Loss of p16INK4A expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected synovial sarcomas.

scientific article published on 5 August 2005

Loss of p16INK4A expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected synovial sarcomas. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00428-005-0024-1
P698PubMed publication ID16082560

P2093author name stringElaine Kay
Mary Leader
Robert Cummins
Muna Sabah
P2860cites workp15INK4B is a potential effector of TGF-beta-induced cell cycle arrestQ24319021
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancersQ24606341
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancersQ28251857
A cell cycle regulator potentially involved in genesis of many tumor typesQ28251933
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53Q28266637
Cancer cell cyclesQ29547756
Molecular mechanisms underlying human synovial sarcoma developmentQ33927348
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Q34078091
Mutations of cell cycle regulators. Biological and clinical implications for human neoplasiaQ35798342
Alterations of cell cycle regulators in localized synovial sarcoma: A multifactorial study with prognostic implicationsQ35809860
Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological featuresQ38463098
Loss of heterozygosity on chromosome 9q21 (p16 gene) uncommon in soft-tissue sarcomasQ41130523
Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survivalQ43910252
Loss of heterozygosity of chromosome 9p and loss of p16INK4A expression are associated with malignant gastrointestinal stromal tumorsQ47385250
Loss of p16 (INK4A) expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected malignant peripheral nerve sheath tumors.Q53632256
Altered expression of G1 regulatory proteins in human soft tissue sarcomas.Q53671241
Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p.Q54678584
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancersQ55480673
Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading systemQ71259989
Frequency of homozygous deletion at p16/CDKN2 in primary human tumoursQ71721193
Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcomaQ71975366
Rates of p16 (MTS1) mutations in primary tumors with 9p lossQ72041274
Allelic loss at the D9S171 locus on chromosome 9p13 is associated with progression of papillary renal cell carcinomaQ73504522
Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcomaQ73552676
Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomasQ73622335
Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNAQ74025313
Infrequent mutation of the p16/MTS1 gene and overexpression of cyclin-dependent kinase 4 in human primary soft-tissue sarcomaQ74490616
Gene alterations at the CDKN2A (p16/MTS1) locus in soft tissue tumorsQ74777769
P433issue5
P921main subjectheterozygosityQ124059385
P304page(s)842-848
P577publication date2005-08-05
P1433published inVirchows ArchivQ19059548
P1476titleLoss of p16INK4A expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected synovial sarcomas.
P478volume447

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cites work (P2860)
Q60727809Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays
Q28250373Laser capture microdissection technology
Q60673340Laser-capture microdissection
Q52724204Performance of the UroVysion® FISH assay for the diagnosis of malignant effusions using two cutoff strategies.
Q37150456Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.