Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy.

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Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00395-015-0485-6
P698PubMed publication ID25851234

P50authorManolis MavroidisQ63974769
Constantinos H DavosQ64515124
P2093author name stringJ Peter van Tintelen
Aimilia Varela
Yassemi Capetanaki
Axel Vater
Christian Maasch
Ioanna Kostavasili
Stelios Psarras
Michalis Katsimpoulas
Nikolaos C Athanasiadis
P2860cites workEffects of complement activation in the isolated heart. Role of the terminal complement componentsQ43804974
Arrhythmogenic cardiomyopathy: a biventricular disease in search of a cureQ43865288
Changes and regulation of the C5a receptor on neutrophils during septic shock in humansQ44402512
Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularizationQ47233244
Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injuryQ47580544
The sepsis seesaw: seeking a heart salveQ47856950
Myocardial inflammation and non-ischaemic heart failure: is there a role for C-reactive protein?Q48675155
The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration.Q50481050
New insights into the molecular basis of desmoplakin- and desmin-related cardiomyopathies.Q50708085
Histologic findings in patients with clinical and instrumental diagnosis of sporadic arrhythmogenic right ventricular dysplasia.Q51662829
Null mutation in the desmin gene gives rise to a cardiomyopathy.Q52526996
Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.Q52567974
Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria.Q55638651
Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES geneQ57200485
The C5a chemoattractant receptor mediates mucosal defence to infectionQ24318486
Mutations with pathogenic potential in proteins located in or at the composite junctions of the intercalated disk connecting mammalian cardiomyocytes: a reference thesaurus for arrhythmogenic cardiomyopathies and for Naxos and Carvajal diseasesQ27024101
The novel desmin mutant p.A120D impairs filament formation, prevents intercalated disk localization, and causes sudden cardiac deathQ28114840
Genotype-phenotype assessment in autosomal recessive arrhythmogenic right ventricular cardiomyopathy (Naxos disease) caused by a deletion in plakoglobinQ33147005
Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study.Q33175413
Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion modelQ33704554
The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic functionQ33883081
De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathyQ34137061
Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasiaQ34166873
Disruption of muscle architecture and myocardial degeneration in mice lacking desminQ34395897
Validation of noninvasive measurements of cardiac output in mice using echocardiography.Q34796110
Desmoglein 2 mutant mice develop cardiac fibrosis and dilation.Q35017328
Complement dependency of cardiomyocyte release of mediators during sepsisQ35043866
Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy.Q35467456
Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathyQ35788752
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunctionQ36227873
Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function.Q36293799
Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure.Q36677507
Function and regulation of the complement system in cardiovascular diseasesQ36814088
Muscle intermediate filaments and their links to membranes and membranous organellesQ36825339
How can we cure a heart "in flame"? A translational view on inflammation in heart failureQ37004826
Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathyQ37292752
A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsisQ37393792
Complement-mediated ischemia-reperfusion injury: lessons learned from animal and clinical studiesQ37498110
Animal models of arrhythmogenic cardiomyopathyQ37628322
Desmin-related myopathyQ37780788
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunityQ37830940
Arrhythmogenic cardiomyopathy: transgenic animal models provide novel insights into disease pathobiologyQ37889542
Cardiac desmosomal (dys)function and myocyte viabilityQ39890038
A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization.Q43184436
P433issue3
P304page(s)27
P577publication date2015-04-08
P1433published inBasic Research in CardiologyQ2453360
P1476titleComplement system modulation as a target for treatment of arrhythmogenic cardiomyopathy
P478volume110

Reverse relations

cites work (P2860)
Q42377369Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.
Q39948025Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene
Q28115277Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect
Q60046136Identification of Crucial Genes and Pathways in Human Arrhythmogenic Right Ventricular Cardiomyopathy by Coexpression Analysis
Q38599642Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant
Q37702217Influence of aging on the activity of mice Sca-1+CD31- cardiac stem cells
Q90356556Intermediate filaments in cardiomyopathy
Q39094595Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins
Q33757711Metformin protects against infection-induced myocardial dysfunction
Q36100438Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.
Q64084317Three in a Box: Understanding Cardiomyocyte, Fibroblast, and Innate Immune Cell Interactions to Orchestrate Cardiac Repair Processes
Q36322072Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling
Q33641786Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.
Q47340446Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin

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