Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs.

scientific article published on 31 May 2015

Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00125-015-3637-1
P698PubMed publication ID26026653

P50authorMartin Bødtker MortensenQ55856237
Jacob Fog BentzonQ57070223
Christina ChristoffersenQ58929492
Rozh H Al-MashhadiQ59206013
P2093author name stringErling Falk
Torben Larsen
Martin M Bjørklund
P2860cites workIntensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 DiabetesQ22250887
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitusQ24202505
Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic dietQ28377461
Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in ratsQ28564538
Is glycaemia or insulin dose the stronger risk factor for coronary artery disease in type 1 diabetes?Q33833060
Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesionsQ33916802
Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery diseaseQ34150587
Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trialQ34660831
Predictors of incident albuminuria in the Framingham Offspring cohortQ35404652
Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in miceQ35858148
Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes MellitusQ36176985
Type 1 diabetes and coronary artery diseaseQ36634829
Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) studyQ37054992
Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI studyQ37106389
Type 1 diabetes, hyperglycaemia, and the heartQ37172723
The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) StudyQ37239766
Increased atherosclerosis in streptozotocin-induced diabetic miceQ37353969
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
Atherosclerotic lesions in mouse and man: is it the same disease?Q37777606
Why does diabetes increase atherosclerosis? I don't know!Q39951404
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproductsQ41009444
Diabetes-induced accelerated atherosclerosis in swineQ43651836
Studies on the energy metabolism of pig red cells. I. The limiting role of membrane permeability in glycolysisQ43841864
Glycemia (or, in women, estimated glucose disposal rate) predict lower extremity arterial disease events in type 1 diabetesQ43879632
Lipoprotein lipase deficiency and CETP in streptozotocin-treated apoB-expressing miceQ44007466
Increased atherosclerosis in diabetic dyslipidemic swine: protection by atorvastatin involves decreased VLDL triglycerides but minimal effects on the lipoprotein profileQ44168286
Reduction of cardiac functional reserve and elevation of aortic stiffness in hyperlipidemic Yucatan minipigs with systemic and coronary atherosclerosisQ44344010
Effects of streptozotocin-induced diabetes in apolipoprotein AI deficient miceQ44716932
Risk factors for coronary heart disease in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications StudyQ44745070
Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutantQ44937777
Association between glycosylated hemoglobin level and cardiovascular and all-cause mortality in type 1 diabetesQ44994691
Effect of streptozotocin-induced hyperglycemia on lipid profiles, formation of advanced glycation endproducts in lesions, and extent of atherosclerosis in LDL receptor-deficient miceQ45120387
Overexpression of hyaluronan in the tunica media promotes the development of atherosclerosisQ45261400
Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effectsQ46601696
Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetesQ46696587
Development of atherosclerosis in the diabetic BALB/c mice. Prevention with Vitamin E administrationQ46700742
The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitusQ46783978
The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient miceQ46940719
Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.Q51555624
Intracoronary ultrasound examinations reveal significantly more advanced coronary atherosclerosis in people with type 1 diabetes than in age- and sex-matched non-diabetic controlsQ57740227
Glycemic Control and Excess Mortality in Type 1 DiabetesQ59587753
Intestinal and Hepatic Cholesterogenesis in Hypercholesterolemic Dyslipidemia of Experimental Diabetes in DogsQ67791450
Contributions of Absorbed Dietary Cholesterol and Cholesterol Synthesized in Small Intestine to Hypercholesterolemia in Diabetic RatsQ68434926
Reduced atherogenesis in cholesterol-fed diabetic rabbits. Giant lipoproteins do not enter the arterial wallQ68446303
Hormonal regulation of low-density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells. Insulin increases LDL receptor activity and diminishes its suppression by exogenous LDLQ69827315
Effect of intensive diabetes management on macrovascular events and risk factors in the Diabetes Control and Complications TrialQ72198055
Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice. Effects on lipoproteins and atherosclerosisQ73251589
Coronary calcium in adults with type 1 diabetes: a stronger correlate of clinical coronary artery disease in men than in womenQ74256386
Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetesQ85067293
P433issue8
P921main subjecthypercholesterolemiaQ762713
atherosclerosisQ12252367
P304page(s)1926-1936
P577publication date2015-05-31
P1433published inDiabetologiaQ5270140
P1476titleDiabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs.
P478volume58

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cites work (P2860)
Q37171845A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification
Q49893263Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.
Q51245649Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome.
Q49952246Animal models of obesity and diabetes mellitus
Q89669823Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes
Q37083092Does Elevated Glucose Promote Atherosclerosis? Pros and Cons
Q50107614Genetically engineered pigs as models for human disease
Q36086591Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals
Q55355643Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE-/- mice.
Q38594603Large animal models of atherosclerosis--new tools for persistent problems in cardiovascular medicine
Q36738466Models for preclinical studies in aging-related disorders: One is not for all.
Q51556455Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.
Q64951302Quantitative applications in positron emission tomography achieved through signal modelling.
Q92771839Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study
Q42367561The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol
Q39298787The emerging role of microdialysis in diabetic patients undergoing amputation for limb ischemia
Q64267632Tissue volume and activity mapping using total intensity projection of PET/CT images

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