DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function.

scientific article published on 28 April 2018

DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS19051315
P932PMC publication ID5983821
P698PubMed publication ID29710796

P2093author name stringDi Cui
Xiangru Xu
P2860cites workDNA methylation age of human tissues and cell typesQ21183994
Cloning, expression and chromosome locations of the human DNMT3 gene familyQ22010469
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
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Orphan CpG islands identify numerous conserved promoters in the mammalian genomeQ28109656
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityQ28131773
DNA methyltransferase Dnmt1 associates with histone deacetylase activityQ28141500
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Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing.Q51519751
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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.Q51956004
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DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.Q53503415
Hutchinson-Gilford progeria syndrome: review of the phenotype.Q55042199
Stimulation effect of Dnmt3L on the DNA methylation activity of Dnmt3a2Q80198565
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndromeQ82660672
Cortical DNA methylation maintains remote memoryQ42285452
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiationQ42291322
Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation.Q42523444
UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.Q42824871
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylationQ45862749
Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments.Q47408579
Dnmt3a2: a hub for enhancing cognitive functionsQ47616756
Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic StatesQ47620033
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Active and passive demethylation of male and female pronuclear DNA in the mammalian zygoteQ47981749
Epigenetic regulation of Dnmt3a and Arc gene expression after electroconvulsive stimulation in the rat.Q48078778
Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in miceQ48149199
Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI.Q48192075
Spatial working memory in humans as revealed by PET.Q48266348
The effects of hippocampal lesions upon spatial and non-spatial tests of working memoryQ48378274
The epigenotype. 1942.Q48429495
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.Q48587952
The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agentsQ48693317
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.Q49078217
DNA mismatch repair and DNA methylation in adult brain neurons.Q49158568
Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.Q49163873
No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairmentQ50217511
Replication timing-related and gene body-specific methylation of active human genes.Q39626565
The Janus face of DNA methylation in agingQ39914567
DNA methylation changes in plasticity genes accompany the formation and maintenance of memory.Q40222482
Loss of axosomatic synapses in the dentate gyrus of aged ratsQ41547831
Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory ProcessesQ28201636
Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structuresQ28256467
DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interactionQ28258202
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memoryQ28300376
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferasesQ28507226
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1Q28575665
Covalent modification of DNA regulates memory formationQ28576256
Functions of DNA methylation: islands, start sites, gene bodies and beyondQ29547260
Perceptions of epigeneticsQ29547310
DNA methylation: roles in mammalian developmentQ29616796
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genomeQ29616819
DNA methylation landscapes: provocative insights from epigenomicsQ29617144
Cancer epigenetics comes of ageQ29617275
The DNA methyltransferases of mammalsQ29617317
Global epigenomic reconfiguration during mammalian brain developmentQ29617800
Chromatin modification and epigenetic reprogramming in mammalian developmentQ29617802
Epigenetic modifications and human diseaseQ29619753
DNA methylation regulates associative reward learningQ30547330
DNA methylation on N(6)-adenine in mammalian embryonic stem cellsQ30796539
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neuronsQ33299459
Multi-tissue DNA methylation age predictor in mouseQ33556578
Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse heartsQ33557670
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genesQ33742114
Epigenetic aging clocks in mice and menQ33795803
Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series).Q33806018
Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylationQ33913612
Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation.Q33945996
Cytosine methylation and CpG, TpG (CpA) and TpA frequenciesQ33978876
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilitiesQ34032603
DNA Methylation on N6-Adenine in C. elegansQ34043905
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.Q34103901
Genomic 5-methyldeoxycytidine decreases with age.Q34185566
Epigenetic changes in Alzheimer's disease: decrements in DNA methylationQ34233161
Working memory: looking back and looking forwardQ34267089
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other lociQ34433829
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.Q34579673
Selective role for DNMT3a in learning and memoryQ34602652
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemiaQ34627568
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ CellsQ34670376
Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formationQ35036368
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.Q35169651
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cellsQ35554558
DNA methylation signatures in development and aging of the human prefrontal cortexQ35748368
Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiationQ35941031
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DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort StudyQ36339504
Adult neurogenesis and functional plasticity in neuronal circuitsQ36404122
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.Q36687168
Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancerQ36848353
DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe.Q36873208
DNA methylation impacts on learning and memory in agingQ36938828
Epigenetic regulation in mammalian preimplantation embryo developmentQ37242454
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.Q37638856
S-adenosylmethionine levels regulate the schwann cell DNA methylome.Q37651384
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos.Q37729754
Alzheimer's disease genetics: current knowledge and future challengesQ37801363
Region-specific genetic alterations in the aging hippocampus: implications for cognitive agingQ37806962
DNA methylation and its basic functionQ38025275
Cellular changes in the enteric nervous system during ageingQ38093934
Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patternsQ38256826
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.Q38296215
Neuronal activity modifies the DNA methylation landscape in the adult brainQ38594616
TREM2 variants: new keys to decipher Alzheimer disease pathogenesisQ38748724
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.Q38852379
Dnmt1, Dnmt3a and Dnmt3b cooperate in photoreceptor and outer plexiform layer development in the mammalian retina.Q39171810
Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegenerationQ39230518
Elucidating the Role of TREM2 in Alzheimer's DiseaseQ39252469
Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?Q39312657
Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell lineQ39457542
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
DNA methylationQ874745
enzymeQ8047
nervous systemQ9404
cognitive dysfunctionQ57859955
P577publication date2018-04-28
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleDNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function.
P478volume19

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cites work (P2860)
Q90396185A microchip electrophoretic assay for DNA methyltransferase activity based on methylation-sensitive endonuclease DpnⅡ
Q90641372An Evaluation of DNA Methyltransferase 1 (DNMT1) Single Nucleotide Polymorphisms and Chemotherapy-Associated Cognitive Impairment: A Prospective, Longitudinal Study
Q90403695Conditional Dnmt3b deletion in hippocampal dCA1 impairs recognition memory
Q90632433DNA Methylation in Neurodegenerative and Cerebrovascular Disorders
Q98466592DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons
Q91717468DNA hypermethylation in disease: mechanisms and clinical relevance
Q90092780DNA methylation is involved in the pathogenesis of osteoarthritis by regulating CtBP expression and CtBP-mediated signaling
Q64057149Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
Q91715584Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model
Q61816301Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification

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