Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6.

scientific article published on 2 July 2015

Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/AJMG.A.37214
P932PMC publication ID6027752
P698PubMed publication ID26139588
P5875ResearchGate publication ID279727291

P2093author name stringIgor Chesnokov
Maxim Balasov
Katarina Akhmetova
P2860cites workFunctional analysis of mutant and wild-type Drosophila origin recognition complexQ24555148
Mutations in the pre-replication complex cause Meier-Gorlin syndromeQ24629357
An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexesQ24676407
The cell biology of planar cell polarityQ26828482
Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIBQ27667555
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
Architecture of the yeast origin recognition complex bound to origins of DNA replicationQ27940033
latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutantQ28117657
Assembly of the human origin recognition complexQ28185696
The origin recognition complex: from simple origins to complex functionsQ28210087
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexQ28241786
Multiple functions of the origin recognition complexQ28284492
Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome.Q30446039
A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activityQ30968824
Orc mutants arrest in metaphase with abnormally condensed chromosomes.Q33941569
Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.Q34143699
GAL4 system in Drosophila: a fly geneticist's Swiss army knifeQ34151737
A structural role for ATP in the formation and stability of the human origin recognition complexQ34596596
A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscissionQ34712449
Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loadingQ34714083
Functional insight into the role of Orc6 in septin complex filament formation in DrosophilaQ34786026
Assembly of functionally active Drosophila origin recognition complex from recombinant proteinsQ35197011
Crystal structure of the eukaryotic origin recognition complexQ35202495
Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosisQ35969087
The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2Q36106897
The many faces of the origin recognition complexQ36805011
The origin recognition complex is dispensable for endoreplication in DrosophilaQ36858551
Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex.Q37035156
The origin recognition complex protein familyQ37213779
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formationQ37217690
Functional analysis of an Orc6 mutant in DrosophilaQ37250029
Principles of planar polarity in animal developmentQ37869265
Planar cell polarity signaling: coordination of cellular orientation across tissuesQ38052130
Polarized trafficking provides spatial cues for planar cell polarization within a tissueQ38407237
Sequence-independent DNA binding and replication initiation by the human origin recognition complexQ39896073
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndromeQ41935686
Role of the Orc6 protein in origin recognition complex-dependent DNA binding and replication in Drosophila melanogasterQ42092579
Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?Q42560029
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndromeQ45170252
A Drosophila homolog of the yeast origin recognition complexQ46909082
Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathwayQ47070449
Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutantsQ47071017
[Genetic control of mitosis. Adaptive modifications of v158 mutation expression]Q52584290
Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.Q53612703
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectMeier-Gorlin syndromeQ19587381
P304page(s)2533-2540
P577publication date2015-07-02
P1433published inAmerican Journal of Medical GeneticsQ4744254
P1476titleDrosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6.
P478volume167A

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cites work (P2860)
Q45314103Assembly of the ORC complex at the origin of replication
Q39392236Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development
Q50286263Formation of ORC(1-6) complex
Q41918306Rapid DNA Synthesis During Early Drosophila Embryogenesis Is Sensitive to Maternal Humpty Dumpty Protein Function
Q40970716Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Q38985016The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery

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