A tyrosine-specific protein kinase inhibitor, alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells.

scientific article published in June 1990

A tyrosine-specific protein kinase inhibitor, alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1349-7006.1990.TB02622.X
P932PMC publication ID6504068
P698PubMed publication ID2144851
P5875ResearchGate publication ID21010886

P2093author name stringK Watanabe
T Shiraishi
M K Owada
T Kakunaga
Y Fuse
M Tatsuka
P2860cites workTwo human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinaseQ24294982
Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene productQ24611377
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformationQ28609965
High resolution two-dimensional electrophoresis of basic as well as acidic proteinsQ29618832
Cellular oncogenes and retrovirusesQ34256815
Detection of phosphotyrosine-containing 34,000-dalton protein in the framework of cells transformed with Rous sarcoma virusQ35349038
Fodrin: axonally transported polypeptides associated with the internal periphery of many cellsQ36205287
Some Lymphoid Cell Lines Transformed by Abelson Murine Leukemia Virus Lack a Major 36,000-Dalton Tyrosine Protein Kinase SubstrateQ36935761
Nerve growth factor receptors on human melanoma cells in cultureQ37581798
Redistribution of fodrin (a component of the cortical cytoplasm) accompanying capping of cell surface moleculesQ37600709
Tyrosyl protein kinases in normal rat liver: identification and partial characterizationQ37610196
Tyrosine protein kinasesQ40078714
Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins.Q40210749
Transformation by oncogenes encoding protein kinases induces the metastatic phenotypeQ42806558
Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylationQ42818549
Synthesis, turnover, and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblastsQ43671036
A rat mutant cell clone showing temperature-dependent transformed phenotypes with functional expression of the src gene productQ43911580
Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivoQ44708292
An endogenous substrate for the insulin receptor-associated tyrosine kinaseQ44930039
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virusQ45804878
Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosineQ45805762
Epidermal growth factor-dependent phosphorylation of lipocortinQ46389228
Growth factors: Mechanism of action and relation to oncogenesQ53552812
High resolution two-dimensional electrophoresis of basic as well as acidic proteinsQ58492650
Specific inhibitors of tyrosine-specific protein kinase. I. Synthesis and inhibitory activities of .ALPHA.-cyanocinnamamidesQ68484946
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cellsQ68934470
Isolation and characterization of three forms of 36-kDa Ca2+-dependent actin- and phospholipid-binding proteins from human placenta membraneQ69198364
Specific inhibitors of tyrosine-specific protein kinases: properties of 4-hydroxycinnamamide derivatives in vitroQ69586015
Purification and characterization of a protein tyrosine kinase from bovine spleenQ69752866
Specific inhibitors of tyrosine-specific protein kinase, synthetic 4-hydroxycinnamamide derivativesQ69806579
Hyperproduction and gene amplification of the epidermal growth factor receptor in squamous cell carcinomasQ70101263
Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissuesQ70305998
Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylationQ72402371
P433issue6-7
P921main subjectphosphorylationQ242736
P1104number of pages8
P304page(s)645-652
P577publication date1990-06-01
P1433published inJapanese Journal of Cancer ResearchQ26842384
P1476titleA tyrosine-specific protein kinase inhibitor, alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells.
P478volume81

Reverse relations

cites work (P2860)
Q37320501Imaging of EGFR and EGFR tyrosine kinase overexpression in tumors by nuclear medicine modalities.
Q31143648Mass spectrometric characterization of a series of adenosylated peptides acting as bisubstrate analogs of protein kinases
Q37115205Protein kinase inhibitors: probes for the functions of protein phosphorylation
Q41765479Protein tyrosine kinases regulate agonist-stimulated prostacyclin release but not von Willebrand factor secretion from human umbilical vein endothelial cells
Q68026900Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein
Q33832624Tyrosine kinase inhibitors in preclinical development
Q42161394Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents

Search more.