| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/SIM.4780131308 |
| P698 | PubMed publication ID | 7973215 |
| P2093 | author name string | DeMets DL | |
| Lan KK | |||
| P433 | issue | 13-14 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1341-52; discussion 1353-6 | |
| P577 | publication date | 1994-07-01 | |
| P1433 | published in | Statistics in Medicine | Q7604438 |
| P1476 | title | Interim analysis: the alpha spending function approach. | |
| P478 | volume | 13 |
| Q47292306 | A Randomized Trial of Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection |
| Q39314704 | A Tutorial on Hunting Statistical Significance by Chasing N. |
| Q35771013 | A comparison of two worlds: How does Bayes hold up to the status quo for the analysis of clinical trials? |
| Q34133971 | A protocol for active surveillance of acute myocardial infarction in association with the use of a new antidiabetic pharmaceutical agent |
| Q54980235 | A randomized controlled phase II trial of vaccination with lysate-loaded, mature dendritic cells integrated into standard radiochemotherapy of newly diagnosed glioblastoma (GlioVax): study protocol for a randomized controlled trial. |
| Q38374699 | A randomized controlled trial of ganaxolone in posttraumatic stress disorder |
| Q43733221 | A simple algorithm for designing group sequential clinical trials |
| Q35206844 | Adaptive clinical trial designs in oncology |
| Q27335043 | An automated internet behavioral weight-loss program by physician referral: a randomized controlled trial |
| Q35018547 | An experienced physiotherapist prescribing and administering corticosteroid and local anaesthetic injections to the shoulder in an Australian orthopaedic service, a non-inferiority randomised controlled trial and economic analysis: study protocol fo |
| Q36772361 | Antenatal Betamethasone for Women at Risk for Late Preterm Delivery |
| Q37296987 | Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis |
| Q64286989 | Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework |
| Q36734048 | Bayesian Group Sequential Clinical Trial Design using Total Toxicity Burden and Progression-Free Survival |
| Q92640187 | Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial |
| Q34586436 | Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial |
| Q33584895 | Bortezomib in late antibody-mediated kidney transplant rejection (BORTEJECT Study): study protocol for a randomized controlled trial |
| Q35557396 | Bridging clinical investigators and statisticians: writing the statistical methodology for a research proposal |
| Q56373211 | Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma |
| Q92724560 | Clinical Trial Portfolios: A Critical Oversight in Human Research Ethics, Drug Regulation, and Policy |
| Q92889750 | Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles |
| Q36203718 | Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial |
| Q35062156 | Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial |
| Q73816032 | Computations for group sequential boundaries using the Lan-DeMets spending function method |
| Q48127884 | Conclusive meta-analyses on antenatal magnesium may be inconclusive! Are we underestimating the risk of random error? |
| Q38301224 | Constraint-induced movement therapy: trial sequential analysis applied to Cochrane collaboration systematic review results |
| Q42221013 | Continuous sequential boundaries for vaccine safety surveillance |
| Q38825084 | Continuously updated network meta-analysis and statistical monitoring for timely decision-making |
| Q36073872 | Corticosteroids Versus Pentoxifylline for Severe Alcoholic Hepatitis: A Sequential Analysis of Randomized Controlled Trials |
| Q55114463 | Daptomycin versus placebo as an adjunct to beta-lactam therapy in the treatment of Staphylococcus aureus bacteremia: study protocol for a randomized controlled trial. |
| Q54983289 | Defining information fractions in group sequential clinical trials with multiple endpoints. |
| Q30356518 | Design and Rationale of the Best Endovascular Versus Best Surgical Therapy for Patients With Critical Limb Ischemia (BEST-CLI) Trial. |
| Q30276131 | Design, rationale, and baseline characteristics of the randomized double-blind phase II clinical trial of ibudilast in progressive multiple sclerosis |
| Q92128877 | Detailed statistical analysis plan for the SafeBoosC III trial: a multinational randomised clinical trial assessing treatment guided by cerebral oxygenation monitoring versus treatment as usual in extremely preterm infants |
| Q38796117 | Different materials for direct pulp capping: systematic review and meta-analysis and trial sequential analysis |
| Q96299485 | Do we need to adjust for interim analyses in a Bayesian adaptive trial design? |
| Q53537312 | Early stopping of clinical trials in lupus and other uncommon rheumatologic diseases. |
| Q38372557 | Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial |
| Q64113667 | Effect of Chemotherapy With Docetaxel With Androgen Suppression and Radiotherapy for Localized High-Risk Prostate Cancer: The Randomized Phase III NRG Oncology RTOG 0521 Trial |
| Q38371830 | Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial |
| Q47232913 | Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial |
| Q28250518 | Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial |
| Q28219856 | Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial |
| Q96304104 | Epigastric port retrieval of the gallbladder following laparoscopic cholecystectomy is associated with the reduced risk of port site infection and port site incisional hernia: An updated meta-analysis of randomized controlled trials |
| Q45934500 | Etirinotecan pegol (NKTR-102) versus treatment of physician's choice in women with advanced breast cancer previously treated with an anthracycline, a taxane, and capecitabine (BEACON): a randomised, open-label, multicentre, phase 3 trial. |
| Q37436377 | Evaluation of efficacy and efficiency of a pragmatic intervention by a social worker to support informal caregivers of elderly patients (The ICE Study): study protocol for a randomized controlled trial |
| Q36697448 | Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial |
| Q38926363 | False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review |
| Q39691725 | Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses |
| Q31085620 | Futility approaches to interim monitoring by data monitoring committees |
| Q40046733 | Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): a phase 3, randomised controlled trial |
| Q52609357 | Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial. |
| Q36304127 | Increasing efficiency of preclinical research by group sequential designs |
| Q30886528 | Independent data monitoring committees: an update and overview |
| Q42410759 | Interim analyses in diagnostic versus treatment studies: differences and similarities |
| Q39834471 | Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals |
| Q40468855 | Interpreting trial sequential analysis. |
| Q35849907 | Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic l |
| Q80056708 | Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia: a randomised controlled trial |
| Q55285098 | Long-Term Efficacy of Maintenance Therapy for Multiple Myeloma: A Quantitative Synthesis of 22 Randomized Controlled Trials. |
| Q50632243 | Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome. |
| Q83477164 | Low-dose rectal diclofenac for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized controlled trial |
| Q58910970 | Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials |
| Q30669416 | Modification of the sample size and the schedule of interim analyses in survival trials based on data inspections |
| Q42656778 | Monitoring of large randomised clinical trials: a new approach with Bayesian methods |
| Q34417512 | Multiplicity in randomised trials II: subgroup and interim analyses |
| Q35852007 | New developments in medical clinical trials. |
| Q48013252 | Noninvasive continuous positive airway pressure in elderly cardiogenic pulmonary edema patients |
| Q35650082 | Periodontal treatment for preventing adverse pregnancy outcomes: a meta- and trial sequential analysis |
| Q42928480 | Phase III Trial of Carboplatin Plus Paclitaxel With or Without Gemcitabine in First-Line Treatment of Epithelial Ovarian Cancer |
| Q34625239 | Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial |
| Q35825194 | Planning and monitoring of placebo-controlled survival trials: comparison of the triangular test with usual interim analyses methods |
| Q37693976 | Preventing recurrence of endometriosis by means of long-acting progestogen therapy (PRE-EMPT): report of an internal pilot, multi-arm, randomised controlled trial incorporating flexible entry design and adaption of design based on feasibility of rec |
| Q24634688 | Prevention of HIV-1 infection with early antiretroviral therapy |
| Q89540270 | Progress in the treatment of gastric cancer in Japan over the last 50 years |
| Q47938054 | Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial |
| Q34261229 | Prostate-cancer mortality at 11 years of follow-up |
| Q38986405 | Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer |
| Q33375619 | Randomised phase III trial of carboplatin plus etoposide vs split doses of cisplatin plus etoposide in elderly or poor-risk patients with extensive disease small-cell lung cancer: JCOG 9702 |
| Q84490942 | Randomized controlled single-center trial comparing pancreatogastrostomy versus pancreaticojejunostomy after partial pancreatoduodenectomy |
| Q37099985 | Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: results from a prospectively designed analysis o |
| Q36491239 | Randomized trial of adjuvant thalidomide versus observation in patients with completely resected high-risk renal cell carcinoma |
| Q33741119 | Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study. |
| Q90128076 | Rationale and design of the granulocyte-macrophage colony stimulating factor in peripheral arterial disease (GPAD-3) study |
| Q39174741 | Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure |
| Q30887421 | Regulatory perspectives on data safety monitoring boards: protecting the integrity of data |
| Q30990772 | Repeated looks at accumulating data: to correct or not to correct? |
| Q35750976 | Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents |
| Q30731720 | Role of the Data and Safety Monitoring Committee (DSMC). |
| Q51741687 | Safety and Effectiveness of Direct Oral Anticoagulants Versus Vitamin K Antagonists: Pilot Implementation of a Near-Real-Time Monitoring Program in Italy. |
| Q34041688 | Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. |
| Q30821732 | Selective laser trabeculoplasty versus argon laser trabeculoplasty: results from a 1-year randomised clinical trial |
| Q25257362 | Sequential boundaries approach in clinical trials with unequal allocation ratios. |
| Q45771351 | Sequential meta-analysis: an efficient decision-making tool |
| Q39446987 | Single-incision surgery trocar-site hernia: an updated systematic review meta-analysis with trial sequential analysis by the Minimally Invasive Surgery Synthesis of Interventions Outcomes Network (MISSION). |
| Q50093637 | Small-scale analysis of suspected cancer clusters based on cancer registry data |
| Q36309775 | Statistical considerations for the HPTN 052 Study to evaluate the effectiveness of early versus delayed antiretroviral strategies to prevent the sexual transmission of HIV-1 in serodiscordant couples |
| Q34752410 | Surgical versus nonsurgical therapy for lumbar spinal stenosis |
| Q35786928 | TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial |
| Q36763617 | The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial |
| Q33226962 | The Complications of Age-Related Macular Degeneration Prevention Trial (CAPT): rationale, design and methodology |
| Q33809318 | The agonising negative trend in monitoring of clinical trials |
| Q24288961 | The thresholds for statistical and clinical significance - a five-step procedure for evaluation of intervention effects in randomised clinical trials |
| Q34421870 | The utility of Bayesian predictive probabilities for interim monitoring of clinical trials |
| Q34009196 | Therapeutic studies |
| Q34071751 | Third-wave cognitive therapy versus mentalisation-based treatment for major depressive disorder: a randomised clinical trial |
| Q37668195 | Thromboelastometry versus standard coagulation tests versus restrictive protocol to guide blood transfusion prior to central venous catheterization in cirrhosis: study protocol for a randomized controlled trial |
| Q90130842 | Treatment of advanced AIDS-associated Kaposi sarcoma in resource-limited settings: a three-arm, open-label, randomised, non-inferiority trial |
| Q64236406 | Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial |
| Q39360969 | Trials stopped early: too good to be true? |
| Q36800592 | Understanding and preventing wrong-patient electronic orders: a randomized controlled trial |
| Q34026728 | Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial |
| Q39079500 | Weekly docetaxel versus CMF as adjuvant chemotherapy for older women with early breast cancer: final results of the randomized phase III ELDA trial. |
| Q38616823 | When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment |
| Q38852150 | When is a meta-analysis conclusive? A guide to Trial Sequential Analysis with an example of remote ischemic preconditioning for renoprotection in patients undergoing cardiac surgery |
| Q94608381 | [Early interruption of clinical trials: too good to be true?] |
| Q77626525 | [Principles of tests of hypotheses in statistics: alpha, beta and P] |
| Q53528273 | [Trial sequential analysis : Sample size calculation for reliable meta-analyses]. |
Search more.