Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.

scientific article published on 5 December 2006

Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M606003200
P8608Fatcat IDrelease_tjdiycjklzdhljuithepqstxu4
P698PubMed publication ID17148446

P2093author name stringRichard L Eckert
Sivaprakasam Balasubramanian
P2860cites workInhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcuminQ24798384
The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiationQ28202057
Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alphaQ28206453
Regulation of involucrin gene expressionQ28266509
The distal regulatory region of the human involucrin promoter is required for expression in epidermisQ28287929
Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activityQ28301991
Mitochondrial control of cell deathQ29617739
Life-or-death decisions by the Bcl-2 protein family.Q31879227
A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formationQ34206534
Function and regulation of AP-1 subunits in skin physiology and pathologyQ34279351
Curcumin: getting back to the roots.Q34563815
Apoptosomes: engines for caspase activationQ35021215
The cell cycle: a review of regulation, deregulation and therapeutic targets in cancerQ35157537
The Bcl-2 family: roles in cell survival and oncogenesis.Q35591695
Opposing action of curcumin and green tea polyphenol in human keratinocytesQ36365203
Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin.Q38334881
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.Q38353590
Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcuminQ38502784
Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.Q40319484
Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targetsQ40401027
Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.Q40452646
Gonadotropin-releasing hormone receptor-targeted gene therapy of gynecologic cancers.Q40457750
Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systemsQ40500676
Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosomeQ40510305
Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesisQ40517197
Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway.Q40602802
Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytesQ40717246
Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathwayQ40839619
Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetateinduced tumor promotionQ41289806
Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cellsQ42453027
Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermisQ42492741
Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transitionQ42820912
Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytesQ43792260
Curcumin downregulates cell survival mechanisms in human prostate cancer cell linesQ43830972
Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activationQ43968074
New and known symmetrical curcumin derivatives inhibit the formation of Fos-Jun-DNA complexQ44053477
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylationQ44250309
Human wee1 kinase is directly transactivated by and increased in association with c-Fos/AP-1: rheumatoid synovial cells overexpressing these genes go into aberrant mitosisQ44611169
Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein functionQ44814586
Human epidermal keratinocytes undergo (-)-epigallocatechin-3-gallate-dependent differentiation but not apoptosisQ45271621
A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosisQ46459242
Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunctionQ46974612
Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis.Q53448278
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcurcuminQ312266
keratinocyteQ1473931
P304page(s)6707-6715
P577publication date2006-12-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleCurcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.
P478volume282

Reverse relations

cites work (P2860)
Q394655251-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation
Q64095593A Review of Curcumin and Its Derivatives as Anticancer Agents
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Q37366494Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells
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Q35939370Curcumin inhibits interferon-γ signaling in colonic epithelial cells
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Q38836327Curcumisome nanovesicles generated by self-assembly of curcumin amphiphiles toward cancer theranostics
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Q37034014Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications
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Q28729714Retracted: Suppression of AP1 Transcription Factor Function in Keratinocyte Suppresses Differentiation
Q30398272Small molecule inhibitors targeting activator protein 1 (AP-1).
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