How can we recognize "disease modification" effects?

scientific article published in April 2009

How can we recognize "disease modification" effects? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12603-009-0036-7
P698PubMed publication ID19300873

P2093author name stringE R Siemers
P2860cites workGene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
The role of biomarkers in clinical trials for Alzheimer diseaseQ31032781
Imaging-based measures of disease progression in clinical trials of disease-modifying drugs for Alzheimer diseaseQ33186215
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.Q34417339
Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's diseaseQ35114490
Alzheimer disease: mechanistic understanding predicts novel therapiesQ35750804
Frequent amyloid deposition without significant cognitive impairment among the elderlyQ37085957
Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer diseaseQ37192883
Optimal design of clinical trials for drugs designed to slow the course of Alzheimer's diseaseQ37549247
The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 casesQ39104464
Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteersQ46555308
Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretaseQ46843030
Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer diseaseQ46966608
Two-year follow-up of amyloid deposition in patients with Alzheimer's diseaseQ48467767
Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.Q48893777
Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium".Q49075598
Longitudinal stability of CSF tau levels in Alzheimer patients.Q51981435
Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.Q51983988
Longitudinal stability of CSF biomarkers in Alzheimer's disease.Q53286684
Are surrogate markers adequate to assess cardiovascular disease drugs?Q78175808
P433issue4
P304page(s)341-343
P577publication date2009-04-01
P1433published inThe Journal of Nutrition, Health and AgingQ23051112
P1476titleHow can we recognize "disease modification" effects?
P478volume13

Reverse relations

cites work (P2860)
Q37730012Biochemical markers in Alzheimer's disease clinical trials
Q37769104Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
Q39432592Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside
Q34098866Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Q87388529Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men
Q26784569Fluid Biomarkers in Clinical Trials of Alzheimer's Disease Therapeutics
Q36186513Fluid biomarkers in Alzheimer disease
Q53300553Imaging and biomarkers will be used for detection and monitoring progression of early Alzheimer's disease.
Q38113683Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
Q26866006New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs
Q41683709The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson's disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain
Q53300550Use of biomarkers in Alzheimer's trials.
Q37814497Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease
Q35533115Using biomarkers to improve detection of Alzheimer's disease.

Search more.