Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers.

scientific article published on 30 September 2014

Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers. is …
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scholarly articleQ13442814

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P356DOI10.3109/00498254.2014.967824
P698PubMed publication ID25268386

P50authorDoo-Yeoun ChoQ60311745
P2093author name stringEuichaul Oh
Bom-Taeck Kim
Sukhyang Lee
Soo Kyung Bae
Jung Bae Park
Joeng Kee Lee
Soo Hyeon Bae
Yang-Weon Kim
P2860cites workSarpogrelate treatment reduces restenosis after coronary stentingQ28195521
The 5-HT2 receptor antagonist sarpogrelate reduces urinary and plasma levels of thromboxane A2 and urinary albumin excretion in non-insulin-dependent diabetes mellitus patientsQ28368134
Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activityQ30872988
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In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail arteryQ34313846
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The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerationsQ39422300
Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteersQ42622887
Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomesQ42708698
Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humansQ43555133
Long-term treatment with metoprolol after myocardial infarction: effect on 3 year mortality and morbidityQ44208902
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Pharmacokinetics of a new once-daily controlled-release sarpogrelate hydrochloride compared with immediate-release formulation and the effect of foodQ44615221
Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in KoreansQ46052063
Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteersQ46332841
Inhibition of 5-hydroxytryptamine receptor prevents occlusive thrombus formation on neointima of the rabbit femoral arteryQ46892256
Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers.Q50990638
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)256-263
P577publication date2014-09-30
P1433published inXenobioticaQ1360678
P1476titleEffect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers
P478volume45