition of cyclic AMP accumulation, prolactin and growth hormone secretion in GH3 rat anterior pituitary tumour cells
Q34336282NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice
Q41581124Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes
Q40365067Nitric oxide induces [Ca2+]i oscillations in pituitary GH3 cells: involvement of IDR and ERG K+ currents
Q40883773Novel action of pituitary adenylate cyclase-activating polypeptide. Stimulation of extracellular acidification in rat pituitary GH4C1 cells
Q39985041Nucleotidase activity in regenerating liver and in clonal strains of hepatoma and pituitary cells in culture
Q40841038Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone
Q72856751On the role of extracellular Ca2+ for prolactin release and adenosine 3′:5′-monophosphate formation induced by thyroliberin in cultured rat pituitary cells
Q48110020Pharmacological characterization of two calcium currents in GH3 cells
Q78083135Pit-1 mediates cell-specific and cAMP-induced transcription of the tilapia GH gene
Q40887287Pituitary Sex Steroid Receptors: Localization and Function
Q36860297Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation.
Q88647810Pituitary somatolactotropes evade an oncogenic response to Ras
Q24631604Pituitary somatostatin receptor signaling
Q41695739Platelet-activating factor affects cytosolic free calcium concentration and prolactin secretion in GH4C1 rat pituitary cells
Q41289736Production of activin A in human intestinal epithelial cell line.
Q36193203Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells. Differential effects of hydrocortisone and tissue extracts
Q36971184Prolactin-deficient variants of GH3 rat pituitary tumor cells: linked expression of prolactin and another hormonally responsive protein in GH3 cells
Q40182889Prolactin-producing cells in culture: control of hormone biosynthesis and release
Q72917099Purification and characterization of plasma membrane fractions from cultured pituitary cells
Q40222596Quenching of intrinsic tryptophan fluorescence in membranes of rat pituitary cells
Q39087246RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor
Q44710254Rat Growth Hormone Expression in Cell Hybrids
Q69954588Rat pituitary tumor cells in serum-free culture. I. Selection of thyroid hormone-responsive and autonomous cells
Q42505327Rat pituitary tumor cells in serum-free culture. II. Serum factor and thyroid hormone requirements for estrogen-responsive growth
Q48847258Redox modulation of calcium entry and release of intracellular calcium by thimerosal in GH4C1 pituitary cells
Q44325378Regulation of Growth Hormone Messenger RNA
Q35057730Regulation of aryl hydrocarbon receptor interacting protein (AIP) protein expression by MiR-34a in sporadic somatotropinomas
Q42452824Regulation of excitation-secretion coupling by thyrotropin-releasing hormone (TRH): Evidence for TRH receptor-ion channel coupling in cultured pituitary cells
Q40009108Regulation of gene expression in somatic cell hybrids: a review
Q40159864Regulation of pituitary receptors for thyrotropin-releasing hormone by thyroid hormones
Q70197494Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides
Q72929546Relationship between stimulated prolactin release from gh cells and cyclic amp degradation and formation
Q72397796Relationship between thyroid and glucocorticoid hormone receptor occupancy, growth hormone gene transcription, and mRNA accumulation
Q34115359Relationships between amplitudes and kinetics of rapid cytosolic free calcium fluctuations in GH4C1 rat pituitary cells: roles for diffusion and calcium-induced calcium release
Q40651707Relative Responses of an X-ray-resistant Hybrid Cell-line and Its Parent Line to X-irradiation, Ultraviolet Light, Actinomycin D and Cordycepin
Q39997615Release and synthesis of prolactin by rat pituitary cell strains are regulated independently by thyrotropin-releasing hormone
Q41977729Replacement of serum by hormones permits growth of cells in a defined medium
Q34220094Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage
Q39605167Role of calcium in the thyrotropin-releasing hormone-stimulated release of prolactin from pituitary cells in culture
Q55689941Role of pituitary adenylate cyclase-activating polypeptide in modulating hypothalamic-pituitary system.
Q41101409Sapecin B, a novel fly toxin, blocks macroscopic K+ currents in the GH3 rat pituitary cell line
Q70730686Selection procedures for mammalian cells in monolayer culture
Q67275195Separation of VX-2 rabbit carcinoma-derived cells capable of releasing collagenase
Q71031813Short-term effect of estrogen on release of prolactin by pituitary cells in culture
Q33745743Single-cell qPCR on dispersed primary pituitary cells -an optimized protocol
Q48192034Sodium and potassium currents involved in action potential propagation in normal bovine lactotrophs
Q40157682Solubilization of pituitary receptors for thyrotropin-releasing hormone
Q55489837Somatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production
Q35875782Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter
Q36223871Spatial and temporal colocalization of the Golgi apparatus and microtubules rich in detyrosinated tubulin
Q48915293Specific antisense RNA inhibition of growth hormone production in differentiated rat pituitary tumour cells
Q41067741Sphingosine inhibits voltage-operated calcium channels in GH4C1 cells
Q44781233Spontaneous calcium action potentials in a clonal pituitary cell line and their relationship to prolactin secretion
Q41337601Stereological and biochemical analysis of prolactin and growth hormone secreting rat pituitary cells in culture. Stereology combined with non-parametrical statistics
Q40005684Stimulation of prolactin synthesis and of adenosine 3':5'-cyclic phosphate formation by prostaglandins and thyroliberin in cultured rat pituitary cells
Q48892721Studies of calcium channels in rat clonal pituitary cells with patch electrode voltage clamp
Q54692748Studies of single calcium channel currents in rat clonal pituitary cells
Q35103632Subunits of Human Chorionic Gonadotropin: Unbalanced Synthesis and Secretion by Clonal Cell Strains Derived from a Bronchogenic Carcinoma
Q31159859Synthesis and characterization of a high-affinity photoactivatable analogue of thyrotropin-releasing hormone
Q74453944TGF-B and Estrogen Regulate P27(Kip1) and Cyclin D(1) in Normal and Neoplastic Rat Pituitary Cells
Q48562419TRH-induced membrane hyperpolarization in rat clonal anterior pituitary cells
Q34653589The bacterial peptide pheromone plantaricin A permeabilizes cancerous, but not normal, rat pituitary cells and differentiates between the outer and inner membrane leaflet
Q53687849The balance of PI3K and ERK signaling is dysregulated in prolactinoma and modulated by dopamine.
Q48962071The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner
Q72745082The calcium agonist Bay K 8644 stimulates secretion from a pituitary cell line
Q84586297The effect of water soluble cyanotoxin(s) produced by two species of Anabaena on the release of acetylcholine from the peripheral cholinergic nervous system of the rat airway
Q72743109The effects of 5-azacytidine on the expression of the rat growth hormone gene. Methylation modulates but does not control growth hormone gene activity
Q44452884The effects of hydrogen peroxide on brain and brain tumors
Q42452347The lipoxygenase inhibitor nafazatrom inhibits stimulated prolactin secretion in cultured rat lactotrophs (GH4C1 cells)
Q36469830The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development
Q28287153The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles
Q40224585Thyroid hormone action in pituitary cells. Differences in the regulation of thyrotropin-releasing hormone receptors and growth hormone synthesis
Q30273647Thyroid hormone and apotransferrin regulation of growth hormone secretion by GH1 rat pituitary tumor cells in iron restricted serum-free defined medium
Q37045223Thyroid hormone regulation of rat pituitary tumor cell growth: A new role for apotransferrin as an autocrine thyromedin
Q38781461Thyroid hormone transcriptional regulatory region of the growth hormone gene
Q67919165Thyroid hormone-dependent pituitary tumor cell growth in serum-free chemically defined culture. A new regulatory role for apotransferrin
Q41558779Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action
Q71569643Thyrotropin releasing hormone rapidly enhances [32P]orthophosphate incorporation into phosphatidic acid in cloned GH3 cells
Q40104358Thyrotropin releasing hormone. A review of the mechanisms of acute stimulation of pituitary hormone release
Q40118211Thyrotropin-releasing hormone modulation of uridine uptake in rat pituitary cells. Characterization of the responses
Q37571505Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells
Q69005729Thyrotropin-releasing hormone stimulates a calcium-activated potassium current in a rat anterior pituitary cell line
Q37000322Thyrotropin-releasing hormone stimulation of prolactin release from clonal rat pituitary cells: evidence for action independent of extracellular calcium
Q42823863Thyrotropin-releasing hormone-diphtheria toxin-related polypeptide conjugates. Potential role of the hydrophobic domain in toxin entry
Q37782677Tissue Culture in Endocrine Research: Perspectives, Pitfalls, and Potentials
Q36064355Tissue specific trans-acting factor interaction with proximal rat prolactin gene promoter sequences.
Q35971744Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging.
Q36923624Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements
Q41338265Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor
Q36814887Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific protein
Q47973047Transfer of cytoplasmic and nuclear proteins between cells in culture
Q68347239Transplantation of human breast epithelia to mammary-gland-free fat-pads of athymic nude mice: Influence of mammotrophic hormones on growth of breast epithelia
Q54409816Two distinct calcium-activated potassium currents in a rat anterior pituitary cell line.
Q39944062Ultrastructural study of the testicular interstitial cells and the prostate involution in rats bearing a transplantable prolactin and growth hormone-producing tumor
Q34707303Unexpected resistance to x-irradiation in a strain of hybrid mammalian cells
Q42445552Unresponsiveness of GH cells to cyclo(histidyl-proline), a metabolite of thyrotropin releasing hormone
Q40015267Up-regulation of high voltage-activated Ca(2+) channels in GC somatotropes after long-term exposure to ghrelin and growth hormone releasing peptide-6.
Q48732454Up-regulation of the estrogen receptor by triiodothyronine in rat pituitary cell lines
Q37433058Upregulation of voltage-gated calcium channel cav1.3 in bovine somatotropes treated with ghrelin
Q41250478Variations in prolactin and growth hormone production during cellular growth in clonal strains of rat pituitary cells
Q41826933Vasoactive-intestinal-polypeptide-stimulated adenosine 3′,5′-cyclic monophosphate accumulation in GH3 pituitary tumour cells. Reversal of desensitization by forskolin
Q71264108Viral perturbation of endocrine function: disordered cell function leads to disturbed homeostasis and disease
Q36247272Visualization of the interaction of a regulatory protein with RNA in vivo
Q40972814Visualization of unoccupied and occupied gonadotropin-releasing hormone receptors in living cells
Q70197442Voltage-dependent calcium channels in pituitary cells in culture. II. Participation in thyrotropin-releasing hormone action on prolactin release
Q40515204d(TG)n.d(CA)n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription

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