β-Glucuronidase Catalyzed Hydrolysis of Benzo[ a ]pyrene-3-Glucuronide and Binding to DNA (scientific article published on January 20, 1978)

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene

Q35015352

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides

Q35029342

Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen

Q35984711

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells

Q35986055

Comparison of the metabolism of benzo[a]pyrene and binding to DNA caused by rat liver nuclei and microsomes

Q39081155

Activation of the O-glucuronide of the carcinogen N-hydroxy-N-2-fluorenylacetamide by enzymatic deacetylation in vitro: Formation of fluorenylamine-tRNA adducts

Q39092693

Enzymatic formation and properties of a conjugate of sulfate with 3-hydroxybenzo(a)pyrene

Q39147354

The intermediary metabolism of 3:4-benzpyrene: the biosynthesis and identification of the X1 and X2 metabolites

Q39982995

The intermediary metabolism of 3:4-benzpyrene

Q39983905

Assay and properties of glutathione-S-benzo(a)pyrene-4,5-oxide transferase

Q40350999

Metabolic degradation of 3,4-benzopyrene in the cultures of normal and neoplastic fibroblasts

Q41395900

AN ENZYME CATALYSING THE CONJUGATION OF EPOXIDES WITH GLUTATHIONE

Q42965406

On the nature of the product which results when 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene is metabolised in vitro and bound to DNA.

Q43574049

The role of 9-hydroxybenzo(a)pyrene in the microsome mediated binding of benzo(a)pyrene to DNA

Q43756955

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

Q44117425

Federation Proceedings

Q45106928

Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct

Q45264122

Environmental carcinogens and large bowel cancer

Q46772099

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

Q47986339

Isolation and characterization of an active DNA-binding metabolite of benzo(a)pyrene from hamster liver microsomal incubation systems

Q53795573

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Q59062693

Fluorescence spectral evidence that benzo(a)pyrene‐DNA products in mouse skin arise from diol‐epoxides

Q67321328

Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid

Q67754558

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo

Q67799938

Benzo(a)pyren-3-yl hydrogen sulphate, a major ethyl acetate-extractable metabolite of benzo(a)pyrene in human, hamster and rat lung cultures

Q67851308

Metabolism and binding to cellular macromolecules of a series of hydrocarbons by mouse embryo cells in culture

Q71313679

Synthesis of the O-glucuronide of N-2-fluorenylhydroxylamine. Reaction with nucleic acids and with guanosine 5'-monophosphate

Q71443355

P433

issue

4326

P407

language of work or name

English

Q1860

P304

page(s)

307-309

P577

publication date

1978-01-01

1978-01-20

P1433

published in

Science

Q192864

P1476

title

beta-Glucuronidase catalyzed hydrolysis of benzo(a)pyrene-3-glucuronide and binding to DNA

β-Glucuronidase Catalyzed Hydrolysis of Benzo[ a ]pyrene-3-Glucuronide and Binding to DNA

P478

volume

199

Reverse relations

cites work (P2860)

Q40705950	Cancer mortality in chronic typhoid and paratyphoid carriers
Q37444361	Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk
Q40622103	Carcinoma of the gallbladder--is it a sequel of typhoid?
Q35298288	Detoxification of polycyclic aromatic hydrocarbons by fungi
Q37513237	Doenjang, a fermented Korean soybean paste, inhibits lipopolysaccharide production of gut microbiota in mice.
Q42267827	Effect of selected induction of microsomal and nuclear aryl hydrocarbon monooxygenase and epoxide hydrolase as well as cytoplasmic glutathione S-epoxide transferase on the covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo
Q66918895	Effects of Various in Vitro - inhibitors of Benzo(a)pyrene Metabolism in Isolated Rat Lung Perfusion
Q28541212	Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells
Q41384130	Enhanced lipid peroxidation and lysosomal enzyme activity in the lungs of rats with prolonged pulmonary deposition of crocidolite asbestos.
Q41666592	Food as a source of polycyclic aromatic carcinogens.
Q37968331	Gallbladder cancer: can newer insights improve the outcome?
Q28319217	Glucuronidation of Lipophilic Substrates: Preparation of 3-Benzo[a]pyrenyl-β-D-glucopyranosiduronic Acid in Multimilligram Quantities by Microsomal UDP-Glucuronyl Transferase
Q34196447	Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons
Q50202061	In vitro intestinal microflora-mediated metabolism of biliary metabolites from 1-nitropyrene-treated rats
Q41678950	Lysosomal enzymes in pure pancreatic juice from normal healthy volunteers and chronic alcoholics
Q66970913	Major differences in the extent of conjugation with glucuronic acid and sulphate in human peripheral lung
Q28740769	Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line
Q50211262	Mutagenicity and in vivo disposition of biliary metabolites of benzo(a)pyrene
Q50181672	Mutagenicity of benzo(a)pyrenyl-1-sulfate in the Ames test
Q41820943	Mutagenicity testing on Chinese hamster V79 cells treated in the in vitro liver perfusion system. Comparative investigation of different in vitro metabolising systems with dimethylnitrosamine and benzo[a]pyrene
Q39753419	Pathways involved in the metabolism and activation of polycyclic hydrocarbons
Q39696187	Photodynamic cytotoxicity of mammalian cells exposed to sunlight-simulating near ultraviolet light in the presence of the carcinogen 7,12-dimethylbenz(a)anthracene
Q41491427	Properties of Two Molecular Forms of beta-Glucuronidase from the Mollusc Littorina littorea L
Q68320744	Qualitative and quantitative differences in the induction and inhibition of hepatica benzo[a]pyrene metabolism in the rat and hamster
Q37368782	Roles of UDP-glucuronosyltransferases in chemical carcinogenesis
Q72934639	Roles of Udp-Glucuronosyltransferase in the Inactivation of Benzo(a)Pyrene
Q66920827	Separation of water-soluble metabolites of benzo[a]pyrene formed by cultured human colon
Q27732608	Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs
Q35115430	Systematic review with meta-analysis: the relationship between chronic Salmonella typhi carrier status and gall-bladder cancer
Q41578231	The discrepancy between in vivo and in vitro experiments with polycyclic aromatic hydrocarbon(PAH) carcinogens: a hypothetical explanation
Q39839095	The effect of diet on the mammalian gut flora and its metabolic activities
Q41557034	The role of beta-glucuronidase in drug disposition and drug targeting in humans
Q39798829	TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase
Q39643751	UDP-glucuronosyl transferase and the conjugation of benzo(a)pyrene metabolites to DNA

P819	ADS bibcode	1978Sci...199..307K
P356	DOI	10.1126/SCIENCE.619459
P8608	Fatcat ID	release_yhkj3tihqvfp7ipdvys4wnycqi
P953	full work available at URL	https://syndication.highwire.org/content/doi/10.1126/science.619459
P698	PubMed publication ID	619459