The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac.

scientific article published on 28 September 2011

The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/00498254.2011.607196
P698PubMed publication ID21955249
P5875ResearchGate publication ID51677971

P50authorIan WilsonQ38644500
Alex J GavinQ58132289
P2093author name stringElin Karlsson
Huw B Jones
Sunil Sarda
Kathryn Pickup
Timothy Schulz-Utermoehl
Chris Page
Kerry Ratcliffe
P2860cites workCytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomasQ28343187
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolismQ28510829
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2Q28591646
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathwaysQ28679171
Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactionsQ34717194
Acyl glucuronide reactivity in perspective: biological consequencesQ35103665
Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicityQ35566803
Acyl glucuronides: the good, the bad and the ugly.Q37787116
NSAID acyl glucuronides and enteropathyQ37852045
Biotransformation of diclofenac sodium (Voltaren) in animals and in man. I. Isolation and identification of principal metabolitesQ39710218
Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytesQ42558143
Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.Q43240503
Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.Q53404409
Conditional Gene Knockout Using Cre RecombinaseQ56114286
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectDiclofenacQ244408
P304page(s)195-205
P577publication date2011-09-28
P1433published inXenobioticaQ1360678
P1476titleThe hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac
P478volume42

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cites work (P2860)
Q41010784Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice
Q51301442Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.
Q42702145Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice
Q48813784The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse

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