Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site.

scientific article published on 6 June 2007

Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M702192200
P698PubMed publication ID17553804

P50authorJean-Luc PellequerQ42212458
P2093author name stringXiao Xu
Subramanian Yegneswaran
John H Griffin
Andrew J Gale
P2860cites workComplete cDNA and derived amino acid sequence of human factor VQ24605169
Proposed structural models of the prothrombinase (FXa-FVa) complexQ28293819
The dynamics of thrombin formationQ28610129
Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein CQ28631087
Peptide Bond Cleavages and Loss of Functional Activity during Inactivation of Factor Va and Factor VaR506Q by Activated Protein CQ34305158
The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor functionQ34829515
Proteases in blood clottingQ35015141
Identification of functionally important residues in proteins using comparative models.Q35698603
Mutating factor VIII: lessons from structure to functionQ35967952
Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.Q36280112
Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein CQ38269759
The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX.Q38362540
Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombinQ40502059
Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virusQ40506219
Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa.Q42533684
Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complexQ44045917
Defining the factor Xa-binding site on factor Va by site-directed glycosylationQ44183079
Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the processQ44258994
Amino Acids Glu323, Tyr324, Glu330, and Val331 of Factor Va Heavy Chain Are Essential for Expression of Cofactor ActivityQ44435259
Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.Q44798012
Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complexQ45032492
Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variantsQ45858392
Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complexQ46097485
Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis.Q52485676
A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.Q53595426
Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.Q54102151
Soluble Phospholipids Enhance Factor Xa-Catalyzed Prothrombin Activation in Solution†Q57977129
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectdrotrecogin alfaQ412888
P1104number of pages8
P304page(s)21848-21855
P577publication date2007-06-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site.
P478volume282

Reverse relations

cites work (P2860)
Q36122255A bipartite autoinhibitory region within the B-domain suppresses function in factor V
Q36915890A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex.
Q37415619Amino acid region 1000-1008 of factor V is a dynamic regulator for the emergence of procoagulant activity
Q92129559Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding
Q34127509Computational reconstruction of multidomain proteins using atomic force microscopy data
Q30354087Conformational dynamics of individual antibodies using computational docking and AFM.
Q44242838DockAFM: benchmarking protein structures by docking under AFM topographs
Q46806167Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.
Q52874413Identification and functional characterization of a novel F5 mutation (Ala512Val, FVB onn ) associated with activated protein C resistance.
Q40422254Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis
Q33996371Regulation of the protein C anticoagulant and antiinflammatory pathways
Q37233988Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides
Q36863328Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding.
Q89765217TFPIα interacts with FVa and FXa to inhibit prothrombinase during the initiation of coagulation