UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer.

scientific article published on 8 November 2010

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CNCR.25531
P698PubMed publication ID21351083
P5875ResearchGate publication ID50197007

P50authorUrszula OleksiewiczQ59555936
Angeliki MalliriQ61274025
John K. FieldQ42754256
Anastasia FiliaQ56435798
George XinarianosQ56444885
P2093author name stringTriantafillos Liloglou
John R Gosney
Alexandros Daskalos
George Nikolaidis
P2860cites workThe human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumorsQ22010018
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domainQ24303631
UHRF1 plays a role in maintaining DNA methylation in mammalian cellsQ24336152
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growthQ24534791
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNAQ24645346
ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cellsQ24651299
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencingQ24652350
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1Q27651995
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanismQ27651997
DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsQ28212826
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancerQ28240062
The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell linesQ74421009
The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycleQ28260808
Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferationQ28588925
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNAQ28589108
Epigenetics in cancerQ29547853
Epigenetics in cancerQ29617139
The DNA methyltransferases of mammalsQ29617317
Methylation-induced repression--belts, braces, and chromatinQ29617487
Linking DNA methylation and histone modification: patterns and paradigmsQ29617801
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassemblyQ30494105
DNA methylation, methyltransferases, and cancerQ30993657
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic valueQ33251855
Rethinking how DNA methylation patterns are maintainedQ33763852
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis.Q33927698
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cellsQ34166536
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumorsQ34573834
Epigenetic gene silencing in cancer: the DNA hypermethylomeQ34646556
Establishment and maintenance of DNA methylation patterns in mammals.Q36434829
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.Q36667464
Proteins that bind methylated DNA and human cancer: reading the wrong wordsQ36740636
The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?Q36894164
Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factorsQ37036306
p16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasiaQ37245583
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.Q37348708
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elementsQ39695383
UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancerQ39770055
DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysisQ39847607
TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assaysQ39850044
Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.Q40050705
Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathwayQ40427781
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cellsQ40559173
Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencingQ41834670
Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features.Q53559080
Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer.Q53591404
DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma.Q53622156
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer.Q54569187
Promoter Methylation and Silencing of the Retinoic Acid Receptor- Gene in Lung CarcinomasQ57890923
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1027-1037
P577publication date2010-11-08
P1433published inCancerQ326041
P1476titleUHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer
P478volume117

Reverse relations

cites work (P2860)
Q36506865A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice
Q41133927Accumulation of genomic alterations in 2p16, 9q33.1 and 19p13 in lung tumours of asbestos-exposed patients
Q37279405Amplicon Resequencing Identified Parental Mosaicism for Approximately 10% of "de novo" SCN1A Mutations in Children with Dravet Syndrome
Q35848254An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer
Q35662659Analysis of UHRF1 expression in human ovarian cancer tissues and its regulation in cancer cell growth
Q40751381Analysis of the UHRF1 expression in serum and tissue for gastric cancer detection
Q39449331Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.
Q28394629Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population
Q35165791Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway.
Q37718344CDDO-Me reveals USP7 as a novel target in ovarian cancer cells
Q38756270Clinicopathological analysis of UHRF1 expression in medulloblastoma tissues and its regulation on tumor cell proliferation
Q57210488Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions
Q93065274DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications
Q42585685Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts
Q89879844Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
Q39252224Diagnostic and prognostic value of plasma and tissue ubiquitin-like, containing PHD and RING finger domains 1 in breast cancer patients
Q34989248Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties
Q37705867Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma
Q60912066Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
Q36346904Epigenetic mechanisms in anti-cancer actions of bioactive food components--the implications in cancer prevention
Q38313414Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma
Q42877755L-methionase: a therapeutic enzyme to treat malignancies
Q55009932LINE-1 hypomethylation is inversely correlated with UHRF1 overexpression in gastric cancer.
Q55633259Long noncoding RNA UPAT promoted cell proliferation via increasing UHRF1 expression in non-small cell lung cancer.
Q54977612Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL.
Q26742136Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease
Q37588387Molecular gene signature and prognosis of non-small cell lung cancer
Q54244821Overexpression of UHRF1 is significantly associated with poor prognosis in laryngeal squamous cell carcinoma.
Q24315922PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression
Q36386895Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer
Q36189555RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation
Q28073257Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
Q36781882TPL2 kinase is a suppressor of lung carcinogenesis
Q47130735Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy
Q55129550Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development.
Q37937460The Roles of the Methyl-CpG Binding Proteins in Cancer
Q39304639The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.
Q24297944The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein
Q60044999The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism
Q55445741Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells.
Q64063558UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells
Q37105752UHRF1 gene silencing inhibits cell proliferation and promotes cell apoptosis in human cervical squamous cell carcinoma CaSki cells
Q36587931UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy
Q54330859UHRF1 promotes cell growth and metastasis through repression of p16(ink⁴a) in colorectal cancer.
Q36211327UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation
Q91676720UHRF1 promotes renal cell carcinoma progression through epigenetic regulation of TXNIP
Q37628934UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma
Q36536562UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis
Q64913033UHRF1 suppression promotes cell differentiation and reduces inflammatory reaction in anaplastic thyroid cancer.
Q55333913WDR79 mediates the proliferation of non-small cell lung cancer cells by regulating the stability of UHRF1.
Q37651410Zebrafish Discoveries in Cancer Epigenetics.

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